Results 251 to 260 of about 1,448,033 (306)

De Novo Design and Directed Evolution Refinement of Mirror‐Image Protein Binders Targeting Interleukin‐4

Advanced Science, EarlyView.
This study presents the de novo design and directed evolution of a mirror‐image D‐protein inhibitor targeting human interleukin‐4 (IL‐4). The engineered molecule exhibits nanomolar binding affinity for IL‐4 and effectively inhibits IL‐4–mediated signaling.
Liqing Xu, Yuxiang Ren, Tongyue Wang, Hongyong Li, Yue Yao, Lei Liu, Ke Sun, Peilong Lu   +7 more
wiley   +1 more source

Recurrent secondary milia after full-thickness skin graft using retroauricular donor skin for dog-bite defect: a case report. [PDF]

Arch Craniofac Surg
Kim MW, Keum CR, Seo KS, Seo JY.
europepmc   +1 more source

pH/ROS‐Responsive Injectable Hydrogel Co‐Loaded with B7‐H3 Blocker and NETs Suppressor Boosts OSCC Synergistic Immunotherapy

Advanced Science, EarlyView.
A pH/ROS‐dual‐responsive injectable hydrogel, formed by dynamic boronic ester and Schiff base crosslinking, co‐delivers enoblituzumab (B7‐H3 blocker) and Cl‐amidine (NETs suppressor). Via localized intratumoral delivery, it synergistically reprograms the immunosuppressive tumor microenvironment, overcomes T cell infiltration barriers, restores ...
Huan Li, Yun Li, Yating Hu, Yanbing Yao, Yaodong He, Jing Li, Jiaqi Tang, Zhenyan Zhao, Yan Wang, Yulun He, Xiaolong Zhang, Xinjie Yang, Jianhua Wei   +12 more
wiley   +1 more source

The Role of Psychological Inflexibility in Adolescents' Loneliness: School Friendship Closeness as a Mediator. [PDF]

Scand J Psychol
Jormanainen A, Kalttila K, Hämäläinen T, Lappalainen P, Tunkkari M, Kiuru N.   +5 more
europepmc   +1 more source

OCIAD2 Stabilizes Integrin β1 Signaling Through SNX17‐Mediated Endosomal Recycling to Lipid Rafts and Modulates Cisplatin Response in HNSCC

Advanced Science, EarlyView.
This study identifies OCIAD2 as a critical regulator of cisplatin resistance in HNSCC. Mechanistically, OCIAD2 stabilizes integrin β1 through a direct physical interaction and facilitates its SNX17‐dependent endosomal recycling to lipid raft microdomains. Targeting OCIAD2 disrupts integrin β1 trafficking and significantly enhances cisplatin sensitivity,
Li Cui, Shanshan Si, Min Ye, Pei Lin, Meiyan Zou, Yunfan Lin, Xu Chen, Bing Guo, Wenjuan Sun, Xinyuan Zhao   +9 more
wiley   +1 more source

Trajectories of school absenteeism in adolescents with recurrent pain: predictors and distal outcomes. [PDF]

Pain Rep
Owiredua C, Flink I, Evans B, Boersma K.
europepmc   +1 more source

Food procurement in upper secondary schools in a Norwegian county: nutritional quality and environmental impacts. [PDF]

Food Nutr Res
Bjøntegaard MM, Paulsen MM, van Oort B, Andersen LF.   +3 more
europepmc   +1 more source

Kolb learning styles in Tactical Combat Casualty Care (TCCC): a comparative study of military learners and civilian paramedics. [PDF]

BMC Emerg Med
Günsoy E, Selman F, Aykut A, Yıldırım C, Tatlı M.   +4 more
europepmc   +1 more source

Invasive Pulmonary Aspergillosis in a Young Adult With Hyperimmunoglobulin E Syndrome and Hypogammaglobulinemia Following Rituximab Therapy. [PDF]

Cureus
Pandrangi GK, Golechha RN, Mills LR, Brown JT, Helmstetter N.   +4 more
europepmc   +1 more source

From knowledge to action: strengthening cancer prevention knowledge in schools among adolescents in Germany. [PDF]

BMC Public Health
Erickson N, Rupp I, Baurecht H, Welker C, Mumm F, Mück C, Jost N, Kesting SV, Holzem A, Heinzerling L, Algül H, Heinemann V, Fey T, Holch JW.   +13 more
europepmc   +1 more source