Results 51 to 60 of about 225 (196)

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

Special aspects of recording thermomechanical impact processesduring high-voltage capacitor discharge welding

Frontier Materials & Technologies
The application of hybrid technologies allows improving welding productivity by reducing welding material con-sumption, edge preparation time, heat input, and, consequently, the probability of crack formation.
Stanislav V.Nescoromniy
doaj   +1 more source

Genetic algorithm based optimization of friction welding process parameters on AA7075-SiC composite

Engineering Science and Technology, an International Journal, 2019
Friction welded joints of Aluminium metal matrix composite is witnessing tremendous developments in aeronautical and marine applications. The aim of this work is to optimize the process parameters of the rotary friction welding of Al-SiC composite.
K.S. Sreenivasan, S. Satish Kumar, Jeeva Katiravan   +2 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Ночное апноэ у пациентов с артериальной гипертензией и метаболическим синдромом. Влияние сипап-терапии

Архивъ внутренней медицины, 2014
In recent years in cardiology actively studied the problem of breathing during sleep in connection with the fact that accumulate more and more data on the value of breathing during sleep in the development of cardiovascular disease, including fatal ...
Т. Н. Ермолаева
doaj   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Positive equilibrium in USA - China relations: durable or not?

Janus.net, 2011
Repeated episodes of Chinese public pressure against the United States during 2009 and 2010 on a wide range of issues involving seas near China, Taiwan, Tibet, and economic disputes are subject to different interpretations but on balance they do not seem
Robert Sutter
doaj  

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

A comparative study of stress among students of medicine, engineering, and nursing

Indian Journal of Psychological Medicine, 2011
Background: In today′s ultra competitive environment, students face more stress than ever - be it related to studies, examination, peer, teachers or parent′s pressure.
Shashank P Behere, Richa Yadav, Prakash B Behere   +2 more
doaj   +1 more source