Results 61 to 70 of about 84,087 (308)

Multi‐Method Geophysical Surveys Between and Around the Kerlescan and the Manio Megalithic Alignments in Carnac (Morbihan, France)

Archaeological Prospection, EarlyView.
ABSTRACT The Carnac alignments in Morbihan (France) are among the most famous Neolithic sites of the world. Paradoxically, they have benefited little from a thorough renewal of archaeological data over the past century. There are many reasons for this, but it is mainly because the site has been regarded more as a monument to visit and protect than as ...
Guillaume Bruniaux, Vivien Mathé, Olivier Agogué, Sylvia Lopez, Philippe Paillou, Reena Perschke, Vincent Ard   +6 more
wiley   +1 more source

Janus kinase 2 inhibition by pacritinib as potential therapeutic target for liver fibrosis

Hepatology, EarlyView., 2022
Diagram of the activation of the profibrotic and procontractile Janus kinase 2 (JAK2)/Ras homolog family member A/Rho‐kinase pathway and the inhibition of phosphorylated JAK2 by pacritinib to inhibit hepatic stellate cell activity. Abstract Background and Aims Janus kinase 2 (JAK2) signaling is increased in human and experimental liver fibrosis with ...
Sandra Torres, Cristina Ortiz, Nadine Bachtler, Wenyi Gu, Leon D. Grünewald, Nico Kraus, Robert Schierwagen, Christoph Hieber, Caroline Meier, Olaf Tyc, Maximilian Joseph Brol, Frank Erhard Uschner, Bart Nijmeijer, Christoph Welsch, Marie‐Luise Berres, Carmen Garcia‐Ruiz, Jose Carlos Fernandez‐Checa, Christian Trautwein, Thomas J. Vogl, Stefan Zeuzem, Jonel Trebicka, Sabine Klein   +21 more
wiley   +1 more source

Content Analysis of Responses From an INSAR Special Interest Group (SIG): Indigenous Perspectives on Autism

Autism Research, EarlyView.
ABSTRACT Autism remains understudied and under‐detected in Indigenous communities across the globe. This content analysis investigates key themes and future directions for Indigenous autism research, as discussed during a Special Interest Group at the 2025 International Society for Autism Research meeting in Seattle, United States.
Grant Bruno, Annie Tang, Troy Q. Boucher, Emily Coombs, T. C. Waisman, Anne Lindblom   +5 more
wiley   +1 more source

Combinatorial targeting of G‐protein‐coupled bile acid receptor 1 and cysteinyl leukotriene receptor 1 reveals a mechanistic role for bile acids and leukotrienes in drug‐induced liver injury

Hepatology, EarlyView., 2022
CHIN117 is a dual cysteinyl leukotriene receptor 1 (CYSLTR1) antagonist and G‐protein‐coupled bile acid receptor 1 (GPBAR1) agonist. In the liver, GPBAR1 and CYSLTR1 are coexpressed by liver sinusoidal endothelial cells (LSECs), HSCs, circulating monocytes/macrophages, and liver resident macrophages (Kupffer cells).
Michele Biagioli, Silvia Marchianò, Cristina di Giorgio, Rosalinda Roselli, Martina Bordoni, Rachele Bellini, Bianca Fiorillo, Valentina Sepe, Bruno Catalanotti, Chiara Cassiano, Maria Chiara Monti, Eleonora Distrutti, Angela Zampella, Stefano Fiorucci   +13 more
wiley   +1 more source

Uplift Behavior of Suction Bucket Foundations in Sands: Experimental and Numerical Investigations

Journal of Marine Science and Engineering
Suction bucket foundations offer efficient installation and reusability for offshore wind turbines, yet their uplift behavior in sands with different permeabilities remains insufficiently understood. This study investigates the uplift behavior of suction
Xin Wang, Xueliang Zhao, Weiming Gong, Yangyang Li, Wenni Deng   +4 more
doaj   +1 more source

The Role of Microbiota Metabolites Propionic Acid, p‐Cresol, and 4‐Ethylphenyl Sulfate in Autism Susceptibility: A Systematic Review

Autism Research, EarlyView.
ABSTRACT The etiopathogenesis of Autism Spectrum Disorder (ASD) encompasses complex interactions between genetic and environmental risk factors. The high prevalence of gastrointestinal disorders in autistic individuals has propelled a growing interest in the possible involvement of gut dysbiosis in ASD pathogenesis.
Laura Sandoni, Lisa Asta, Nicole Giompaolo, Rinvil Renaldi, Alberto Amaretti, Maddalena Rossi, Antonio M. Persico   +6 more
wiley   +1 more source

Experimental And Numerical Investigations On Uplift Behaviour Of Plate Anchors In Cohesionless Soil [PDF]

, 2013
In this study, series of small scale laboratory pull-out tests were conducted on anchors embedded in sand. Model tests were performed in a test box. The effects of embedment ratioof anchor plates and relative density of sand on uplift capacity behaviour ...
Mustafa Laman, Selcuk Bildik
core  

Geotechnical design with apparent seismic safety factors well-bellow 1 [PDF]

, 2014
The paper demonstrates that whereas often in seismic geotechnical design it is not realistically feasible to design with ample factor of safety against failure as is done in static design, an "engineering" apparent seismic factor of safety less than 1 ...
Anastasopoulos, Apostolou, Chen, Chopra, Cremer, Drosos, Evangelia Garini, Gajan, Garini, Gazetas, Gazetas, Gelagoti, George Gazetas, Gerolymos, Harden, Ioannis Anastasopoulos, Makris, Mergos, Newmark, Panagiotidou, Paolucci, Priestley, Priestley, Sarma, Shirato, Taylor, Villaverde, Zhang   +27 more
core   +3 more sources

Immunoinformatics‐Based Design of a Multi‐Epitope Vaccine Targeting a Conserved Copper–Associated Protein in Neisseria gonorrhoeae

Biotechnology and Applied Biochemistry, EarlyView.
ABSTRACT Neisseria gonorrhoeae poses an urgent public health challenge due to rapidly increasing antimicrobial resistance and the absence of an effective vaccine. Targeting conserved bacterial pathways involved in essential physiological processes may provide new opportunities for vaccine antigen discovery.
Sinethemba H. Yakobi, Uchechukwu U. Nwodo   +1 more
wiley   +1 more source

Clinical pharmacology and prescribing education: An updated medical school curriculum from the British Pharmacological Society

British Journal of Clinical Pharmacology, EarlyView.
Aims Prescribing is a complex, essential skill that doctors must acquire to practice medicine safely and effectively. The British Pharmacological Society has historically provided a core curriculum to guide clinical pharmacology and prescribing education in UK medical schools.
Dagan O. Lonsdale, Clare Guilding, Jennifer Koenig, Michael Okorie, Reecha Sofat, Simon Maxwell   +5 more
wiley   +1 more source