Results 91 to 100 of about 82,838 (255)

Cerium Nanoparticle‐Mediated Inhibition of the NSUN2/m5C Axis Suppresses Synovial Aggression in Rheumatoid Arthritis

Advanced Science, EarlyView.
A novel epitranscriptomic mechanism in rheumatoid arthritis is uncovered: NSUN2 promotes disease via m5C‐dependent stabilization of ICMT mRNA, fueling the migration and invasion of pathogenic RA FLS. Targeting this axis with engineered nanoparticles (Ce/SAA NPs) effectively inhibits disease progression, presenting a precise therapeutic strategy ...
Ruiru Li, Simin Chen, Huijuan Hu, Shiyao Wu, Jingnan Wang, Kai Sun, Chenxi Peng, Suling Liu, Shuoyang Zhang, Yu Kuang, Wei Chen, Qian Qiu, Liuqin Liang, Yu Wen, Hanshi Xu, Youjun Xiao   +15 more
wiley   +1 more source

Psychological Stress Associated Bile Acid Reprogramming Promotes Hepatocellular Carcinoma Progression

Advanced Science, EarlyView.
Depression is increasingly recognized as a risk factor for chronic diseases, yet its biological impact on cancer remains unclear. Using data from more than 490 000 participants across three international cohorts, we show that depression significantly increases the risk of liver cancer.
Ruijiang Zeng, Mengmeng Wang, Kang Wang, Zhuo Xing, Yulong Hong, Tongtong Li, Geng Zong, Chong Yang, Dan Zhang, Zhangling Chen, Xin Jin   +10 more
wiley   +1 more source

Bioengineered Exosome‐Loaded Immunomodulatory Bioadhesive Spray Reverses Liver Fibrosis and Metabolic Dysfunction That Triggers Beneficial Gut‐Liver Crosstalk in Chronic Fatty Liver Disease

Advanced Science, EarlyView.
Umbilical cord stem cell‐derived exosomes encapsulated in an immunomodulatory bioadhesive hydrogel spray enable localized therapy, sustained vesicle delivery, macrophage polarization, suppress systemic inflammation, and mitigate glucose and insulin homeostasis impairments in MAFLD.
Triya Saha, Ayushi Mairal, Shreya Mehrotra, Shiv K. Sarin, Ashok Kumar   +4 more
wiley   +1 more source

The UPLC–ESI–QqQLIT–MS/MS method for quantitative determination of phytochemicals in ethanolic extracts of different parts of eight Ficus species: Development and validation

International Journal of Food Properties, 2018
Ficus and validation of the ultra performance liquid chromatography–electrospray ionization hybrid triple quadrupole–linear ion trap–tandem mass spectrometry (UPLC–ESI–QqQLIT–MS/MS) method in a multiple-reaction monitoring (MRM) mode for the quantitative
Sunil Kumar, Awantika Singh, Arun K. Kushwaha, Rinkey Tiwari, Lal B. Chaudhary, Mukesh Srivastava, Brijesh Kumar   +6 more
doaj   +1 more source

Multi‐tissue Metabolic GWAS and Drought‐Responsive Multi‐omics Reveal the Genetic Basis of the Quinoa Metabolome

Advanced Science, EarlyView.
A multi‐omics framework combining multitissue genome‐wide association studies, metabolomics, transcriptomics, proteomics, and functional validation uncovers the genetic basis of specialized metabolism in quinoa. The study identifies hundreds of metabolite‐associated loci, prioritizes candidate genes for saponin, betalain, and flavonoid biosynthesis ...
Julia von Steimker, Elodie L. Rey, Clara Stanschewski, Regina Wendenburg, Annabella Klemmer, Markéta Macho, Venkatesh P. Thirumalaikumar, Noha O. Saber, Aleksandra Skirycz, Alisdair R. Fernie, Mark Tester, Saleh Alseekh   +11 more
wiley   +1 more source

ANALIZA AKRILAMIDA UPLC MS/MS TEHNIKOM

, 2019
Akrilamid je molekula male molarne mase korištena kao industrijsko kemijski reagens. Poliakrilamid iz plastike degradira u akrilamid u prisutnosti sunčeve svjetlosti, željezo III iona, UV radijacije, povišene temperature te dezinfekcije. Jedan od izvora akrilamida je i dim cigarete.
Vučenović, Marina, Dubrović, Igor, Salać Nataša, Mićović, Vladimir, Mrakovčić-Šutić, Ines, Brčić Karačonji, Irena, Šutić, Ivana, Bulog, Aleksandar   +7 more
openaire   +2 more sources

Comprehensive Analysis of Sinomenii caulis and Menispermi rhizoma Based on Ultra‐High Performance Liquid Chromatography and Ultra‐High Performance Liquid Chromatography‐Quadrupole Time‐of‐Flight‐Mass Spectrometry

Analytical Science Advances
Sinomenii caulis (SC) and Menispermi rhizoma (MR) are Chinese herbal medicines from the same family and are often confused. To achieve identification of SC and MR, the paper used the differential chemical components and the combination characteristics of
Ye Tao, Xinyue Zhang, Wen Li, Zhe Wu, Shuchen Duan, Lizhi Wan, Xiangri Li, Yazhong Zhang, Xianlong Cheng, Feng Wei   +9 more
doaj   +1 more source

Determination of Aflatoxins in Grains by QuEChERS-UPLC-MS/MS

Liang you shipin ke-ji
A method based on a QuEChERS sample preparation approach coupled with ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) was established to determine six aflatoxins (B1, B2, G1, G2, M1, M2) residues in grains.
WU Qin-yan, ZHANG Wen-wen, LIANG Hong-fang, WANG Jian-hua, CHEN Lu   +4 more
doaj   +1 more source

A New UPLC-MS/MS Method Validated for Quantification of Jervine in Rat Plasma and the Study of Its Pharmacokinetics in Rats

Journal of Analytical Methods in Chemistry, 2019
The aim of this study was to develop an ultraperformance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) method to assess the concentration of jervine in rat plasma and its pharmacokinetics. Diazepam was used as internal standard (IS).
Lianguo Chen, Qinghua Weng, Jianshe Ma
doaj   +1 more source

LRRC4 Orchestrates AP2A1‐Containing Clathrin‐Coated Vesicles to Disrupt Mitochondrial Cristae and Restrict Glioblastoma Progression

Advanced Science, EarlyView.
LRRC4 suppresses GBM by regulating AP2A1‐containing Golgi‐derived clathrin‐coated vesicles. Low LRRC4 allows cytoplasmic AP2A1 to maintain mitochondrial fission‐fusion, MICOS integrity, and OXPHOS, promoting proliferation and invasion. High LRRC4 redirects AP2A1‐containing Golgi‐derived clathrin‐coated vesicles to mitochondria, disrupts MICOS, enhances
Yang Li, Cheng Huang, Liangqi Jiang, Zhen Li, Qing Liu, Minghua Wu   +5 more
wiley   +1 more source