Results 101 to 110 of about 547,836 (276)

5MW Power Upgrade Studies of the ISIS TS1 Target [PDF]

, 2015
The increasing demand for neutron production at the ISIS neutron spallation source has motivated a study of an upgrade of the production target TS1.
Booth, Christopher N., Bungau, Adriana, Bungau, Cristian, Cywinski, R., Edgecock, Thomas R., Zang, Lei   +5 more
core  

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Study of the d$E$/d$x$ resolution of a GEM Readout Chamber prototype for the upgrade of the ALICE TPC

, 2017
The ALICE Collaboration is planning a major upgrade of its central barrel detectors to be able to cope with the increased LHC luminosity beyond 2020.
Mathis, Andreas
core   +2 more sources

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Network Control System Upgrade and Reconnection Modificationof CCQG Light Railway Vehicle

机车电传动, 2014
Control principle, merits and drawbacks of CCQG light railway vehicle existing network control system were expounded, andbased above, upgrade and reconnection modification scheme was presented.
ZHOU Xiao, LIU Yan-hui, HUANG Wei, MA Yu-fan   +3 more
doaj  

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

The FNAL injector upgrade

, 2011
The present FNAL H- injector has been operational since the 1970s and consists of two magnetron H- sources and two 750 keV Cockcroft-Walton Accelerators.
/Fermilab, Bollinger, D.S., Duel, K.L., Lackey, J.R., Pellico, W.A., Tan, C.Y.   +5 more
core   +1 more source

Light Ion Accelerating Line (L3IA): Test Experiment at ILIL-PW

, 2018
The construction of a novel Laser driven Light Ions Acceleration Line(L3IA) is progressing rapidly towards the operation, following the recent upgrade of the ILIL-PW laser facility.
Baffigi, F., Brandi, F., Bussolino, G., Cristoforetti, G., Fazzi, A., Fulgentini, L., Giove, D., Gizzi, L. A., Koester, P., Labate, L., Maero, G., Palla, D., Romé, M., Tomassini, P.   +13 more
core   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

High Resolution BPM Upgrade for the ATF Damping Ring at KEK

, 2012
A beam position monitor (BPM) upgrade at the KEK Accelerator Test Facility (ATF) damping ring has been accomplished, carried out by a KEK/FNAL/SLAC collaboration under the umbrella of the global ILC R&D effort.
/Fermilab, /KEK, Tsukuba, Briegel, C., Eddy, N., Fellenz, B., Gianfelice-Wendt, E., Prieto, P., Rechenmacher, R., Semenov, A., Terunuma, N., Voy, D., Wendt, M., Zhang, D.   +12 more
core   +1 more source