Impact of trial exclusion criteria on real-world comparative effectiveness of targeted therapies in rheumatoid arthritis: the FIRST Registry. [PDF]
Kubo S +10 more
europepmc +1 more source
Digital twins to accelerate target identification and drug development for immune‐mediated disorders
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley +1 more source
Temporal variation in markers of immune signaling and wound repair in primary human airway epithelial cells following acute versus repeated woodsmoke condensate exposure. [PDF]
Hickman E +6 more
europepmc +1 more source
Upsetting Of Tri-Metallic St-Cu-Al And St-Cu60Zn-Al Cylindrical Billets
Işık Çetintav +2 more
openalex +2 more sources
5‐Aminolevulinic acid combined with ferric ammonium citrate (5‐ALA/FAC) stimulates dermal papilla cell activity and promotes hair follicle growth. The treatment enhances ERK and AKT signaling, increases hair‐inductive gene expression, and restores dermal papilla function suppressed by dihydrotestosterone and oxidative stress, resulting in enhanced hair
Han‐Wook Ryu, Eok‐Soo Oh, Sewoon Kim
wiley +1 more source
Uncovering the relationship between the human ocular surface microbiome and gut microbiome. [PDF]
Eldridge N +5 more
europepmc +1 more source
Workability in Rolling and Upsetting of Cast Chromium
Yasunori Harada +2 more
openalex +2 more sources
Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke +4 more
wiley +1 more source
Modeling injury severity among motor vehicle occupants using a safe system-aligned, population-based framework: evidence from Ohio crash data (2017-2023). [PDF]
Harden AL +7 more
europepmc +1 more source

