Results 91 to 100 of about 18,013,337 (254)

Nuclear Pore Mechanotransduction in Oncology: A Structural Axis of Vulnerability for Targeted Intervention

Advanced Materials, EarlyView.
Cancer‐associated NPC remodeling creates a high‐flux, low‐stringency nuclear state that supports malignant adaptation but increases mechanical fragility. Targeting the FG‐barrier or NPC scaffold may drive mechanostat failure, envelope rupture, DNA damage, and loss of nuclear integrity.
Sílvio Terra Stefanello, Caren Rigon Mizdal, Aline Franzen da Silva, Yun Qian, Wei‐En Yuan, Victor Shahin   +5 more
wiley   +1 more source

Inflammation Unchecked: Concurrent Kawasaki Disease and Stevens‐Johnson Syndrome in an 18‐Month‐Old Child

Arthritis Care &Research, EarlyView.
Catherine Deffendall, Jodi Backalar, Elizabeth Acevedo Zapata, Adriana Della Porta, Lorin Bibb, Tyler Reese, Charlotte M. Brown   +6 more
wiley   +1 more source

Lab‐in‐a‐Tube System Integrating Hierarchically Wrinkled Electrodes and DNAzyme‐Functionalized Beads for Diagnosis of Clostridioides difficile Infection

Advanced Materials, EarlyView.
The point‐of‐care diagnosis of Clostridioides difficile infection remains challenging due to reliance on slow culture and amplification‐based methods. A lab‐in‐a‐tube electrochemical biosensor integrating DNAzymes, antifouling magnetic beads, and a hierarchically structured flow cell enables amplification‐ and culture‐free detection directly in stool ...
Survanshu Saxena, Soyeon Lee, Youngeun Choi, Jonathan L'Heureux‐Hache, Jiaying Liu, Sadman Sakib, Sara M. Imani, Marek Smieja, Yingfu Li, Todd Hoare, Leyla Soleymani   +10 more
wiley   +1 more source

A novel sono-activatable nanoreactor induces precision intratumoral juglone generation and caspase 3/GSDME-mediated pyroptosis for treatment of bladder cancer

Journal of Nanobiotechnology
Background Juglone, a natural naphthoquinone compound, exhibits potent anticancer activity but faces clinical limitations due to poor solubility, low bioavailability, and systemic toxicity.
Yuanfeng Zhang , Enguang Yang, Xinyu Zhang , Yibo Shi , Guangrui Fan, Yuhan Wang, Junqiang Tian, Hanzhang Wang, Zhilong Dong, Yingru Wang, Liang Cheng, Zhiwen Zhao, Yonghai Zhang, Baodui Wang, Zhiping Wang   +14 more
doaj   +1 more source

AGBL2 promotes renal cell carcinoma cells proliferation and migration via α-tubulin detyrosination

Heliyon
Background: AGBL2's role in tumorigenesis and cancer progression has been reported in several cancer studies, and it is closely associated with α-tubulin detyrosination.
Wei Liu, Yifei Zhang, Yechen Nie, Yifu Liu, Zhongqi Li, Zhicheng Zhang, Binbin Gong, Ming Ma   +7 more
doaj   +1 more source

The relationship between infecting organisms and underlying structural anomalies in children with urinary tract infections [PDF]

, 2008
Introduction: Urinary tract infections (UTIs) are a common cause of morbidity in childhood with potential for renal scarring and reflux nephropathy which can lead to hypertension and end-stage renal failure.
Said Conti, Valerie, Torpiano, John G., Grech, Victor E., Vella, Cecil   +3 more
core  

Recent Advances in Light‐Addressable Electrochemistry for Spatially Resolved Applications

Advanced Materials Technologies, EarlyView.
This comprehensive review highlights light‐addressable electrochemistry as a powerful tool that uses light to control localized chemical reactions on unstructured semiconductor surfaces. The work evaluates advanced strategies to optimize electrode materials for enhanced spatial resolution and stability. Furthermore, it showcases diverse applications in
Nhi Trang Vo, Sina Jamali, Nam‐Trung Nguyen   +2 more
wiley   +1 more source

Anoikis-related genes predicts prognosis and therapeutic response in renal cell carcinoma

Annals of Medicine
Background Metastasis represents the primary cause of cancer-related mortality, with a high incidence observed in renal cell carcinoma (RCC). Anoikis, a specialized form of apoptosis, plays a crucial role in preventing displaced cells from adhering to ...
Lizhi Zhou, Hengcheng Lu, Bin Fu, Jianhan Fu   +3 more
doaj   +1 more source

Magnetic Micro‐ and Nanorobots for Precision Thrombolysis: Design Strategies and Translational Challenges

Advanced Robotics Research, EarlyView.
Micro‐ and nanorobots for targeted thrombolysis. This perspective elaborates on the clinical indication of blood clot disorders and current limitations for treatment. As a novel, alternative solution, micro‐ and nanorobots can be used to treat and break down thrombi.
Joshua M. Mesfin, Yimo Yan, Nikola Cesarovic, Simone Schuerle   +3 more
wiley   +1 more source

A database of naturally occurring human urinary peptides and proteins for use in clinical applications [PDF]

, 2007
Owing to its availability, ease of collection and correlation with (patho-) physiology, urine is an attractive source for clinical proteomics. However, the lack of comparable datasets from large cohorts has greatly hindered development in this field ...
Christian Neusüss, Jens-Uwe Stolzenburg, Lise Tarnow, Danilo Fliser, Stephane Decramer, Arnold Ganser, Joshua Coon, Eva Weissinger, Visith Thongboonkerd, Jochen Ehrich, Karlheinz Peter, Raymond Vanholder, Jan Novak, Harald Rupprecht, Moritz Frommberger, Andrzej Krolewski, Petra Zürbig, Bruce Julian, David Good, Hartwig Bauer, Ziad Massy, Anna Dominiczak, Walter Kolch, Eric Schiffer, Dan Theodorescu, Kasper Rossing, Mario Luppi, Stefan Herget-Rosenthal, Wilfried Gwinner, Holger Jahn, Mark Giolami, Volker Kliem, Harald Mischak, Markus Kellmann, Mohammed Dakna, Michael Melter, George Jerums, Joost Schanstra, Philippe Schmitt-Kopplin, Marion Haubitz, Igor Golovko, Georg Behrens   +41 more
core