Results 101 to 110 of about 172,963 (284)
Wireless Capsule Device for Targeted and Safe Tissue Biopsy with Integrated Sensing
Advanced Materials Technologies, EarlyView.This work presents a capsule device featuring a novel magnetically controlled biopsy mechanism for enhanced safety. The biopsy unit integrates a foldable linkage with dual magnets, creating a magnetic attraction–based safeguard, preventing unintended activation during locomotion. A flexible sensor provides real‐time penetration displacement sensing for
Kiyoung Kim +5 more
wiley +1 more source
Advanced Materials Technologies, EarlyView.This paper investigates magnetic soft actuators for aerospace use. Various actuators with different magnetic particle fractions are created and tested to enhance their multifunctional performance, specifically displacement ability and mechanical strength, which significantly improved their mechanical strength by incorporating natural and synthetic ...
Diogo Santos +3 more
wiley +1 more source
Advanced Science, EarlyView.Rheumatoid arthritis is a disease characterized by joint inflammation. Approximately 50% of patients show insufficient response to traditional synthetic disease‐modifying antirheumatic drugs. This study aims to elucidate differential molecular profiles of the mechanisms underlying drug responses through multi‐omics strategy.
Congcong Jian +26 more
wiley +1 more source
CriticalCity Upload. Intervista a Augusto Pirovano e Matteo Uguzzoni
G|A|M|E The Italian Journal of Game Studies, 2012 CriticalCity Upload è prima di tutto un progetto di trasformazione urbana concepito in chiave creativa. Se si volesse cucirgli addosso un’etichetta sarebbe quella di urban transformation game, ramificazione della numerosa famiglia dei pervasive games. Il
Alida Scussolin
doaj
Advanced Science, EarlyView.This study employed tRNASUAG, an anticodon‐engineered tRNA (ACE‐tRNA), to introduce a phosphorylatable serine into the C‐terminal domain of HBc by reading through its stop codon, thereby potentially promoting the ubiquitin‐proteasome degradation of HBc, and subsequently inhibiting HBV replication. Through a tRNASUAG‐gHBV1‐tRNASUAG‐gHBV2‐tRNASUAG tandem
Xingwen Yang +7 more
wiley +1 more source
Prickle4 Drives Microenvironmental Remodeling and Resistance to Parp Inhibition in IDH‐Mutant Glioma
Advanced Science, EarlyView.IDH‐mutant gliomas exhibit sensitivity to PARP inhibitors (PARPi) owing to oncometabolite 2‐HG‐induced DNA repair defects. PARPi treatment induces resistance by upregulating Prickle4, which promotes VEGF‐driven angiogenesis. Combining PARPi veliparib with anti‐angiogenic lenvatinib blocks this pathway, causing tumor regression and prolonged survival in
Ju Yang +16 more
wiley +1 more source
SMob scoping review data for Zenodo upload
, 2023 Lindsay M. Gorrell +2 more
openalex +2 more sources
Advanced Science, EarlyView.In the present study, it is found that in osteosarcoma, lactate‐activated HCAR1 promotes β‐arrestin 2 translocation from cytoplasm to nucleus. In the nucleus, β‐arrestin 2 recruits PP2A to the activated STAT1/2 dimers, mediating STAT1/2 dephosphorylation and inhibiting the transcription of downstream anti‐oncogenes to promote OS progression.
Zhitao Han +26 more
wiley +1 more source
Advanced Science, EarlyView.Macrophages infiltrate the spinal cord post‐injury, decreasing over time. Microglia phagocytose myelin debris, increasing lipid accumulation. Macrophage deletion improves outcomes, while microglial deletion worsens them. The LD+ microglia subtype shows abnormal Pparg signaling.
Mingran Luo +17 more
wiley +1 more source