Translational control by 5′-untranslated regions of eukaryotic mRNAs
Science, 2016 The eukaryotic 5′ untranslated region (UTR) is critical for ribosome recruitment to the messenger RNA (mRNA) and start codon choice and plays a major role in the control of translation efficiency and shaping the cellular proteome. The ribosomal initiation complex is assembled on the mRNA via a cap-dependent or cap-independent mechanism.
Hinnebusch, Alan G. +2 more
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Model‐Informed Drug Development Applications and Opportunities in mRNA‐LNP Therapeutics
Clinical Pharmacology &Therapeutics, EarlyView.The utilization of lipid nanoparticles (LNP) for encapsulating mRNA has revolutionized the field of therapeutics, enabling the rapid development of COVID‐19 vaccines and cancer vaccines. However, the clinical development of mRNA‐LNP therapeutics faces numerous challenges due to their complex mechanisms of action and limited clinical experience.
Jiawei Zhou +6 more
wiley +1 more source
Overexpression of miR-484 and miR-744 in Vero cells alters Dengue virus replication
Memorias do Instituto Oswaldo CruzBACKGROUND Dengue is considered one of the world’s most important mosquito-borne diseases. MicroRNAs (miRNAs) are small non-coding single-stranded RNAs that play an important role in the regulation of gene expression in eukaryotes.
Juan Camilo Castrillón-Betancur +1 more
doaj +1 more source
An element in the bovine papillomavirus late 3' untranslated region reduces polyadenylated cytoplasmic RNA levels [PDF]
, 1991 Priscilla A. Furth, Carl C. Baker
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Developmental Dynamics, EarlyView.Abstract Background The avian node is the equivalent of the amphibian Spemann's organizer, as indicated by its ability to induce a secondary axis, cellular contribution, and gene expression, whereas the node of the mouse, which displays limited inductive capacities, was suggested to be a part of spatially distributed signaling.
Braah Harmoush +2 more
wiley +1 more source
No evidence of a significant role for CTLA-4 in multiple sclerosis [PDF]
, 2006 Variation in the cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) gene plays a significant role in determining susceptibility to autoimmune thyroid disease and type 1 diabetes. Its role in multiple sclerosis is more controversial. In order to explore
Compston, A +7 more
core
Exploring the Potential and Advancements of Circular RNA Therapeutics
Exploration, EarlyView.Given the remarkable advantages in terms of stability, sustained expression profile, safety, wide range of druggable targets, scalable and cost‐effective manufacturing capabilities, circRNA is currently undergoing intensive investigation for various therapeutic applications such as vaccines, protein replacement, genetic disease treatment, gene therapy,
Lei Wang +6 more
wiley +1 more source
Multiple Instability-Regulating Sites in the 3′ Untranslated Region of the Urokinase-Type Plasminogen Activator mRNA [PDF]
, 1994 Rika Nanbu +2 more
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MiR‐29a/b Suppresses CD8+ T Cell Effector Function and Intestinal Inflammation
Exploration, EarlyView.Our findings suggest that miR‐29a/b is a critical regulator of CD8+ T cells, possibly via the Ifng‐JAK‐STAT signal in IBD patients and the upregulation of miR‐29a/b relieves the development of significant inflammation in the colon of DSS‐induced colitis‐affected mice.
Yingying Lin +27 more
wiley +1 more source
Cap-Independent Translation by the 5′ Untranslated Region of Theiler's Murine Encephalomyelitis Virus [PDF]
, 1993 openalex +1 more source