Results 181 to 190 of about 246,994 (340)

Multiplexed assays of human disease-relevant mutations reveal UTR dinucleotide composition as a major determinant of RNA stability

eLife
Untranslated regions (UTRs) contain crucial regulatory elements for RNA stability, translation and localization, so their integrity is indispensable for gene expression. Approximately 3.7% of genetic variants associated with diseases occur in UTRs, yet a
Jia-Ying Su, Yun-Lin Wang, Yu-Tung Hsieh, Yu-Chi Chang, Cheng-Han Yang, YoonSoon Kang, Yen-Tsung Huang, Chien-Ling Lin   +7 more
doaj   +1 more source

Acute kidney injury and iron metabolism: A narrative review focusing on pathophysiology and therapy

Smart Molecules, EarlyView.
Schematic illustration of acute kidney injury and iron metabolism (By Figdraw). Image for iron metabolism, including uptake, storage, utilization, export: Reproduced with permission. Abstract Acute kidney injury (AKI) represents a substantial challenge to public health and is characterized by elevated occurrence and fatality rates.
Xinyu Tan, Man Li, Jing Chen, Gang Liu, Zhixiang Lu   +4 more
wiley   +1 more source

CRISPR/Cas9‐edited tumor‐associated immune cells in cancer immunotherapy

VIEW, EarlyView.
Abstract Immuno‐oncology represents an emerging field that has significantly transformed tumor therapeutics, with immune cells serving as the cellular foundations of cancer immunotherapy. Due to its high efficiency and sensitivity, CRISPR/Cas9 genome editing is a highly promising technique for precise and rapid gene modification.
Yuhui Ma, Junxin Chen, Yuan Du, Zhihao Cao, Weizhi Ji, Yuyu Niu, Zebin Yang   +6 more
wiley   +1 more source

Unorthodox expression of an enzyme: evidence for an untranslated region within carA from Pseudomonas aeruginosa

, 1990
Sie Chuong Wong, Ahmed T. Abdelal
openalex   +1 more source

Novel polymorphism in the 5′-untranslated region of the interleukin-4 gene [PDF]

, 1999
Akira Takabayashi, Kenji Ihara, Yuka Sasaki, Koichi Kusuhara, Sankei Nishima, Toshiro Hara   +5 more
openalex   +1 more source

Impact of Acute Endurance Exercise on Alternative Splicing in Skeletal Muscle

FASEB BioAdvances, EarlyView.
Current model on the effects of acute endurance exercise on the AS regulatory mechanism with key trans‐factors/RBPs (e.g., hnRNP‐A1, ‐A3, and TIA1). ABSTRACT Alternative splicing (AS) is a highly conserved posttranscriptional mechanism, generating mRNA variants to diversify the proteome.
Alexander Ahn, Jeongjin J. Kim, Aaron L. Slusher, Jeffrey Y. Ying, Eric Y. Zhang, Andrew T. Ludlow   +5 more
wiley   +1 more source

Translational regulation and protein-coding capacity of the 5' untranslated region of human TREM2. [PDF]

Commun Biol, 2023
Yanaizu M, Adachi H, Araki M, Kontani K, Kino Y.   +4 more
europepmc   +1 more source

Sequences in the 3'-untranslated region of the human cellular glutathione peroxidase gene are necessary and sufficient for selenocysteine incorporation at the UGA codon

, 1993
Quan Shen, Fong‐Fong Chu, Peter E. Newburger   +2 more
openalex   +1 more source

An integrative strategy used by the aphid Uroleucon formosanum to counter host sesquiterpene lactone defense: Insights from combined genomic and transcriptomic analysis

Insect Science, EarlyView.
We report the first high‐quality chromosome‐level genome assembly for the aphid Uroleucon formosanum, a serious pest that infests lettuce in eastern Asia. A combination of comparative genomic analyses and RNA‐seq transcriptome profiling suggests that U. formosanum employs integrative mechanisms to cope with host plant‐derived sesquiterpene lactone (STL)
Jing‐Bo Li, Li‐Yun Jiang, Ge‐Xia Qiao, Jing Chen   +3 more
wiley   +1 more source

cba‐miR‐222‐3p involved in photoperiod‐induced apoptosis in testes of striped hamsters by targeting TRAF7

Integrative Zoology, EarlyView.
The cba‐miR‐222‐3p affects the MAPK signaling pathway by targeting TRAF7, thereby participating in the induction of apoptosis in the testes of striped hamsters under different photoperiods. Abstract The role of miRNAs in the regulation of seasonal reproduction in rodents, particularly in relation to photoperiod changes, is still poorly understood ...
Shuo WANG, Jinhui XU, Xingchen WANG, Mingdi WANG, Huiliang XUE, Ming WU, Chao FAN, Lei CHEN, Laixiang XU   +8 more
wiley   +1 more source