Results 141 to 150 of about 1,127 (215)

Artificial Catch Bonds: From Molecular Design to Network Mechanics

ChemSystemsChem, Volume 8, Issue 5, September 2026.
Catch bonds strengthen rather than weaken under force. This review follows the discovery and development of our understanding of this counterintuitive phenomenon, from the molecular mechanisms that produce it to the design rules for engineering it in DNA, proteins, and polymers, and on to the collective network mechanics enabling materials that stiffen
Hengfeng Jiang, Micah Yang, Isaac T. S. Li   +2 more
wiley   +1 more source

Vigilant Algorithms and the Contagion of Risk in Automated Opioid Risk Assessment

Sociology of Health &Illness, Volume 48, Issue 7, September 2026.
ABSTRACT Amid the ongoing opioid crisis, U.S. health systems have extended prescription monitoring interfaces with proprietary reports that provide clinicians with algorithmic risk scores to guide opioid decisions. However, little is known about how such tools shape clinical encounters, professional authority and accountability in everyday care.
Amelie Lange, Benjamin Lipp
wiley   +1 more source

Patient‐reported outcomes for monitoring substance use treatment: A systematic review of single‐item measures

Addiction, Volume 121, Issue 9, Page 2292-2316, September 2026.
Abstract Background and aims Measurement‐based care (MBC) is a structured approach using standardized, repeated assessments to monitor treatment progress and guide clinical decision‐making. MBC improves outcomes for substance use treatment but can be time consuming due in part to lengthy assessment tools. Single‐item, patient‐reported outcome measures (
Thomas J. Reese, Hilary A. Tindle, Justin Bachmann, Adam Wright, Jessica S. Ancker, Carolyn M. Audet, Mauli V. Shah, Bryan D. Steitz, Michael H. Levin, Kristopher A. Kast, David Marcovitz, Amanda von Horn, A. Taylor Kelley, John F. P. Bridges   +13 more
wiley   +1 more source

Myths, Furphies and Red Herrings Associated With Dingo Ecology and Management

Ecological Management &Restoration, Volume 27, Issue 3, September 2026.
ABSTRACT Variability in the inferential strength or reliability of different scientific studies creates uncertainty in the status of knowledge on a given subject, giving rise to multiple myths, furphies and red herrings in scientific discourse. This is particularly true in the case of dingo ecology and management in Australia, which exemplifies common ...
Benjamin L. Allen
wiley   +1 more source

Actinomycin Derivatives: Structural Diversification and Biological Activities

ChemMedChem, Volume 21, Issue 15, 14 August 2026.
Actinomycins are chromopeptide antibiotics exhibiting remarkable structural diversity and broad bioactivity. This review traces their development from naturally occurring D‐, X‐, A‐, G‐, Y‐, and Z‐type analogs to precursor‐directed, synthetic, and semisynthetic derivatives.
Özge Can, Erdal Bedir
wiley   +1 more source

G6PC Downregulation Promotes Renal Calcium Oxalate Stone Formation via Lactate‐Induced SNAIL1 K206 Lactylation and Epithelial‐Mesenchymal Transition

Advanced Science, Volume 13, Issue 43, 3 August 2026.
In renal calcium oxalate stone formation, G6PC downregulation leads to lactate accumulation. This lactate mediates CBP/p300‐dependent lactylation of SNAIL1 at K206, promoting its nuclear translocation. Nuclear SNAIL1 activates the TGF‐β/SMAD3 pathway, driving epithelial‐mesenchymal transition and fibrosis, which ultimately facilitates crystal ...
Kai Liu, Boming Zhang, Ruixin Fan, Chen Duan, Yangjun Zhang, Huahui Wu, Xiangyang Yao, Xiongmin Mao, Bo Li, Youmiao Zeng, Zhenzhen Xu, Yang Wang, Mengcheng Luo, Xinyu Xu, Ninghan Feng, Heng Li, Hua Xu   +16 more
wiley   +1 more source

Diagnostic Challenges of Methanol Poisoning in Resource‐Limited Settings: A Case Series

Clinical Case Reports, Volume 14, Issue 8, August 2026.
ABSTRACT Methanol poisoning is a life‐threatening emergency, but diagnosis is challenging in resource‐limited settings lacking toxicology testing. This case series presents three cases of methanol poisoning: two patients with neurological symptoms and unexplained high anion gap metabolic acidosis were initially misdiagnosed as stroke or diabetic ...
Hongyun Chen, Liangbo Zeng, Baoliang Xiang, Ting Wu, Deju Li, Xianfeng Wu, Guanghua Pan   +6 more
wiley   +1 more source

Primary Large Cell Neuroendocrine Carcinoma of the Bladder Successfully Treated With Radical Cystectomy Alone: A Case Report

Clinical Case Reports, Volume 14, Issue 8, August 2026.
ABSTRACT Primary large‐cell neuroendocrine carcinoma of the bladder is highly invasive and has a poor prognosis. However, early curative treatment may lead to a good prognosis.
Shun Aoki, Takashi Kawahara, Yuri Nishino, Hideki Tsukada, Takayuki Hirano, Genta Iwamoto, Shusei Fusayasu, Jun‐ichi Teranishi, Kazuhide Makiyama, Hiroyuki Hayashi, Hiroji Uemura, Masatoshi Moriyama, Junichi Ohta   +12 more
wiley   +1 more source

Recurrent Idiopathic Intracranial Hypertension in a Patient With Systemic Lupus Erythematosus: A Case Report

Clinical Case Reports, Volume 14, Issue 8, August 2026.
ABSTRACT Idiopathic intracranial hypertension (IIH) is a rare but significant complication in patients with systemic lupus erythematosus (SLE). Its diagnosis and management can be challenging, particularly in cases of recurrence. We report the case of a 26‐year‐old Persian female with a history of SLE and hypertension who presented with persistent ...
Leila Poorsaadat, Baharak Tasorian, Mohammad Sadegh Fakhari, Reza Mohammadi   +3 more
wiley   +1 more source

Extensive Multicompartmental Air Dissection With Pneumoscrotum and Pneumorrhachis After Perineal Compressed‐Air Injury Without Demonstrable Persistent Full‐Thickness Rectal Perforation: A Case Report

Clinical Case Reports, Volume 14, Issue 8, August 2026.
ABSTRACT Anorectal barotrauma from compressed air is a rare but potentially life‐threatening injury, and most published cases involve frank colorectal perforation, whereas extensive extraluminal air dissemination without a demonstrable full‐thickness defect is poorly characterized. We report a previously healthy 21‐year‐old man who presented with acute
Van Trung Hoang, Vuong Hoang Trung Le, Vichit Chansomphou, The Huan Hoang   +3 more
wiley   +1 more source