Results 31 to 40 of about 205,138 (303)

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Patient and community nurse perspectives on recruitment to a randomized controlled trial of urinary catheter washout solutions [PDF]

, 2019
Aims To provide evidence around the acceptability of a proposed randomised controlled trial (RCT) of catheter washout solutions. Design: A sample of senior community nursing staff (n=7) were interviewed and four focus groups with a sample of community
Hagen, Suzanne, Mackay, William G, Shepherd, Ashley, Steel, Emma, Taylor, Anne   +4 more
core   +4 more sources

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

The clinical effectiveness of transurethral incision of the prostate : a systematic review of randomised controlled trials [PDF]

, 2011
The original publication is available at www.springerlink.com.Peer ...
AP Verhagen, AV Sarma, BH Zorn, Cynthia Fraser, Graeme MacLennan, H Hedlund, HO Nielsen, James N’Dow, L Saporta, M Emberton, M Riehmann, M Rodrigo Aliaga, M Tkocz, Matthew Shaw, MK Li, MM Christensen, P Boyle, P Hellstrom, PF Soonawalla, PH Abrams, Q Yang, RF Talic, Robert Pickard, S Downs, S Furuya, S Jahnson, T Dorflinger, T Lourenco, Tania Lourenco, V Watson   +29 more
core   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

MANAJEMEN RETENSI URIN PADA LANSIA DI IGD: STUDI KASUS DARI RS PKU MUHAMMADIYAH GAMPING

JPK
Urinary Retention is a condition of inability to urinate even though the bladder is full and this condition is often accompanied by a sensation of pain.
Meisty Anggraeni Meisty, Efi Fibriyanti
doaj   +1 more source

Inguinal Herniation of the Urinary Bladder Presenting as Recurrent Urinary Retention

Case Reports in Surgery, 2015
Herniation of the urinary bladder into the inguinal canal is an uncommon finding, observed in 0.5–4% of inguinal hernias (Curry (2000)). It is usually associated with other conditions that increase intra-abdominal pressure such as bladder neck ...
Amit Frenkel, Aviel Roy-Shapira, Ilan Shelef, Gadi Shaked, Evgeni Brotfain, Leonid Koyfman, Abraham Borer, Moti Klein   +7 more
doaj   +1 more source

Low zinc status and absorption exist in infants with jejunostomies or ileostomies which persists after intestinal repair. [PDF]

, 2012
There is very little data regarding trace mineral nutrition in infants with small intestinal ostomies. Here we evaluated 14 infants with jejunal or ileal ostomies to measure their zinc absorption and retention and biochemical zinc and copper status. Zinc
Abrams, Steven A, Balay, Kimberly S, Chen, Zhensheng, Griffin, Ian J, Hawthorne, Keli M, Hicks, Penni D   +5 more
core   +4 more sources

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source