Results 301 to 310 of about 249,320 (341)

Exploring the roles of conserved context‐dependent cis‐regulatory elements (cdCREs) in multicellularity, human health and disease

The FEBS Journal, EarlyView.
Conserved context‐dependent cis‐regulatory elements act as a major reservoir of disease‐associated polymorphisms in the human genome and are also affected by epigenetic change. This ‘state‐of‐the‐art’ review explores the latest developments in studying these enigmatic elements and how the effects of disease‐associated polymorphisms and environmentally ...
Andrew McEwan, Alexander Rattray, Greg Hutchings, Elizabeth Hay, Chris Murgatroyd, Alasdair MacKenzie   +5 more
wiley   +1 more source

NMR Studies of Genomic RNA in 3' Untranslated Region Unveil Pseudoknot Structure that Initiates Viral RNA Replication in SARS-CoV-2. [PDF]

JACS Au
Ohyama T, Osawa T, Sekine SI, Ishii Y.
europepmc   +1 more source

A 3′-Untranslated Region of Catalase Messenger-RNA Composed of a Stem-Loop and Dinucleotide Repeat Elements Binds a 69-kDa Redox-Sensitive Protein

, 1995
Linda Biadasz Clerch
openalex   +1 more source

TSC22D1 is a newly identified inhibitor of insulin secretion in pancreatic beta cells

The FEBS Journal, EarlyView.
TSC22D1 acts downstream of glucose signaling and negatively regulates insulin secretion in pancreatic beta cells. Mechanistically, TSC22D1 interacts with FoxO1. Elevated glucose levels enhance the TSC22D1–FoxO1 interaction indirectly by increasing the protein abundance of TSC22D1. Importantly, TSC22D1 and FoxO1 not only physically associate but also co‐
Sümbül Yıldırım, Amit Mhamane, Svenja Lösch, Annika Wieder, Ezgi Ermis, Ann‐Christine König, Sevgican Yilmaz, Stefanie M. Hauck, Fatih Kocabas, Julia Szendroedi, Stephan Herzig, Bilgen Ekim   +11 more
wiley   +1 more source

Additional prognostic value of polymorphisms within the 3'-untranslated region of programmed cell death pathway genes in early-stage breast cancer. [PDF]

Front Immunol
Chen H, Chen M, Zeng B, Tang L, Nie Q, Jin X, Guo W, Chen L, Lin Y, Wang C, Fu F.   +10 more
europepmc   +1 more source

Self‐Consumption Translation: Exploring Interlingual Translation Within Multilingual (mainland) China

International Journal of Applied Linguistics, EarlyView.
ABSTRACT Interlingual translation, as defined by Roman Jakobson, refers to the transfer of meaning between languages. However, this concept has often been conflated with linguistic shifts between distinct cultures and nation‐states. To challenge this misconception, I propose the concept of self‐consumption translation (SCT), a subfield of interlingual ...
Bilin (Belen) Liu
wiley   +1 more source

Characterization and optimization of 5´ untranslated region containing poly-adenine tracts in Kluyveromyces marxianus using machine-learning model. [PDF]

Microb Cell Fact
Zeng J, Song K, Wang J, Wen H, Zhou J, Ni T, Lu H, Yu Y.   +7 more
europepmc   +1 more source

Extracellular vesicles from adipose‐derived mesenchymal stem cells prevent high glucose‐induced retinal ganglion cell pyroptosis through a microRNA‐26a‐5p‐dependent mechanism

Journal of Diabetes Investigation, EarlyView.
ADSC‐EVs carrying miR‐26a‐5p confer protection against RGC pyroptosis by targeting HDAC4 and activating H3K27ac‐dependent Nrf2 expression. ABSTRACT Objective Mesenchymal stromal/stem cells have neuroprotective effects that limit damage to the retina, which is predominantly mediated by the released extracellular vesicles (EVs).
Lei Tang, Jian Zhang, Jianping Gao
wiley   +1 more source

Genome-Wide Analysis Reveals a Role of 3’-untranslated Region Variants Affecting Cleavage and Polyadenylation in Undiagnosed Rare Disorders

Kainov Y, Dias C, Hubbard T.
europepmc   +1 more source

Involvement of ribosomal protein L17 and Y-box binding protein 1 in the assembly of hepatitis C virus potentially via their interaction with the 3' untranslated region of the viral genome. [PDF]

J Virol
Liu J, Ito M, Liu L, Nakashima K, Satoh S, Konno A, Suzuki T.   +6 more
europepmc   +1 more source