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Regulation of gene expression by alternative untranslated regions
Trends in Genetics, 2006The untranslated regions of mRNAs can determine gene expression by influencing mRNA stability and translational efficiency. Recent reports show that gene expression can be regulated by the differential use of alternative untranslated regions. Tissue-specific expression of transcripts that have different untranslated regions (UTRs) can control protein ...
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The implications of structured 5′ untranslated regions on translation and disease
Seminars in Cell & Developmental Biology, 2005Translational control is a key step in eukaryotic gene expression. The majority of translational control occurs at the level of initiation, thus implicating the 5' untranslated region as a major site of translational regulation. Many growth-related mRNAs have atypical 5' UTRs, which are often long and GC-rich.
Pickering, Becky M., Willis, Anne E.
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Structural and functional features of eukaryotic mRNA untranslated regions
Gene, 2001The crucial role of the non-coding portion of genomes is now widely acknowledged. In particular, mRNA untranslated regions are involved in many post-transcriptional regulatory pathways that control mRNA localization, stability and translation efficiency.
Pesole G +5 more
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Molecular Immunology, 1992
We present here the nucleotide sequence of the gamma 2b membrane 3' untranslated region as well as approximately 443 nucleotides of 3' flanking sequence. Although this region contains two potential polyadenylation hexanucleotides AATAAA (located 1328 and 1407 nucleotides downstream of the last membrane exon), it appears that only the first site directs
Sherie L. Morrison, Susan B. Ward
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We present here the nucleotide sequence of the gamma 2b membrane 3' untranslated region as well as approximately 443 nucleotides of 3' flanking sequence. Although this region contains two potential polyadenylation hexanucleotides AATAAA (located 1328 and 1407 nucleotides downstream of the last membrane exon), it appears that only the first site directs
Sherie L. Morrison, Susan B. Ward
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Isolation of 5′-untranslational region of troutCYP1A1 gene
Archives of Pharmacal Research, 1996The genomic DNA was prepared from trout liver which was treated with 3-methycholanthrene, and cloned into lambda EMBL3, atBamH1 site. The genomic library constructed via infections of these recombinant phages intoE. coli K802, and screened by the most 5′-portion of trout CYP1A1 cDNA.
Yong Nam Roh, Yhun Yhong Sheen
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Characterization and evolution of 5′ and 3′ untranslated regions in eukaryotes
Gene, 2012Untranslated regions (UTRs) in eukaryotes play a significant role in the regulation of translation and mRNA half-life, as well as interacting with specific RNA-binding proteins. However, UTRs receive less attention than more crucial elements such as genes, and the basic structural and evolutionary characteristics of UTRs of different species, and the ...
Liu, Honglei +8 more
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Dehydrogenase Binding to the 3′-Untranslated Region of GLUT1 mRNA
Biochemical and Biophysical Research Communications, 1996Employing RNA gel mobility shift assays we detected specific binding events between several dehydrogenases and various regions of the GLUT1 mRNA 3'-untranslated region. In particular, the enzymes glyceraldehyde 3-phosphate dehydrogenase (G3PDH), lactate dehydrogenase (LDH), and glucose 6-phosphate dehydrogenase (G6PDH) bound to the GLUT1 3'-UTR while ...
Kevin M. McGowan, Phillip H. Pekala
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Bioinformatics Approaches for Studying Untranslated Regions of mRNAs
2008Interactions between RNA-binding proteins and cis-acting elements in the 5'- and 3'-untranslated regions (UTRs) of transcripts are responsible for regulating essential biological activities, such as mRNA localization, mRNA turnover, and translation efficiency.
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The role of the 3’ untranslated region in breast cancer
2018Our genes and the way in which our genetic code is read makes us who we are. Unfortunately, our genetic code can be altered or misinterpreted in cancer. The 3’ untranslated region is one such example of an important part of our genetic code that is read differently in cancer.
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The 3′ untranslated regions of chloroplast genes in
MGG Molecular & General Genetics, 1996Ruth Rott +3 more
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