Results 31 to 40 of about 15,644 (263)

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

open access: yesMolecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson   +9 more
wiley   +1 more source

Mechanics of educational influence: The Recursive gDZIK Model [PDF]

open access: yesStudia z Teorii Wychowania
This article proposes a new approach to the definition of upbringing, bringing the academic understanding of the term closer to the social practices that form its essence. I present a model in which upbringing is seen as a process of actively, though not
Piotr Kowzan
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch   +13 more
wiley   +1 more source

O ROZUMIENIU, WDRAŻANIU I POTRZEBIE WYCHOWANIA MORSKIEGO. WYCHOWANIE MORSKIE W OPINIACH NAUCZYCIELI Z WOJEWÓDZTWA ZACHODNIOPOMORSKIEGO

open access: yesStudia Maritima, 2017
One of the interests of maritime sociology beside the maritime professions, social maritime processes, seaside communities has been for decades maritime upbringing. The idea of maritime upbringing as well as the activities associated with it have been
Arkadiusz Kołodziej   +1 more
doaj   +1 more source

Circulating tumor cell viability during and after radiotherapy mirrors treatment response in cancer patients

open access: yesMolecular Oncology, EarlyView.
Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy   +10 more
wiley   +1 more source

The Relationship Between Pediatric Residents' Experiences Being Parented and Their Provision of Parenting Advice

open access: yesFrontiers in Pediatrics, 2018
Background: Factors surrounding pediatricians' parenting advice and training on parenting during residency have not been well studied. The Resident Parenting Questionnaire (RPQ) was developed to assess (a) the relationship between pediatric residents ...
Ami C. Bax   +3 more
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

open access: yesMolecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober   +16 more
wiley   +1 more source

Contemporary Areas of Christian Pedagogy

open access: yesPaedagogia Christiana, 2014
The text investigates the issue of contemporary fields of Christian pedagogy, distinguished on the basis of its identity and the specific character of its scope. The author starts off with the identity of this sub-discipline.
Katarzyna Olbrycht
doaj   +1 more source

Weakening the nuclear envelope: Lamin B receptor in melanoma metastasis

open access: yesMolecular Oncology, EarlyView.
LBR‐driven nuclear fragility supports melanoma invasion. A: Melanocyte presents low LBR (Lamin B Receptor) levels, maintaining nuclear integrity and lamina‐chromatin tethering. B: During malignant progression, upregulation of LBR clusters at the INM (Inner Nuclear Membrane) during confined migration causes local lamina weakening and cholesterol ...
Francesca Lorenzini   +1 more
wiley   +1 more source

Pragmatic Liberalism and Modernization of Upbringing

open access: yesВопросы образования, 2014
Upbringing is regarded as a purposeful training to teach human values. By definition, upbringing engages the deep-lying moral attitudes of people, the moral and cultural values that have always been disputed by the society. Upbringing inevitably involves
Alexandr Sidorkin
doaj   +1 more source

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