A bimetallic Mn–Ca nanoreactor (MCC) is developed as a non‐nucleotide STING nanoagonist for cancer metalloimmunotherapy. MCC induces Ca2+ overload and hydroxyl radical generation, resulting in mitochondrial damage and mtDNA release. The released mtDNA cooperates with Mn2+ to robustly activate cGAS–STING signaling.
Xin Wang Mo +7 more
wiley +1 more source
The problem posed by exam choice on the comparability of results in the Finnish matriculation examination [PDF]
The article by Kupiainen, Marjanen and Hautamäki focuses on the upper secondary matriculation examination in Finland as a school leaving and university entrance examination. The presented research addresses the question of whether increased choice of the
Hautamäki, Jarkko Juhana +2 more
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In situ TEM uncovers the atomic‐scale mechanisms underlying hydrogen‐driven γ‐Fe2O3→Fe3O4→FeO reduction. In γ‐Fe2O3, oxygen vacancies cluster around intrinsic Fe vacancies, leading to nanopore formation, whereas in Fe3O4, vacancy aggregation is suppressed, preserving a dense structure.
Yupeng Wu +14 more
wiley +1 more source
Assessing inquiry skills of upper secondary school students
Inquiry-based science education (IBSE) has been in the focus of educational systems all over Europe in the last years. The main idea connected with IBSE is that students are involved in the process of learning by conducting activities to answer research questions similar way as it is done in science.
Zuzana Ješková +2 more
openaire +1 more source
Purcell‐Enhanced Spectrally Precise Emission in Dual‐Microcavity Organic Light‐Emitting Diodes
Spectrally precise emission from broadband organic light‐emitting diodes is realized via a dual‐microcavity strategy. This architecture achieves narrowband emission (full width at half maximum, FWHM = 21 nm) with ultrapure color approaching BT.2020 by enhancing the Purcell effect via coupling of excitons with dual‐microcavity resonance.
Jun Yong Kim +3 more
wiley +1 more source
Upper Secondary School Pupils' Experience of a Lifestyle Plan Based on Physical Power, Mental Harmony, and Social Capacity. [PDF]
Lygnegård F +2 more
europepmc +1 more source
Readiness to teach secondary mathematics: A study of pre-service mathematics teachers\u27 self-perceptions [PDF]
This study evaluated pre-service teachers’ (PSMTs) perceptions of their own readiness to teach secondary mathematics. The study was conducted at an Australian university across two campuses, in different states.
Hine, Gregory S.C., Thai, Thuan
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Synthetic Nanobiology Actuated Lipometabolic Cell Factory for Autologous Tumor Immunotherapy
FA plays a crucial role in the interaction between tumor cells and the tumor microenvironment, especially for the immune response. A biocatalytic immunoenhancement strategy is developed to boost antitumor immunity by FA metabolic orientation to ceramide. Through the design of this delicate catalytic immunoenhancement strategy, the synthetic nanobiology
Shoujie Zhao +8 more
wiley +1 more source
Parental Risk Attitudes and Children's Secondary School Track Choice [PDF]
It is well known that individuals' risk attitudes are related to behavioral outcomes such as smoking, portfolio decisions, and also educational attainment, but there is barely any evidence on whether parental risk attitudes affect the educational ...
Guido Heineck, Oliver Wölfel
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Upper secondary school dropout : lessons from central Java province, Indonesia : a dissertation presented in partial fulfilment of the requirement for the degree of Doctor of Philosophy in Economics at Massey University, Manawatū, New Zealand [PDF]
One of the biggest challenges in educational reform is dealing with the problem of school dropout. It is not merely due to poor grades or bad behaviour or human capital considerations; often it is a more complex problem.
Setyadharma, Andryan
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