Results 101 to 110 of about 246,994 (340)
PIK3CAH1047R DNA in colorectal cancer (CRC) cell‐derived exosomes can be delivered into recipient fibroblasts, where it is transcribed and translated, leading to the activation of fibroblasts into cancer‐associated fibroblasts, which secrete elevated levels of IL6. The simultaneous detection and targeting of PIK3CAH1047R mutation and IL6 may serve as a
Rui Wang+6 more
wiley +1 more source
Compared with the non‐risk G allele of rs9606, the risk T allele of rs9606 decreases the binding affinity of NUDT21 for LYRM4, triggering 3'UTR shortening that stabilizes LYRM4 mRNA and elevates its expression. Increased LYRM4 expression promoted malignant phenotypes of non‐small cell lung cancer (NSCLC) cells through modulating ferroptosis, supporting
Meng Jin+11 more
wiley +1 more source
AU-Rich Long 3′ Untranslated Region Regulates Gene Expression in Bacteria
3′ untranslated regions (3′ UTRs) and particularly long 3′ UTRs have been shown to act as a new class of post-transcriptional regulatory element. We previously reported that hmsT mRNA stability is negatively regulated by the 3′ UTR of hmsT in Yersinia ...
Ju-Ping Zhao+3 more
doaj +1 more source
Human complement factor H. Two factor H proteins are derived from alternatively spliced transcripts [PDF]
The human complement factor H is an important component in the control of the alternative pathway of complement activation. We have previously shown that at least three factor H homologous mRNA species of 4.3 kb, 1.8 kb and 1.4 kb in length are ...
Alsenz+23 more
core +1 more source
Japanese encephalitis virus (JEV) employs a cap‐independent (CI) translation strategy to evade host translational shutoff. During the shut‐off of host cellular canonical translation, DEAD‐box protein 3 (DDX3) bind to JEV UTRs to establish a closed‐loop architecture, and its interaction with poly(A)‐binding protein 1 (PABP1) to form DDX3/PABP1/eIF4G ...
Chenxi Li+13 more
wiley +1 more source
Replication enhancer elements within the open reading frame of tick-borne encephalitis virus and their evolution within the Flavivirus genus [PDF]
We provide experimental evidence of a replication enhancer element (REE) within the capsid gene of tick-borne encephalitis virus (TBEV, genus Flavivirus).
Buckley, A.+5 more
core +3 more sources
SUMOylation is a Translatable Target in Hypoxic MNPs Regulating Retinal Vasculopathy
During ischemic retinopathy/retinal vasculopathy, UBC9‐mediated SUMOylation in retinal macrophages enhances their pro‐angiogenic capacity via hypoxia‐induced SUMOylation of FUS at K327/K502. This modification suppresses FUS binding to the Vegfa mRNA 3’UTR, stabilizing transcripts and facilitating VEGFA production. Targeting UBC9 inhibition can serve as
Zheng Zhong+9 more
wiley +1 more source
Lymphocytic choriomeningitis virus (LCMV) is a prototypic arenavirus. The function of untranslated regions (UTRs) of the LCMV genome has not been well studied except for the extreme 19 nucleotide residues of both the 5′ and 3′ termini. There are internal
Satoshi Taniguchi+15 more
doaj +1 more source
Cloning of the Complete Gene for Carcinoembryonic Antigen [PDF]
Carcinoembryonic antigen (CEA) is a widely used tumor marker, especially in the surveillance of colonic cancer patients. Although CEA is also present in some normal tissues, it is apparently expressed at higher levels in tumorous tissues than in ...
Bona, Marion+8 more
core
Evidence for widespread translation of 5′ untranslated regions
Abstract Ribosome profiling experiments support the translation of a range of novel human open reading frames. By contrast, most peptides from large-scale proteomics experiments derive from just one source, 5′ untranslated regions. Across the human genome we find evidence for 192 translated upstream regions, most of which would produce ...
Jose Manuel Rodriguez+5 more
openaire +2 more sources