Results 71 to 80 of about 2,799,641 (305)

AARS1‐Mediated H3K27 Lactylation Rewires Glycolysis to Sustain Aggressive and Recurrent Bladder Cancer

Advanced Science, EarlyView.
AARS1 drives PI3K–AKT–mTOR‐dependent glycolysis in bladder cancer, promoting lactate accumulation, increased lactylation, H3K27la enrichment at the HK2 promoter, and HK2 transcription. HK2 reinforces glycolysis, sustaining a metabolic–epigenetic program associated with tumor progression, recurrence, and metastasis.
Qin Yuan, Tianbao Song, Yipeng He, Sihan Xia, Yaoqiu Huang, Wenlin He, Qin Yi, Zefeng Wang, Peihan Wang, Chenbo Huang, Linzhi Li, Zhen Yin, Fan Cheng, Weimin Yu   +13 more
wiley   +1 more source

Sarcoidosis with upper respiratory tract involvement

, 2006
The aim of the study was to investigate the upper respiratory tract as a site of extrapulmonary sarcoidosis. Diagnosis of sarcoidosis with upper respiratory tract involvement was performed on the basis of clinical, laboratory, radiographic and ...
CINTORINO M., GINANNESCHI C., BARGAGLI E., CARUSO G., ROTTOLI P., NUTI D., CHIDICHIMO C.   +6 more
core   +2 more sources

Magnitude and factors associated with upper respiratory tract infection among under-five children in public health institutions of Aksum town, Tigray, Northern Ethiopia: an institutional based cross-sectional study

The Pan African Medical Journal, 2020
INTRODUCTION: Upper respiratory tract infection is a leading cause of morbidity among under five, particularly in the developing countries. Delays in the identification and treatment of under-fives are among the main contributors to the complication. The
Teklay Zeru, Hagos Berihu, Gerezgiher Buruh, Haftom Gebrehiwot   +3 more
doaj   +1 more source

A General High‐Throughput Mucus Microrheology Platform for Quantitative and Scalable Mucus Phenotyping

Advanced Science, EarlyView.
High‐throughput Differential Dynamic Microscopy measures frequency‐resolved mechanical fingerprints from 3 to 10 μL$\umu{\rm L}$ mucus samples using only a few minutes of operator attention per sample. This automated analysis enables scalable mucus phenotyping for translational research by distinguishing mechanical heterogeneity among donors, disease ...
Feng Ling, Ayşe Tuğçe Şahin, Bernardo Miller Naranjo, Stefano Aime, Doris Roth, Anna Pukaluk, Niels Tepho, Romina Augustin, Benedetta Zampa, Andrea S. Vendrame, Mark‐Christian Klassen, Ellen Emken, Marion Kiechle, Mircea Gabriel Stoleriu, Pontus Mertsch, Ruth Olmer, Yohannes Tesfaigzi, Oliver Lieleg, Janna C. Nawroth   +18 more
wiley   +1 more source

Emergence of respiratory Streptococcus agalactiae isolates in cystic fibrosis patients [PDF]

, 2009
Streptococcus agalactiae is a well-known pathogen for neonates and immunocompromized adults. Beyond the neonatal period, S. agalactiae is rarely found in the respiratory tract. During 2002–2008 we noticed S. agalactiae in respiratory secretions of 30/185
Vera Eickel, Brandt Claudia, Kahl, Barbara, Barbara Spellerberg, Reinisch Beatrice, Eickel, Vera, Angelika Dübbers, Eickel Vera, Peter Küster, Dübbers, Angelika, Brandt, Claudia, Küster Peter, Reinisch, Beatrice, Beatrice Reinisch, Dübbers Angelika, Spellerberg Barbara, Küster, Peter, Kahl Barbara, Barbara Kahl, Claudia Brandt, Spellerberg, Barbara   +20 more
core   +1 more source

A Robust Bio‐Supportive Hydrogel Patch for Full‐Thickness Repair of Gastroesophageal Defects

Advanced Science, EarlyView.
Gastroesophageal defect repair remains a formidable clinical challenge plagued by high leakage and life‐threatening complications. We develop a double‐disc, highly crystalline PVA‐based RBS hydrogel patch featuring suture‐free sealing, robust acid/enzyme resistance and mechanical durability.
Xingqi Song, Zhewei Shuai, Weiyan Sun, Liang Chen, Yiwei Shen, Jiateng Hu, Yuanqi Ma, Jie Luo, Meilin Huang, Yan Luo, Yunlang She, Guangdong Zhou, Chang Chen, Dong Lei   +13 more
wiley   +1 more source

Recurrent upper and lower respiratory tract infections in children: Assessment of predictive value in tuberculosis and HIV coinfection

Acta Biomedica Scientifica
Background. In phthisiology, all recurrent respiratory tract infections are considered risk factors for tuberculosis (TB) in children. A differentiated assessment of the predictive value of recurrent upper and lower respiratory tract infections will ...
S. N. Shugaeva, L. P. Pashkova, E. I. Vasilyeva, S. G. Zvonkova, O. G. Koshkina, O. B. Ogarkov   +5 more
doaj   +1 more source

Bacterial communities of the upper respiratory tract of turkeys

Scientific Reports, 2021
The respiratory tracts of turkeys play important roles in the overall health and performance of the birds. Understanding the bacterial communities present in the respiratory tracts of turkeys can be helpful to better understand the interactions between ...
Olimpia Kursa, Grzegorz Tomczyk, Anna Sawicka-Durkalec, Aleksandra Giza, Magdalena Słomiany-Szwarc   +4 more
doaj   +1 more source

H4K12 Lactylation Regulates NDUFS7 to Drive Microglia Reverse Electron Transport in Spinal Cord Injury

Advanced Science, EarlyView.
Lactate accumulation after SCI promotes H4K12la lactylation, which upregulates NDUFS7, triggering mitochondrial RET and ROS, enforcing pro‐inflammatory microglial polarization. MM@mPTC, a biomimetic nanotherapeutic, degrades LDHA in activated microglia, reducing H4K12la lactylation and blocking RET, thus curbing ROS, fostering a reparative phenotype ...
Chenglong Hong, Zhichen Jiang, Zhouwei Wu, Chenyu Wu, Jiang Liu, Kaijie Guo, Yihui Liang, Shaobo Xu, Yuchen Jin, Yong Xiao, Lei Guo, Hui Xu, Sunren Sheng, Chenggui Wang   +13 more
wiley   +1 more source

Extensive upper respiratory tract sarcoidosis.

, 2016
Sarcoidosis is a chronic granulomatous disease of unknown aetiology. It can affect any part of the organism, although the lung is the most frequently affected organ. Upper airway involvement is rare, particularly if isolated.
Soares, M, Sousa, C, Garanito, L, Freire, F   +3 more
core   +1 more source