Results 161 to 170 of about 368,977 (261)

Trypstatin as a Novel TMPRSS2 Inhibitor with Broad‐Spectrum Efficacy against Corona and Influenza Viruses

open access: yesAdvanced Science, EarlyView.
Trypstatin, a 61‐amino acid Kunitz‐type protease inhibitor derived from human Bikunin, potently inhibits TMPRSS2 and related proteases. It blocks spike‐ and hemagglutinin‐mediated entry of multiple respiratory viruses in vitro reduces SARS‐CoV‐2 replication in human airway cultures, and lowers viral load and symptoms in infected hamsters, demonstrating
Jan Lawrenz   +24 more
wiley   +1 more source

Association of Elevated Urinary Concentration of Renin-Angiotensin System Components and Severe AKI [PDF]

open access: bronze, 2013
Joseph L. Alge   +7 more
openalex   +1 more source

Frontiers in Nondrug Treatment of Sarcopenia: A Review of Pathological Mechanisms and the Latest Treatment Strategies

open access: yesAGING MEDICINE, EarlyView.
This article mainly introduces the pathologic process of sarcopenia and the recent progress in diagnosis and treatment, especially the nondrug treatment. ABSTRACT Sarcopenia refers to the progressive decline and wasting of skeletal muscle function, typically linked to aging or as a secondary effect of various conditions, including systemic inflammation,
Qi‐Fei Kuang   +2 more
wiley   +1 more source

Optimal duration of antimicrobial prophylaxis in patients undergoing distal pancreatectomy: A multicenter cohort study

open access: yesAnnals of Gastroenterological Surgery, EarlyView.
Prolonged administration of antimicrobial prophylaxis might not be effective to prevent surgical site infections after distal pancreatectomy compared to intraoperative or up to 24‐h administration. Abstract Background Antimicrobial prophylaxis is routinely administered in patients undergoing distal pancreatectomy, with cephalosporins being the most ...
Kenjiro Okada   +8 more
wiley   +1 more source

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