Results 41 to 50 of about 689,520 (364)

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Urea-Assisted Reconstitution of Discoidal High-Density Lipoprotein

, 2020
High-density lipoprotein (HDL) is a naturally occurring composite of lipids and lipid-binding proteins. The cholate dialysis method, first reported by Jonas in 1969, is the most widely used approach for reconstituting discoidal HDL (dHDL) in test tubes ...
Minoru Nakano (1500658), Ayumi Sumino (1294521), Tatsuya Murakami (1495675), Ryosuke Fukuda (140110), Mio Saito (8692605), Shiori Shibukawa (8692608)   +5 more
core   +1 more source

Bayesian approach for evaluating ammonia volatilization nitrogen losses in fertilizers applied to coffee plants [PDF]

Ciência e Agrotecnologia
Ammonia loss through volatilization is an important reason for the lower effectiveness of nitrogen fertilizers in coffee plants. The Bayesian approach uses informative prior distributions, which help improve the precision and accuracy of inferences ...
Mírian Rosa, Tales Jesus Fernandes, Adriele Aparecida Pereira   +2 more
doaj   +1 more source

Mineral Nitrogen Release Patterns in Various Soil and Texture Types and the Impact of Urea and Coated Urea Potassium Humate on Barley Biomass

Soil Systems, 2023
Controlled-release urea fertilization is an innovative approach and effective means to reduce the loss of nitrogen and enhance fertilizer use efficiency to optimize crop yield while minimizing the environmental impact.
Samar Swify, Romas Mažeika, Jonas Volungevičius   +2 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

COMPARATIVE STUDY: CORRELATION OF UREA AND SERUM CREATININE WITH DURATION OF DIABETES AND GLYCEMIC INDEX IN INDIVIDUALS WITH TYPE 1 AND 2 DIABETES MELLITUS.

Student's Journal of Health Research Africa, 2023
Background:  Kidney failure and nephropathy, defined as a dysfunctional kidney with a decline in ultrafiltration and a rise in blood urea and creatinine levels, are frequently caused by diabetes.
Prashant Kumar, Akhilesh Kumar, Rahul Raj   +2 more
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Structural Studies of a Urea Channel with Electron Microscopy [PDF]

, 2013
The Urea/Amide channel from Bacillus cereus (UACBc) was expressed in Escherichia coli with a C-terminal hexa-histidine tag. The protein was purified in detergent as confirmed by N-terminal sequencing.
Chan, Nathan
core  

Urea-induced unfolding of rRsbW.

, 2018
(A) The ellipticity values of rRsbW at 222 nm (θ222), were derived from their far-UV CD spectra (S1 Fig), normalized (Nor), and plotted versus the corresponding urea concentrations.
Subrata Sau (77536), Rajkrishna Mondal (2113678), Keya Sau (714765), Debabrata Sinha (5066888), Avisek Mahapa (714764), Rajagopal Chattopadhyaya (619014)   +5 more
core   +1 more source

El Corpus de Literatura Oral. Presentación del proyecto y avances de la investigación de campo en la Sierra de Segura

Boletín de Literatura Oral, 2016
Presentación del proyecto del Corpus de Literatura Oral con un análisis detenido de los avances ...
Marta UREA HERRADOR
doaj