Results 261 to 270 of about 535,815 (352)

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SCD‐plus features and AD biomarkers in cognitively unimpaired samples: A meta‐analytic approach for nine cohort studies

Alzheimer's &Dementia, EarlyView.
Abstract INTRODUCTION Specific features of subjective cognitive decline (SCD‐plus) have been proposed to indicate an increased risk of preclinical Alzheimer's disease (AD). However, few studies have examined how these features relate to AD biomarkers in cognitively unimpaired (CU) older adults. METHODS Meta‐analyses were performed using cross‐sectional
Elizabeth Kuhn, Hannah M. Klinger, Rebecca E. Amariglio, Michael Wagner, Frank Jessen, Emrah Düzel, Michael T. Heneka, Gael Chételat, Dorene M. Rentz, Reisa A. Sperling, Jarith L. Ebenau, Elke Butterbrod, Wiesje M. Van Der Flier, Sietske A. M. Sikkes, Charlotte E. Teunnissen, Argonde C. Van Harten, Elsmarieke M. Van De Giessen, Lorena Rami, Adria Tort, Gonzalo Sánchez Benavides, Katherine A. Gifford, Carol Van Hulle, Rachel F. Buckley, Alzheimer's Disease Neuroimaging Initiative, Australian Imaging Biomarkers and Lifestyle flagship study of ageing, A4 Study Team, DELCODE Study, Harvard Aging Brain Study, Frederic Brosseron, Katharina Buerger, Christoph Laske, Robert Perneczky, Oliver Peters, Joseph Priller, Alfredo Ramirez, Anja Schneider, Annika Spottke, Stefan Teipel, Jens Wiltfang   +38 more
wiley   +1 more source

An optimal peer selection for peer-to-peer video content distribution using fuzzy linear programming approach. [PDF]

PeerJ Comput Sci
Anandaraj M, S N.
europepmc   +1 more source

Brassinin from Brassica campestris L. inhibits colorectal cancer by inducing p62/NRF2/GPX4‐regulated ferroptosis

Animal Models and Experimental Medicine, EarlyView.
BSN suppresses the cell viability of colorectal cancer by inducing GPX4‐regulated ferroptosis. BSN may bind to NRF2 protein to inactivate the NRF2 signaling, inhibiting the expression of p62 and HO‐1. Abstract Background Indole phytoalexins, plant‐derived compounds present in cruciferous vegetables, have demonstrated anticancer properties.
Shi‐Yuan Wen, Rui‐Rui Gao, Yan‐Yan Chen, Yi‐Jie Wang, Xin‐Tong Wang, Hai‐Xin Liu   +5 more
wiley   +1 more source

Coping mechanisms for students with mental disorders: An exploratory qualitative study at Busitema University's Mbale and Busia Campuses. [PDF]

PLOS Glob Public Health
Kagoya EK, Mpagi J, Waako P, Muhwezi MRL, Namaganda A, Nsubuga AG, Atala CE, Okello F, Okibure A, Kibuuka R, Wandera E, Ndamanywa K, Kirabira J.   +12 more
europepmc   +1 more source

Yunweiling alleviates functional constipation: integrating network pharmacology and experimental study

Animal Models and Experimental Medicine, EarlyView.
In a study combining network pharmacological analysis and experimental verification, yunweiling has been shown improve functional constipation by inhibiting the PI3K‐Akt‐p53 signaling pathway and reducing the expression of TP53. Abstract Background This study investigated the impacts and mechanisms of yunweiling in the management of Functional ...
Peng Zhang, Wei Li, Weiwen Zheng, Jinwen Liu, Nuonan She, Xia Chen, Weibo Wen   +6 more
wiley   +1 more source

Assessment of the quality and reliability of YouTube videos related to teleradiology in musculoskeletal and rheumatic diseases: a cross-sectional study. [PDF]

Rheumatol Int
Yemeshev Y, Bekaryssova D, Kocyigit BF.
europepmc   +1 more source

Astaxanthin ameliorates benzalkonium chloride–induced dry eye disease through suppressing inflammation and oxidative stress via Keap1‐Nrf2/HO‐1 signaling pathways

Animal Models and Experimental Medicine, EarlyView.
The flowchart of this research. Abstract Background Dry eye disease (DED) predominantly results from elevated tear film osmolarity, which can not only cause ocular inconvenience but may lead to visual impairments, severely compromising patient well‐being and exerting substantial economic burdens as well.
Ziyu Liu, Yaqiong Li, Jiayu Bao, Siyuan Li, Ya Wen, Peng Zhang, Jun Feng, Yinghui Wang, Lei Tian, Ying Jie   +9 more
wiley   +1 more source

Binding‐Site Purification of Actives (B‐SPA) Enables Efficient Large‐Scale Progression of Fragment Hits by Combining Multi‐Step Array Synthesis With HT Crystallography

Angewandte Chemie, EarlyView.
“Ne te lave pas, j'arrive.” No work‐up or purification required! Cheap robotics‐based high throughput synthesis of crude reactions mixtures, married to high throughput X‐Ray crystallography, leads to savings in time, energy and solvent use, and was applied to fragment elaboration vs the atypical bromodomain PHIP(2).
Harold Grosjean, Anthony Aimon, Storm Hassell‐Hart, Warren Thompson, Lizbé Koekemoer, James Bennett, Anthony Bradley, Cameron Anderson, Conor Wild, William J. Bradshaw, Edward A. FitzGerald, Tobias Krojer, Oleg Fedorov, Philip C. Biggin, John Spencer, Frank von Delft   +15 more
wiley   +2 more sources

Association of middle cerebral artery aneurysms and variation of the A1 segment. [PDF]

PLoS One
Li X, Yue X, Xie Z, Nie L, Huang G, Peng Y, Gu J, Lai C, Gao H.   +8 more
europepmc   +1 more source