Results 91 to 100 of about 220,644 (260)

Combating VEGFA‐siRNA‐Induced Metabolic Reprogramming via Glucose Utilization Deprivation

Advanced Science, EarlyView.
An ionizable lipid nanoparticle co‐delivers VEGFA siRNA and glucose oxidase to tumors to counteract VEGFA knockdown‐induced, glutamine‐driven metabolic compensation. Enzymatic glucose consumption reverses the adaptive pathways and restores metabolism toward baseline, thereby sensitizing tumors to therapy.
Lulu Zheng, Shuai Guo, Yingjixing Luo, Pengfei Wu, Haiyin Yang, Yingqiu Xie, Yuchuan Fan, Qing Liu, Bo Hu, Jia Huang, Yuanyu Huang   +10 more
wiley   +1 more source

Uric acid disrupts hypochlorous acid production and the bactericidal activity of HL-60 cells

Redox Biology, 2018
Uric acid is the end product of purine metabolism in humans and is an alternative physiological substrate for myeloperoxidase. Oxidation of uric acid by this enzyme generates uric acid free radical and urate hydroperoxide, a strong oxidant and ...
Larissa A.C. Carvalho, João P.P.B. Lopes, Gilberto H. Kaihami, Railmara P. Silva, Alexandre Bruni-Cardoso, Regina L. Baldini, Flavia C. Meotti   +6 more
doaj   +1 more source

Micromethods for determination of ammonia, urea, total nitrogen, uric acid, creatinine (and creatine), and allantoin [PDF]

, 1935
The success with which Krebs and Henseleit (1) employed Warburg’s method of surviving tissue slices in the problem of the formation of urea in the liver encouraged its use for a direct attack on other problems of nitrogen metabolism in ...
Borsook, Henry
core  

Neutrophil‐Driven Cascade‐Targeted Nanocarriers Restore Mitochondrial Homeostasis to Ameliorate Renal Ischemia–Reperfusion Injury

Advanced Science, EarlyView.
A neutrophil‐mediated dual‐targeting liposome (NKN‐LNP) is developed to treat renal ischemia–reperfusion injury. The system enables spatiotemporally controlled delivery of NMN to injured tubules via MMP‐2/9 activation and KIM1 recognition, restoring mitochondrial function through NAD+‐SIRT3 signaling and preventing the transition from acute kidney ...
Hangbin Ma, Yang Li, Shen Lin, Feifan Chu, Gaozhan Ren, Yinhui Mao, Mingzhi Wu, Yuning Ma, Qiwei Ji, Zujie Chen, Jinzhong Ji, Mingxin Sun, Yongpeng Xu, Xiaoli Sun, Longguang Tang, Hao Zhou   +15 more
wiley   +1 more source

NSUN5 Attenuates Renal Injury and Ferroptosis in Hyperuricaemic Nephropathy Through YBX2‐Dependent Stabilisation of SCD1 m5C Methylation

Advanced Science, EarlyView.
NSUN5 is downregulated in hyperuricaemic nephropathy. Overexpression of NSUN5 enhances the stability of SCD1 mRNA through the m5C reader YBX2, ultimately inhibiting ferroptosis in renal tubular epithelial cells. Additionally, this axis suppresses the NF‐κB signaling pathway to alleviate inflammation and upregulates ABCG2 to promote uric acid excretion,
Xiu‐xiu Song, Xiao‐guo Suo, Yue Yu, Kuo Zhang, Chen‐ao Li, Jie Wang, Hui‐xia Xu, Si‐yu Niu, Dong‐xue Lv, Zi‐hao He, Feng‐he Li, Xiao‐ming Meng, Juan Jin   +12 more
wiley   +1 more source

Effects of Marine Fish Oligopeptide Composite Preparation on Reducing Uric Acid and Repairing Kidney Damage

Shipin gongye ke-ji
Objective: To investigate the effects of marine fish oligopeptide composite preparation (MFOCP) on reducing uric acid and repairing kidney damage and the underlying mechanisms.
Zijia LU, Yu GAO, Yao XIE, Fengqin FENG
doaj   +1 more source

Correlation of serum uric acid and proteinuria in patients with type 2 diabetes mellitus [PDF]

, 2011
Background: Diabetes mellitus is one of the most common and important metabolic diseases worldwide. Hperuricemia is associated with kidney damage manifested by glomerular hypertrophy and sclerosis.
Mirhoseini, Mahmoud., Momeni, Ali., Niazi, Elahe.   +2 more
core  

Relation between serum uric acid and carotid intima-media thickness in healthy postmenopausal women [PDF]

, 2007
Serum uric acid (SUA) is associated with cardiovascular disease (CVD). However it is still disputed whether the relationship is mediated by other risk factors such as obesity, dyslipidaemia, hypertension and insulin resistance.
T. Montalcini, G. Gorgone, C. Gazzaruso, G. Sesti, F. Perticone, A. Pujia, J. Fang, A.D. Liese, F.N. Brand, B.F. Culleton, M. Burnier, E. Bonora, H. Vuorinen-Markkola, F. Facchini, A.Q. Galvan, D.H. O’Leary, M.L. Bots, Expert Panel on Detection, Evaluation,Treatment of High Blood Cholesterol in Adults, A. Pujia, A.D. Swijndregt van, W. Rathmann, J. Faller, C.S. Wingrove, A. Nicholls, M.H. Alderman, H. Kotake, A. Hoieggen, F. Leyva, G.N. Rao, P. Patetsios, A. Mazza   +30 more
core   +2 more sources

Multimodal Wearable Biosensing Meets Multidomain AI: A Pathway to Decentralized Healthcare

Advanced Science, EarlyView.
Multimodal biosensing meets multidomain AI. Wearable biosensors capture complementary biochemical and physiological signals, while cross‐device, population‐aware learning aligns noisy, heterogeneous streams. This Review distills key sensing modalities, fusion and calibration strategies, and privacy‐preserving deployment pathways that transform ...
Chenshu Liu, Haolin Fan, Minwoo Kim, Tong Zhou, Pinyi Yang, Lingdi Zhao, Yiran Wang, Ziyuan Che, Chia‐Wei Liu, Bingbing Li, Yangzhi Zhu   +10 more
wiley   +1 more source

Species Dependent Toxicity Comparison Outcome

Advanced Science, EarlyView.
By quantitatively assessing and comparing toxicity responses across different animal species and material compositions, our data reveal that toxicity rankings among different materials may be reversed across species. ABSTRACT Toxicity comparison plays a crucial role in material selection across diverse application fields.
Lian Xiao, Zhan Yu, Sihang Liu, Yuheng Liu, Chong Deng, Yugang Zhao, Yi Huang, Zhi‐Gang Zheng   +7 more
wiley   +1 more source