Results 191 to 200 of about 126,819 (310)

Small Cell Lung Cancer Establishes a Metabolic Autocrine Mechanism Through Active Extracellular ATP Transport

open access: yesCancer Science, EarlyView.
Small cell lung cancer (SCLC) actively exports ATP through PANX1 channels, triggering P2RX7‐mediated autocrine signaling and promoting tumor proliferation. Inhibition of PANX1 or P2RX7 disrupts this loop and suppresses tumor growth. ABSTRACT Small cell lung cancer (SCLC) is an aggressive malignancy with a 5‐year survival rate of less than 7%.
Takeshi Tsuruda   +2 more
wiley   +1 more source

Identification of Cumulative Assessment Groups of Pesticides [PDF]

open access: yes, 2012
Boberg, Julie   +8 more
core   +1 more source

Utility of Urinary Extracellular Vesicles for Colorectal Cancer: Comparison of DNA Quality and MRD Detection

open access: yesCancer Science, EarlyView.
Urinary EVs provide highly pure vesicles with superior DNA quality, making them a robust and completely non‐invasive source for molecular profiling. Urinary EV‐DNA–based MRD assessment shows significant prognostic value and may serve as a practical tool for postoperative monitoring and risk stratification in colorectal cancer.
Shintaro Kanaka   +14 more
wiley   +1 more source

Homozygous Loss‐of‐Function Variant in SLC20A1 Coding for Ubiquitous Phosphate Transporter PiT1 Is Associated With Multiple Developmental Abnormalities

open access: yesClinical Genetics, EarlyView.
Biallelic SLC20A1 loss‐of‐function variant causes a previously unrecognized multisystem developmental disorder. We report the first homozygous case presenting with tetralogy of Fallot, renal agenesis, polydactyly, and growth impairment. Transcriptome analysis of patient‐derived fibroblasts suggests significant dysregulation of pathways critical for ...
Eugénie Koumakis   +9 more
wiley   +1 more source

Use of MRI in the diagnosis of bladder cancer: a health economic analysis

open access: yes
BJU International, EarlyView.
Niranjan Sathianathen   +4 more
wiley   +1 more source

When Small Cells Matter: Diagnosing Bladder Small Cell Carcinoma on Urine Cytology

open access: yesCytopathology, EarlyView.
Small cell carcinoma of the bladder is rare, aggressive and diagnostically challenging on urine cytology. We report a case detected in urine and confirmed by cell block immunohistochemistry, highlighting the importance of careful assessment and limitations of the Paris System.
Haley Corbin   +3 more
wiley   +1 more source

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