Results 11 to 20 of about 10,481 (197)

Engineering Assembloids to Mimic Graft‐Host Skeletal Muscle Interaction

Advanced Healthcare Materials, EarlyView.
This study develops a graft‐host skeletal muscle assembloid model combining neuromuscular organoids with tissue‐engineered constructs. Pre‐seeding decellularized muscles with myogenic cells enhances cell migration and axon invasion from the organoid. The model exhibits regenerative capacity following acute damage, advancing the understanding of human ...
Lucia Rossi, Beatrice Auletta, Luigi Sartore, Marco La Placa, Giada Cecconi, Pietro Chiolerio, Edoardo Maghin, Silvia Angiolillo, Eugenia Carraro, Onelia Gagliano, Cecilia Laterza, Nicola Elvassore, Martina Piccoli, Anna Urciuolo   +13 more
wiley   +1 more source

Reoperative pouch surgery for suspected Crohn's‐related complications aided by biologic coverage: Early experience from an inflammatory bowel disease center

Annals of Gastroenterological Surgery, EarlyView.
This paper demonstrates that revisional/redo ileal pouch anal anastomosis (IPAA) surgery with concurrent biologic therapy provides a viable, stoma‐free alternative for patients with Crohn's disease‐like complications, showing a high functioning pouch rate and expanding options for managing pouch failure.
Mehmet Gulmez, Daniel J. Wong, Ariela K. Holmer, Eren Esen, Shannon Chang, Arman Erkan, David Hudesman, Andre da Luz Moreira, Feza H. Remzi   +8 more
wiley   +1 more source

Short‐ and Long‐Term Outcomes of Open, Laparoscopic, and Robot‐Assisted Surgery for Rectal Cancer

Annals of Gastroenterological Surgery, EarlyView.
Robot‐assisted rectal resection demonstrated superior short and long‐term outcomes compared to laparoscopic and open approaches. ABSTRACT Background Robot‐assisted surgery has short‐term benefits in rectal cancer surgery; however, its long‐term advantages remain unclear. This study compared short‐ and long‐term outcomes of open, laparoscopic, and robot‐
Marie Hanaoka, Hiroyasu Kagawa, Ataru Igarashi, Hiroshi Yoshihara, Shinichi Yamauchi, Masanori Tokunaga, Lin Peng‐Lin, Minkyung Shin, Yusuke Kinugasa   +8 more
wiley   +1 more source

Expert Strategies: Skull Base Reconstruction—Global Perspectives, Insights, and Algorithms through a Mixed Methods Approach

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Objective There is limited consensus on endoscopic skull base surgery (ESBS) reconstruction principles. This study aims to generate comprehensive themes regarding ESBS reconstruction by pooling the experiences of ESBS experts, with comparison to a literature review of current published evidence.
Edward C. Kuan, Vidit Talati, Jagatkumar A. Patel, Theodore V. Nguyen, Arash Abiri, Jonathan C. Pang, Khodayar Goshtasbi, Lauren Liu, John R. Craig, Peter Papagiannopoulos, Katie M. Phillips, Bobby A. Tajudeen, Nithin D. Adappa, James N. Palmer, Ahmad R. Sedaghat, Eric W. Wang, Vijay Anand, Pete S. Batra, Marvin Bergsneider, Manuel Bernal‐Sprekelsen, Benjamin S. Bleier, Paolo Cappabianca, Ricardo L. Carrau, Roy R. Casiano, Paolo Castelnuovo, Luigi M. Cavallo, Marc A. Cohen, Iacopo Dallan, Jean Anderson Eloy, Ivan H. El‐Sayed, James J. Evans, Juan C. Fernandez‐Miranda, Marco Ferrari, Sebastien Froelich, Paul A. Gardner, Christos Georgalas, Stacey T. Gray, Ehab Y. Hanna, Richard J. Harvey, Sang Duk Hong, Peter H. Hwang, Daniel F. Kelly, Doo‐Sik Kong, Ming‐Ying Lan, John Y. K. Lee, Corinna G. Levine, James K. Liu, Davide Locatelli, Cem Meço, Erin L. McKean, Piero Nicolai, Gurston G. Nyquist, Kazuhiro Omura, Thibault Passeri, Zara M. Patel, Maria Peris Celda, Carlos Pinheiro Neto, Danny M. Prevedello, Mindy R. Rabinowitz, Shaan M. Raza, Pablo F. Recinos, Marc R. Rosen, Zoukaa B. Sargi, Rodney J. Schlosser, Theodore H. Schwartz, Raj Sindwani, Carl H. Snyderman, Aldo C. Stamm, Brian D. Thorp, Mario Turri‐Zanoni, Marilene B. Wang, Wei‐Hsin Wang, Ian J. Witterick, Tae‐Bin Won, Bradford A. Woodworth, Peter‐John Wormald, Gabriel Zada, Shirley Y. Su   +77 more
wiley   +1 more source

Label‐Free Microscale Technologies for Isolation of Heterogeneous Circulating Tumor Cells

Advanced NanoBiomed Research, EarlyView.
The isolation of circulating tumor cells (CTCs) from liquid biopsy samples is crucial for cancer treatment and monitoring. This review evaluates primary label‐free isolation methods for capturing heterogeneous CTCs and examines their potential to provide deeper insights into tumor heterogeneity and dynamics of cancer progression.
Gürhan Özkayar, Esma Derin, Georg R. Pesch, John W. M. Martens, Peter ten Dijke, Pouyan E. Boukany   +5 more
wiley   +1 more source

Absolute Oral Bioavailability and Bioequivalence of LSD Base and Tartrate in a Double‐Blind, Placebo‐Controlled, Crossover Study

Clinical Pharmacology &Therapeutics, EarlyView.
Lysergic acid diethylamide (LSD) is currently being investigated as a potential treatment for psychiatric and neurological disorders. Different LSD formulations (base or tartrate, oral or intravenous) are being used. Unclear is whether LSD base and tartrate pharmacokinetics are equivalent.
Denis Arikci, Friederike Holze, Lorenz Mueller, Patrick Vizeli, Deborah Rudin, Dino Luethi, Cedric M. Hysek, Matthias E. Liechti   +7 more
wiley   +1 more source

Changing trends in anabolic‐androgenic steroid use within Scottish prisons: Detection, prevalence, and quantitation

Drug Testing and Analysis, EarlyView.
This study reports the qualitative and quantitative detection of anabolic‐androgenic steroids (AASs) in seized samples from prisons. Since 2022 there has been an increase in AAS detections with oxymetholone the most prevalent AAS, followed by metandienone, methyltestosterone, and oxandrolone.
Caitlyn Norman, Richard L. Harries, Robert Reid, Lorna A. Nisbet, Niamh Nic Daéid   +4 more
wiley   +1 more source

Rapid Analytical Method for Quantification of Gamma‐Hydroxybutyrate (GHB) in Hair by UPLC‐MS/MS

Drug Testing and Analysis, EarlyView.
A rapid and simple UPLC‐MS/MS method for quantification of GHB in 10 mg of hair was developed. The method was satisfactorily validated, showing a linear range of 0.5–50 ng/mg, which allows us to quantify endogenous and exogenous GHB concentrations.
Miriam Blanco‐Ces, Ana de‐Castro‐Rios, Angela Lopez‐Rabuñal, Maria Cobo‐Golpe, Angelines Cruz, Elena Lendoiro   +5 more
wiley   +1 more source

Associations Between Self‐Reported Cocaine Use Patterns and Cocaine and Its Metabolites in Hair: Implications for Clinical and Forensic Practices

Drug Testing and Analysis, EarlyView.
This study demonstrates that concentrations of cocaine and its main metabolites in hair reliably predict an individual's actual intensity of cocaine use and effectively differentiate between dependent and non‐dependent users. ABSTRACT In forensic toxicology, it has been debated if hair testing allows an estimation of the intensity of cocaine use—an ...
Simon Grison, Lydia Johnson‐Ferguson, Matthias Vonmoos, Markus R. Baumgartner, Boris B. Quednow   +4 more
wiley   +1 more source

Trends in the Detection of Erythropoietin Receptor Agonists (ERAs) in Anti‐Doping: An Analysis of Recent Adverse Analytical Findings (AAFs)

Drug Testing and Analysis, EarlyView.
Trends in adverse analytical findings (AAFs) for erythropoietin Receptor Agonist (ERAs) we examined to assess the impact of ERA testing and detection on athlete behavior. It was observed that the largest fraction of ERA AAFs occurs on the first sample ever taken from an athlete (43.2%), and that the ERA AAFs rates decline steadily as athletes continue ...
Tristan Equey, Julian Broséus, Norbert Baume, Reid Aikin   +3 more
wiley   +1 more source