Results 71 to 80 of about 547,836 (276)

Novel Silicon n-on-p Edgeless Planar Pixel Sensors for the ATLAS upgrade

, 2013
In view of the LHC upgrade phases towards HL-LHC, the ATLAS experiment plans to upgrade the Inner Detector with an all-silicon system. The n-on-p silicon technology is a promising candidate for the pixel upgrade thanks to its radiation hardness and cost ...
Bagolini, A., Bomben, M., Boscardin, M., Bosisio, L., Calderini, G., Chauveau, J., Giacomini, G., La Rosa, A., Marchori, G., Zorzi, N.   +9 more
core   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Problem of Presence of the Railway Rolling Stock in the Republic of Belarus. Recycle, Car Building, Tests

Механика машин, механизмов и материалов, 2012
The problem of security of conveyances by a railway rolling stock in Republic of Belarus and the basic ways of its solution is observed. It is specified, that working capacity maintenance, improvement of park of carriages by conducting of capitally ...
V.I. Senko , A.V. Putsiata
doaj  

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Long Term Outcomes and Predictors of Reverse Remodelling After Cardiac Resynchronization Therapy Upgrade

Medicina
Background and Objectives: Upgrades to cardiac resynchronization therapy (CRT) account for approximately one quarter of all CRT indications. Although recent clinical trials have demonstrated significant clinical benefits of upgrade procedures, data on ...
Jakub Simka, Eva Cermakova, Rudolf Praus, Jiri Dokoupil, Jakub Stritecky, Ludek Haman, Filip Varhanik, Radek Pudil, Petr Parizek   +8 more
doaj   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Intolerance to physiologic pacing following upgrade of long term ventricular pacing: A drawback of routine upgrade

The Egyptian Heart Journal, 2012
Background: Upgrade from VVI(R) to physiologic pacing offers benefit to patients with pacemaker syndrome (PMS). However, in asymptomatic patients with long term ventricular pacing little is known regarding potential early hazards related to the acute ...
Hayam El-Damanhoury, Osama Diab
doaj   +1 more source

The Ooty Wide Field Array

, 2017
We describe here an ongoing upgrade to the legacy Ooty Radio Telescope (ORT).The ORT is a cylindrical parabolic cylinder 530mx30m in size operating at a frequency of 326.5 (or z ~ 3.35 for the HI 21cm line).
Chengalur, Jayaram. N., Manoharan, P. K., Subrahmanya, C. R.   +2 more
core   +1 more source

Australia: Engagement upgrade [PDF]

Nature, 2016
The value that Australia places on publication quality over quantity has elevated it into the top echelon of science. Can it now improve its flagging track record in commercialization?
openaire   +2 more sources

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source