Results 181 to 190 of about 249,320 (341)

Multiplexed assays of human disease-relevant mutations reveal UTR dinucleotide composition as a major determinant of RNA stability

eLife
Untranslated regions (UTRs) contain crucial regulatory elements for RNA stability, translation and localization, so their integrity is indispensable for gene expression. Approximately 3.7% of genetic variants associated with diseases occur in UTRs, yet a
Jia-Ying Su, Yun-Lin Wang, Yu-Tung Hsieh, Yu-Chi Chang, Cheng-Han Yang, YoonSoon Kang, Yen-Tsung Huang, Chien-Ling Lin   +7 more
doaj   +1 more source

Vigilin, a Ubiquitous Protein with 14 K Homology Domains, Is the Estrogen-inducible Vitellogenin mRNA 3′-Untranslated Region-binding Protein [PDF]

, 1997
Robin E. Dodson, David J. Shapiro
openalex   +1 more source

The 5' untranslated region of the I factor, a long interspersed nuclear element-like retrotransposon of Drosophila melanogaster, contains an internal promoter and sequences that regulate expression.

, 1993
C. Mclean, Alain Bucheton, David Finnegan   +2 more
openalex   +1 more source

Identification of two proteins that bind to a pyrimidine-rich sequence in the 3'-untranslated region of GAP-43 mRNA [PDF]

, 1997
Nina Irwin, Veerle Baekelandt, Luda Goritchenko, Larry I. Benowitz   +3 more
openalex   +1 more source

Exploring the Potential and Advancements of Circular RNA Therapeutics

Exploration, EarlyView.
Given the remarkable advantages in terms of stability, sustained expression profile, safety, wide range of druggable targets, scalable and cost‐effective manufacturing capabilities, circRNA is currently undergoing intensive investigation for various therapeutic applications such as vaccines, protein replacement, genetic disease treatment, gene therapy,
Lei Wang, Lianqing Wang, Chunbo Dong, Jialong Liu, Guoxin Cui, Shan Gao, Zhida Liu   +6 more
wiley   +1 more source

Evolutionary conserved elements in the 5' untranslated region of β globin mRNA mediate site-specific priming of a unique hairpin structure during cDNA synthesis

, 1994
Vladimir Volloch, Bruce Schweitzer, Sophia Rits   +2 more
openalex   +2 more sources

MiR‐29a/b Suppresses CD8+ T Cell Effector Function and Intestinal Inflammation

Exploration, EarlyView.
Our findings suggest that miR‐29a/b is a critical regulator of CD8+ T cells, possibly via the Ifng‐JAK‐STAT signal in IBD patients and the upregulation of miR‐29a/b relieves the development of significant inflammation in the colon of DSS‐induced colitis‐affected mice.
Yingying Lin, Yuqi Wang, Yuning Zhang, Yao Lu, Juan Chen, Yongting Luo, Jian He, Qingfeng Luo, Heng Quan, Weiru Yu, Yujia Luo, Peng Xue, Yi Xue, Xiaoya Lin, Rui Ding, Lining Chen, Yiran Wang, Zenghui Xia, Liang Zhao, Hao Zhang, Ran Wang, Qingyu Wang, Xifan Wang, Jiaqi Su, Fazheng Ren, Cong Lv, Yixuan Li, Huiyuan Guo   +27 more
wiley   +1 more source

Endoplasmic Reticulum Stress Amplifies Cytokine Responses in Astrocytes via a PERK/eIF2α/JAK1 Signaling Axis

Glia, EarlyView.
ER stress amplifies TNF‐α, OSM, and IL‐1β responses in astrocytes. PERK and JAK1 signaling are required for the synergistic interaction between ER stress and inflammatory cytokines. Translational suppression attenuates the synthesis of the negative feedback regulators IκBα and SOCS3.
Anirudhya Lahiri, Savannah G. Sims, Jessica A. Herstine, Alicia Meyer, Micah J. Marshall, Ishrat Jahan, Subhodip Adhicary, Allison M. Bradbury, Gordon P. Meares   +8 more
wiley   +1 more source

Translational regulation and protein-coding capacity of the 5' untranslated region of human TREM2. [PDF]

Commun Biol, 2023
Yanaizu M, Adachi H, Araki M, Kontani K, Kino Y.   +4 more
europepmc   +1 more source

Identification of Two Novel Regulatory Elements within the 5′-Untranslated Region of the Human Sγ-Globin Gene [PDF]

, 1995
Persis Amrolia, John M. Cunningham, Paul A. Ney, Arthur W. Nienhuis, Stephen M. Jane   +4 more
openalex   +1 more source