Specific binding of chloroplast proteins in vitro to the 3' untranslated region of spinach chloroplast petD mRNA. [PDF]
, 1991 H C Chen, David B. Stern
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Advanced Science, EarlyView.This study introduces two orthogonal sequencing methods, CMD1‐Deaminase sequencing (CD‐seq) and CMD1‐TET bisulfite sequencing (CT‐seq), that enable direct, independent detection of 5mC. Using these approaches together with ACE‐seq or TAB‐seq for 5hmC identification, the study reveals a significant reduction in 5hmC, but not 5mC, in the hippocampus of ...
Zi‐Xin Wang +15 more
wiley +1 more source
Overexpression of miR-484 and miR-744 in Vero cells alters Dengue virus replication
Memorias do Instituto Oswaldo CruzBACKGROUND Dengue is considered one of the world’s most important mosquito-borne diseases. MicroRNAs (miRNAs) are small non-coding single-stranded RNAs that play an important role in the regulation of gene expression in eukaryotes.
Juan Camilo Castrillón-Betancur +1 more
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CGM2, a Member of the Carcinoembryonic Antigen Gene Family is Down- Regulated in Colorectal Carcinomas [PDF]
, 1994 We have determined the precise chromosomal location, the exon structure, and the expression pattern of CGM2, a member of the carcinoembryonic antigen (CEA) gene family.
Craig, Ian +7 more
core
LncRNA TMEM99 Complexes with IGF2BP2 to Inhibit Autophagy in Lung Adenocarcinoma
Advanced Science, EarlyView.LncRNA TMEM99 is significantly upregulated in lung adenocarcinoma (LUAD) and correlates with poor prognosis. It promotes LUAD cell proliferation, migration, and invasion while suppressing autophagy. Mechanistically, TMEM99 binds FUBP3 and recruits IGF2BP2 in an m⁶A‐dependent manner to stabilize and enhance p21 mRNA translation, uncovering a novel ...
Zhigang Wu +12 more
wiley +1 more source
Gα16, a G Protein α Subunit Specifically Expressed in Hematopoietic Cells [PDF]
, 1991 Signal-transduction pathways mediated by guanine nucleotide-binding regulatory proteins (G proteins) determine many of the responses of hematopoietic cells.
Amatruda, Thomas T., III +3 more
core
Advanced Science, EarlyView.Self‐amplifying (saRNA), linear (linRNA), and circular (circRNA) mRNAs are compared under standardized conditions using lipid nanoparticles (LNPs) and pABOL polymer. saRNA achieved superior expression, while linRNA and circRNA performance varied based on untranslated region elements and delivery method.
Irafasha C. Casmil +12 more
wiley +1 more source
The deadenylation conferred by the 3' untranslated region of a developmentally controlled mRNA in Xenopus embryos is switched to polyadenylation by deletion of a short sequence element. [PDF]
, 1994 Philippe Bouvet +6 more
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Dynamic eIF3‐S6 Phase Separation Switch Instructed by m6A Modification Drives the Molting of Locusts
Advanced Science, EarlyView.This research reveals that reduced m6A modifications during insect molting trigger liquid–liquid phase separation (LLPS) of the m6A reader eIF3‐S6, which binds and stabilizes key molting mRNAs, including EcR and Cht10. Disrupting m6A or LLPS causes cuticle remodeling defects and molting failure, highlighting the synergistic control of gene expression ...
Zhihao Hu +8 more
wiley +1 more source
An element in the bovine papillomavirus late 3' untranslated region reduces polyadenylated cytoplasmic RNA levels [PDF]
, 1991 Priscilla A. Furth, Carl C. Baker
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