Results 61 to 70 of about 230,999 (335)

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Following in Your Parents' Footsteps? Empirical Analysis of Matched Parent-Offspring Test Scores [PDF]

, 2009
In this paper, we explore whether an intergenerational relationship exists between the reading and mathematics test scores, taken at ages 7, 11 and 16, of a cohort of individuals born in 1958 and the equivalent test scores of their offspring measured in ...
Brown, S., McIntosh, S., Taylor, K.
core   +1 more source

What Constitutes Intermarriage for Multiracial People in Britain? [PDF]

, 2015
Intermarriage is of great interest to analysts because a group’s tendency to partner across ethnic boundaries is usually seen as a key indicator of the social distance between groups in a multiethnic society.
Ali Suki, Bratter Jennifer., Ford Rob, Gallagher Charles, Gordon Milton, Ifekwunigwe Jayne, Mahtani Minelle, Miri Song, Morning Ann, Muttarak Raya, Nandi Alita, Office for National Statistics, Platt Lucinda, Rockquemore Kerry Ann, Root Maria, Song Miri, Song Miri, Spickard Paul, Tizard Barbara   +18 more
core   +2 more sources

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Upbringing without Goals?

Paedagogia Christiana, 2012
Human existence is specific in that it involves upbringing based on setting goals, which people attain or strive to attain over a shorter or longer period of time. Such goals are necessary for people and their upbringing.
Marian Nowak
doaj   +1 more source

Tumor‐stromal crosstalk and macrophage enrichment are associated with chemotherapy response in bladder cancer

FEBS Open Bio, EarlyView.
Chemoresistance in bladder cancer: Macrophage recruitment associated with CXCL1, CXCL5 and CXCL8 expression is characteristic of Gemcitabine/Cisplatin (Gem/Cis) Non‐Responder tumors (right side) while Responder tumors did not show substantial tumor‐stromal crosstalk (left side). All biological icons are attributed to Bioicons: carcinoma, cancerous‐cell‐
Sophie Leypold, Janik Riese, Lancelot Seillier, Mark Kühnel, Julia Pannhausen, Charlotte O. J. Fröhlich, Christian Martin, Peter Boor, Matthias Saar, Danny D. Jonigk, Nadine T. Gaisa, Michael Rose   +11 more
wiley   +1 more source

Meta-theory vs. meta-theories of education [PDF]

Studia z Teorii Wychowania
The subject of the analysis is the genesis and evolution of the study of the theory of upbringing as a monistic, orthodox subdiscipline of education sciences and its evolution in Poland towards the differentiation of contemporary theories of upbringing ...
Bogusław Śliwerski
doaj   +1 more source

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

FEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida, Kazuya Kusama, Ayaka Horiuchi, Yu Kawaguchi, Atsuya Tsuru, Mikihiro Yoshie, Kazuhiro Tamura   +6 more
wiley   +1 more source

Iron homeostasis disruption and lipid peroxidation in skeletal muscle during short‐term immobilization

FEBS Open Bio, EarlyView.
14‐day casting‐induced immobilization reduced gastrocnemius muscle mass and increased non‐heme iron and ferritin heavy chain levels. Despite iron accumulation, transferrin receptor 1 and iron regulatory protein 2 were paradoxically upregulated. Lipid peroxidation was elevated without compensatory antioxidant responses.
Haruka Yokogawa, Kazuhiko Higashida, Naoya Nakai   +2 more
wiley   +1 more source

Przemoc w wychowaniu w świetle opinii społecznej oraz relacji rodziców – zarys problemu na tle raportu Rzecznika Praw Dziecka

Problemy Wczesnej Edukacji, 2015
The paper describes the results of the survey focused on the social attitudes towards violence in upbringing made in 2015. The survey is a means of monitoring violence against children carrying out by the Ombudsman for Children since 2011.
Ewa Jarosz, Cezary Kurkowski
doaj   +1 more source