Results 111 to 120 of about 41,306 (333)

Metabolic dynamics of human external urethral sphincter myoblast differentiation and the effects of tricarboxylic acid cycle inhibition

Scientific Reports
Stress urinary incontinence commonly arises with aging or following prostatectomy, yet its underlying mechanisms remain unclear. To address this, we investigated the role of metabolic pathways—particularly the tricarboxylic acid (TCA) cycle—in the ...
Hironori Kai, Shinro Hata, Noriko Hamamatsu, Mayuka Shinohara, Keiko Matsuura, Hiromitsu Mimata, Toshitaka Shin   +6 more
doaj   +1 more source

The history of prosthetic devices for postprostatectomy incontinence

Continence Reports
Urinary incontinence has been studied since the Egyptian era of the second millennium BCE. Throughout history, several devices have been developed to address this condition.
Juliusz J. Szczesniewski, David E. Díaz, Miguel Virseda-Chamorro, Giordano Polisini, Enrico Ammirati, Alessandro Giammò   +5 more
doaj   +1 more source

Association of bi‐parametric MRI measures with continence after robot‐assisted radical prostatectomy

BJU International, Volume 135, Issue 4, Page 603-610, April 2025.
Objective To investigate the association between pre‐ and postoperative magnetic resonance imaging (MRI) measurements of the membranous urethra and the prostate volume and continence following robot‐assisted radical prostatectomy (RARP). Patients and Methods From December 2018 to June 2022, 100 continent patients undergoing unilateral nerve‐sparing or ...
Alexander B. Nolsøe, Vibeke Løgager, Lars Boesen, Peter Busch Østergren, Henrik Jakobsen, Christian Fuglesang S. Jensen, Niels Henrik Bruun, Jens Sønksen, Mikkel Fode   +8 more
wiley   +1 more source

Focal therapy using a novel cooled laser device for prostate cancer: early trial results

BJU International, EarlyView.
Objectives To determine the short‐term oncological results and safety of the ProFocal Laser Therapy for Prostate Tissue Ablation (PFLT‐PC) trial, the first phase II clinical trial of ProFocal® (Medlogical Innovations, Sydney, Australia), a novel, cooled laser focal therapy (cLFT) device for prostate cancer (PCa) treatment. Patients and Methods Men with
Jonathan Kam, Bishoy Hanna, Stuart Jackson, Stephen McCombie, George McClintock, Matthew J. Roberts, Jake Rahkala, Jeremy Teoh, Mohan Arianayagam, Bertram Canagasingham, Ahmed Saeed Goolam, Nicola Jeffery, Matthew Winter, Mohamed Khadra, Raymond Ko, Nicholas Mehan, Isaac Thangasamy, Celi Varol   +17 more
wiley   +1 more source

Operative complications and results of the "SPARC" procedure for stress urinary incontinence [Operativne komplikacije i ishod metode SPARC u liječenju statičke inkontinencije mokraće] [PDF]

, 2009
The aim of this study was to determine the efficacy and operative complications of the suprapubic arc (SPARC) procedure in stress incontinent women with and without previous anti-incontinence surgery.
Babić, Ivan, Gojević, Ante, Gregov, Marija, Kalafatić, Držislav, Lovrić Gršić, Helena, Orešković, Slavko   +5 more
core  

Long‐term patient‐reported outcomes of open urorectal fistula repair after prostate cancer treatment

BJU International, EarlyView.
Objectives To evaluate long‐term outcomes of open urorectal fistula (URF) repair, including URF recurrence, need for re‐intervention, and patient‐reported outcomes. Patients and Methods This retrospective study included men undergoing open URF repair between 2014 and 2024.
Max C. Wagner, Jakob Klemm, Navid Roessler, Robert J. Schulz, Dejan K. Filipas, Margit Fisch, Roland Dahlem, Malte W. Vetterlein   +7 more
wiley   +1 more source

Artificial sphincter “BR - SL - AS 904” in the treatment of urinary incontinence after radical prostatectomy: efficacy, practicality and safety in a prospective and multicenter study

International Brazilian Journal of Urology
Purpose: The objective of the present study is to test the efficiency and practicality of a new artificial sphincter “BR - SL - AS – 904” in the control of urinary incontinence in post - PR patients and to evaluate their complications.
Salvador Vilar Correia Lima, Evandilson Guenes Campos de Barros, Fabio de Oliveira Vilar, Flavia Cristina Morone Pinto, Thomé Décio Pinheiro Barros, José Carlos Truzzi, Luiz Gustavo M. de Toledo, Francisco Kanasiro, João Luiz Amaro   +8 more
doaj   +1 more source

Novel therapeutic targets for chronic visceral pain in gastrointestinal disorders

British Journal of Pharmacology, EarlyView.
Chronic visceral pain imposes a major clinical challenge in gastroenterology and beyond, profoundly impacting patients' quality of life. However, limited understanding of its complex, multifaceted pathophysiology, encompassing both peripheral and central mechanisms, continues to impede the development of effective management strategies.
Fleur Veldman, Christopher J. Black, Andrea Shin, Daniel Keszthelyi   +3 more
wiley   +1 more source

The Outcome of Cell Therapy Treating Urinary Incontinence Correlates with Precise Cell Localization in the Sphincter Complex

Biomedicines
Background/Objectives: Urethral sphincter muscle deficiency is the leading cause of stress urinary incontinence. Preclinical and clinical studies suggested that cell therapy may improve the situation.
Niklas Harland, Liv Johnen, Kamal T. Avula, Andrea Buzanich-Ladinig, Lukas Schwarz, Jasmin Knoll, Arnulf Stenzl, Wilhelm K. Aicher   +7 more
doaj   +1 more source

The Diagnostic Odyssey of a Biochemically Confirmed Case of ML II: The First Western Patient With LYSET Deficiency

Clinical Genetics, EarlyView.
We identify a female patient with a homozygous nonsense variant (p.Gln38Ter) in the LYSET gene. This is the first western report of a challenging case of an extensive diagnostic odyssey and demonstrates that the LYSET gene must be considered in the differential diagnosis when M6P‐labeled lysosomal enzymes are altered.
Fernanda Sperb‐Ludwig, Taciane Alegra, Leonardo Martinello da Rosa, Nataniel Floriano Ludwig, Renata Voltolini Velho, Ida Vanessa Doederlein Schwartz   +5 more
wiley   +1 more source