Results 121 to 130 of about 249,320 (341)

Ovine PRNP untranslated region and promoter haplotype diversity

Journal of General Virology, 2009
The diversity and possible contribution of non-coding regions of the prion protein (PrP) gene (PRNP) to transmissible spongiform encephalopathy susceptibility and PrP regulation are not fully known. This study defined ten ovine PRNP promoters and five untranslated region (UTR) haplotypes found in atypical and classical scrapie cases and healthy control
Ginny C. Saunders, Anna C. Tout, Otto Windl, Susan J. Mountjoy, Saira Cawthraw, A. R. Sayers, Jim Hope   +6 more
openaire   +3 more sources

Identification of mRNA binding proteins that regulate the stability of LDL receptor mRNA through AU-rich elements[S]

Journal of Lipid Research, 2009
The 3′untranslated region (UTR) of human LDL receptor (LDLR) mRNA contains three AU-rich elements (AREs) responsible for rapid mRNA turnover and mediates the stabilization induced by berberine (BBR).
Hai Li, Wei Chen, Yue Zhou, Parveen Abidi, Orr Sharpe, William H. Robinson, Fredric B. Kraemer, Jingwen Liu   +7 more
doaj  

Untranslated regions (UTRs) are a potential novel source of neoantigens for personalised immunotherapy

Frontiers in Immunology
BackgroundNeoantigens, mutated tumour-specific antigens, are key targets of anti-tumour immunity during checkpoint inhibitor (CPI) treatment. Their identification is fundamental to designing neoantigen-directed therapy.
Christopher C. T. Sng, Ashwin Adrian Kallor, Benjamin S. Simpson, Georges Bedran, Javier Alfaro, Javier Alfaro, Javier Alfaro, Kevin Litchfield   +7 more
doaj   +1 more source

Complete nucleotide sequence of the influenza B/Singapore/222/79 virus hemagglutinin gene and comparison with the B/Lee/40 Hemagglutinin [PDF]

, 1983
The complete nucleotide sequence of the hemagglutinin (HA) gene of the human type B influenza virus B/Singapore/222/79 is presented. Comparison with the only other known sequence of a B hemagglutinin (B/Lee/40) shows that antigenic drift in type B HA ...
Fiers, Walter, Huylebroeck, Danny, Min Jou, Willy, Van Rompuy, Ludo, Verhoeyen, Martine   +4 more
core   +3 more sources

SUMOylation is a Translatable Target in Hypoxic MNPs Regulating Retinal Vasculopathy

Advanced Science, EarlyView.
During ischemic retinopathy/retinal vasculopathy, UBC9‐mediated SUMOylation in retinal macrophages enhances their pro‐angiogenic capacity via hypoxia‐induced SUMOylation of FUS at K327/K502. This modification suppresses FUS binding to the Vegfa mRNA 3’UTR, stabilizing transcripts and facilitating VEGFA production. Targeting UBC9 inhibition can serve as
Zheng Zhong, Guangyu Liang, Huimin Yu, Jiaqi Li, Ruohong Wang, Xiaohong Ma, Ziqing Zhou, Yin Zhao, Fei Sun, Xufang Sun   +9 more
wiley   +1 more source

Genetic characterization of the coxsackievirus B2 3′ untranslated region

Journal of General Virology, 2001
The secondary structure of the 3′ untranslated region (3′UTR) of picornaviruses is thought to be important for the initiation of negative-strand RNA synthesis. In this study, genetic and biological analyses of the 3′ terminus of coxsackievirus B2 (CVB2), which differs from other enteroviruses due to the presence of five additional nucleotides prior to ...
Charlotta Polacek, A. Michael Lindberg
openaire   +3 more sources

BCG‐Derived Outer Membrane Vesicles Induce TLR2‐Dependent Trained Immunity to Protect Against Polymicrobial Sepsis

Advanced Science, EarlyView.
B‐OMVs, nanoscale vesicles derived from BCG, are identified as effective and safe inducers of trained immunity that protect against sepsis. Through TLR2‐mediated metabolic and epigenetic reprogramming of hematopoietic stem cells, B‐OMVs enhance inflammatory response and phagocytic activity.
Yuan Gong, Wenyan Hao, Lingqi Xu, Yingyi Yang, Zhenzhen Dong, Peng Pan, Zhenjiang Bai, Jie Huang, Kaidi Yang, Zhu Jin, Rui Kang, Qiang Shan, Jiang huai Wang, Zijian Zhou, Daolin Tang, Jian Wang, Huiting Zhou   +16 more
wiley   +1 more source

Signals Involved in Regulation of Hepatitis C Virus RNA Genome Translation and Replication

Frontiers in Microbiology, 2018
Hepatitis C virus (HCV) preferentially replicates in the human liver and frequently causes chronic infection, often leading to cirrhosis and liver cancer.
Michael Niepmann, Lyudmila A. Shalamova, Lyudmila A. Shalamova, Gesche K. Gerresheim, Gesche K. Gerresheim, Oliver Rossbach   +5 more
doaj   +1 more source

Chromosomal Localization of the Carcinoembryonic Antigen Gene Family and Differential Expression in Various Tumors [PDF]

, 1988
Carcinoembryonic antigen (CEA) is a glycoprotein which is important as a tumor marker for a number of human cancers. It is a member of a gene family comprising about 10 closely related genes.
Fiebig, Heinz-Herbert, Kleist, Sabine von, Ortlieb, Barbara, Rudert, Fritz, Schempp, Werner, Shively, John E., Thompson, John A., Weber, Bernhard, Zimmermann, Wolfgang   +8 more
core   +1 more source

DeepSecMS Advances DIA‐Based Selenoproteome Profiling Through Cys‐to‐Sec Proxy Training

Advanced Science, EarlyView.
DeepSecMS, a deep learning platform leveraging a Cys‐to‐Sec proxy training strategy, enhances the identification of known selenoproteins and holds promise for discovering novel candidates. This proxy approach overcomes limitations associated with the rarity of known selenoproteins and demonstrates broad applicability in studying other rare protein ...
Chenfang Si, Yamei Yuan, Yu Zong, Liang Qiao, Wen‐Feng Zeng, Yaoyang Zhang   +5 more
wiley   +1 more source