Results 91 to 100 of about 4,766,069 (305)

Advanced Materials for Biologics Delivery to Brain Tumors

Advanced Materials, EarlyView.
Material innovation is central to unlocking the therapeutic potential of biologics against many central nervous system diseases, including brain cancer. By engineering carriers with controlled transport, targeting, and release properties, advanced materials can overcome the blood–brain barrier and tumor microenvironment, improving the delivery of ...
Yuran Feng, Yuxue Cao, Maria Kavallaris, Taskeen Janjua, Amirali Popat   +4 more
wiley   +1 more source

Prediction of patients at high risk of upper gastrointestinal cancer for endoscopy using artificial intelligent technology

, 2021
Background: Endoscopic screening for early detection of upper gastrointestinal (UGI) cancer (oesophageal and stomach cancer) is important. However, population-based endoscopic screening is difficult to implement in populous countries. By identifying high-
Liu, Y, He, X, Lin, D, Chen, H, Lin, Y
core  

Intelligent Micro/Nanorobots for Targeted Interventional Therapy: From Bench to Clinic

Advanced Robotics Research, EarlyView.
Zirui Zhang et al. reviewed the application and challenges of mobile nanomachines in interventional therapy. By converting exogenous energy, including chemical, magnetic, optical, and ultrasonic sources, into mechanical forces, micro/nanorobots (MNRs) enable precise actuation at unprecedented scales. Evolving far beyond traditional drug delivery, these
Zirui Zhang, Yu Dong, Yongsheng Du, Rui Gao, Lin Zhang, Fei Tong   +5 more
wiley   +1 more source

Frailty and Upper Gastrointestinal Surgery: Initial Findings from Thailand’s First Surgical Frailty Study

Siriraj Medical Journal
Objective: Thailand’s aging population has led to an increase in elderly patients undergoing major surgery. Frailty is a key predictor of adverse surgical outcomes, but its impact in Thai patients remains underreported. This study aimed to determine the
Gritin Gonggetyai, Nathawadi Techalertsuwan, Chawisa Nampoolsuksan, Thammawat Parakonthun, Jirawat Swangsri, Asada Methasate, Arunotai Siriussawakul, Onuma Chaiwat, Varalak Srinonprasert   +8 more
doaj   +1 more source

Enhancing Super‐Resolution Spatial Transcriptomics Data by Transfer Learning

Advanced Science, EarlyView.
SpotZoomer employs a transfer‐learning‐based strategy to enhance the resolution of Visium data by leveraging available high‐resolution priors. The resulting super‐resolved maps enable sharper delineation of cell boundaries and more precise inference of cell–cell communication patterns that would otherwise remain obscured at native resolution.
Xiaoyu Li, Lihua Zhang, Wenwen Min
wiley   +1 more source

Cancer survival in Cixian of China, 2003–2013: a population‐based study

Cancer Medicine, 2018
Cixian is one of the high‐risk areas for upper gastrointestinal cancer in China and the world. From 2005, comprehensive population‐based screening for upper gastrointestinal cancers has been conducted in Cixian.
Dongfang Li, Daojuan Li, Guohui Song, Di Liang, Chao Chen, Yachen Zhang, Zhaoyu Gao, Yutong He   +7 more
doaj   +1 more source

Gastric Cardia Cancer; The Most Common Type of Upper Gastrointestinal Cancer in Ardabil, Iran: An Endoscopy Clinic experience [PDF]

Background-According to a recent report published by the Ministry of Health and Medical Education of the I. R. of Iran, gastric cancer (GC) is the most common fatal cancer in this country and its prevalence is highest in Ardabil province, Northwest of ...
درخشان, محمدحسین, ملک زاده, رضا, عرشی, شهنام, سجادی, علیرضا, یزدانبد, عباس   +4 more
core  

Disrupting Helicobacter pylori Iron Homeostasis With Bismuth Nanodrug‐Mediated Nutritional Trap for Targeted Gastric Infection Therapy

Advanced Science, EarlyView.
A “nutritional trap” strategy centered on disrupting bacterial iron homeostasis is proposed. The synthesized Bi‐TP@FU (TBF) can target Helicobacter pylori, interfere with the bacterial iron uptake and utilization processes to disrupt its iron homeostasis, induce bacterial death, and meanwhile preserve the balance of the intestinal flora.
Tianye Fang, Jinzhe Tong, Feng Feng, Cong Liu, Chang Shu, Jiaying Zhu, Shibo Zhang, Shuyue Deng, Wanchao Zuo, Yuhan Song, Jun Yang, Yanmin Ju, Yingying Xing, Jianjun Dai   +13 more
wiley   +1 more source

Cancer‐Associated BCL‐2 Mutants Reveal Mechanisms Towards Venetoclax Resistance

Advanced Science, EarlyView.
Venetoclax (VEN) resistance in chronic lymphocytic leukemia arises from diverse BCL2 mutations. We map mechanisms contributing to VEN resistance across common BCL‐2 variants. G101V and D103Y reduce drug binding and increase sequestration of pro‐apoptotic proteins. V156D blocks VEN allosterically.
Jonas Aufdermauer, Ian de Ridder, Mahjoobeh Ehsani, Marasim Khan, Justin Kale, Lukas P. Frenzel, David Andrews, Spyridoula Karamanou, Ana J. Garcia‐Saez, Geert Bultynck   +9 more
wiley   +1 more source

Worldwide Impact of Upper Gastrointestinal Disease in Familial Adenomatous Polyposis

Diagnostics
Familial adenomatous polyposis (FAP) is the most common hereditary colorectal adenomatous polyposis and cancer syndrome which has historically been associated with a near absolute risk of colorectal cancer.
Mahnur Haider, Muaaz Masood, Bryson W. Katona, Carol A. Burke, Gautam N. Mankaney   +4 more
doaj   +1 more source