Results 61 to 70 of about 225,900 (285)

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Upbringing without Goals?

Paedagogia Christiana, 2012
Human existence is specific in that it involves upbringing based on setting goals, which people attain or strive to attain over a shorter or longer period of time. Such goals are necessary for people and their upbringing.
Marian Nowak
doaj   +1 more source

What Constitutes Intermarriage for Multiracial People in Britain? [PDF]

, 2015
Intermarriage is of great interest to analysts because a group’s tendency to partner across ethnic boundaries is usually seen as a key indicator of the social distance between groups in a multiethnic society.
Ali Suki, Bratter Jennifer., Ford Rob, Gallagher Charles, Gordon Milton, Ifekwunigwe Jayne, Mahtani Minelle, Miri Song, Morning Ann, Muttarak Raya, Nandi Alita, Office for National Statistics, Platt Lucinda, Rockquemore Kerry Ann, Root Maria, Song Miri, Song Miri, Spickard Paul, Tizard Barbara   +18 more
core   +2 more sources

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

Meta-theory vs. meta-theories of education [PDF]

Studia z Teorii Wychowania
The subject of the analysis is the genesis and evolution of the study of the theory of upbringing as a monistic, orthodox subdiscipline of education sciences and its evolution in Poland towards the differentiation of contemporary theories of upbringing ...
Bogusław Śliwerski
doaj   +1 more source

Impact of a senior research thesis on students' perceptions of scientific inquiry in distinct student populations

FEBS Open Bio, EarlyView.
This study addressed how a senior research thesis is perceived by undergraduate students. It assessed students' perception of research skills, epistemological beliefs, and career goals in Biochemistry (science) and BDC (science‐business) students. Completing a thesis improved confidence in research skills, resilience, scientific identity, closed gender‐
Celeste Suart, Haley L. Zubyk, Michelle Ogrodnik, Caitlin E. Mullarkey, Felicia Vulcu   +4 more
wiley   +1 more source

Same-Sex Marriage and Other Moral Taboos: Cultural Acceptances, Change in American Public Opinion and the Evidence from the Opinion Polls [PDF]

, 2017
This article analyzes the evolution of gay and lesbian rights and same-sex marriage in American public opinion. It describes how Obergefell v. Hodges, state-level decisions and the public opinion trends can be considered as the outcome of a grassroots ...
Morini, Marco
core   +4 more sources

Navigating new norms: a systematic review of factors for the development of effective digital tools in higher education

FEBS Open Bio, EarlyView.
What factors make for an effective digital learning tool in Higher Education? This systematic review identifies elements of a digital tool that published examples reveal to be features of an engaging and impactful digital tool. A systematic literature search yielded 25 research papers for analysis.
Akmal Arzeman, Jessica Haines, Connie Pritchard, Stephen Rutherford, Nigel Francis   +4 more
wiley   +1 more source

The correlation between the child’s morbidity and family relations

Проблеми сучасної психології, 2018
The problem of frequency and types of child’s (up to 6 years) morbidity in the relation with emotional state of family members and style of upbringing is considered in the article.
T. Y. Zimovina, A. S. Filchakova
doaj   +1 more source