Results 161 to 170 of about 18,013,337 (254)

OAF Blocks SIAH1‐Mediated Degradation of SCPX, a Therapeutic Strategy for MASLD

Advanced Science, EarlyView.
This study shows OAF directly binds to SCPX and inhibits its interaction with the E3 ligase SIAH1, thereby protecting SCPX from ubiquitin‐dependent degradation and stabilizing its levels. This OAF‐SCPX axis represents a novel pathway in lipid homeostasis, highlighting OAF as a promising therapeutic candidate for MASLD.
Zongxi Li, Jingyue Song, Kaili Ma, Shunan Tang, Shuqian Wang, Wenya Ji, Chen Lu, Ting Zhang, Huaping Zheng, Xiaowei Zheng, Shanshan Lai, Cheng Deng   +11 more
wiley   +1 more source

Modified ureteral stent drainage technique for management of enteric fistula following Mainz II procedure and radical Cystectomy: Two case reports

Asian Journal of Surgery
Wei Yang, Qiqi He, Xiaoran Li, Junsheng Bao   +3 more
doaj   +1 more source

Research progress on treating urinary system stones using ureteroscopy combined With a negative-pressure suction sheath. [PDF]

Front Surg
Liang J, Xiao H, Yu S.
europepmc   +1 more source

Editorial: The innate and adaptive immune system in human urinary system. [PDF]

Front Immunol, 2023
Behzadi P, Kim CH, Pawlak EA, Algammal A.   +3 more
europepmc   +1 more source

Natural Product Toosendanin Suppresses the Malignant Development of Skin Melanoma by Targeting BNC2 for Degradation

Advanced Science, EarlyView.
BNC2 exhibits context‐dependent opposing functions across multiple cancer types. This study reveals BNC2 as an oncogenic driver of melanoma proliferation and metastasis through transcriptional activation of PIK3CA. The natural compound TSN simultaneously degrades BNC2 and its oncogenic partner SMAD3 via CRBN‐dependent ubiquitination.
Hui Dai, Xin Mei Zhang, Jing Cheng Zhang, Xu Ting Deng, Qiao Liu, Mustafa Hussein Ali, Fang Zhou Yin, Wu Yin   +7 more
wiley   +1 more source

Publisher Correction: Unraveling the role of gut microbiota by fecal microbiota transplantation in rat model of kidney stone disease

Scientific Reports
Sittiphong Hunthai, Manint Usawachintachit, Mana Taweevisit, Monpichar Srisa-Art, Weerapat Anegkamol, Piyaratana Tosukhowong, Pakkapon Rattanachaisit, Natthaya Chuaypen, Thasinas Dissayabutra   +8 more
doaj   +1 more source

Response to Letter to the Editor on: "No Cystometrogram Among Veterans With Spinal Cord Injury Results in Adverse Urinary System Outcomes," by N. Yıldız and S. Ötken. [PDF]

Neurourol Urodyn
Lavelle J, Hornberger J.
europepmc   +1 more source

AARS1‐Mediated H3K27 Lactylation Rewires Glycolysis to Sustain Aggressive and Recurrent Bladder Cancer

Advanced Science, EarlyView.
AARS1 drives PI3K–AKT–mTOR‐dependent glycolysis in bladder cancer, promoting lactate accumulation, increased lactylation, H3K27la enrichment at the HK2 promoter, and HK2 transcription. HK2 reinforces glycolysis, sustaining a metabolic–epigenetic program associated with tumor progression, recurrence, and metastasis.
Qin Yuan, Tianbao Song, Yipeng He, Sihan Xia, Yaoqiu Huang, Wenlin He, Qin Yi, Zefeng Wang, Peihan Wang, Chenbo Huang, Linzhi Li, Zhen Yin, Fan Cheng, Weimin Yu   +13 more
wiley   +1 more source

No Cystometrogram Among Veterans With Spinal Cord Injury Results in Adverse Urinary System Outcomes. [PDF]

Neurourol Urodyn
Lavelle J, Hornberger J.
europepmc   +1 more source

Tumor Exposomics: A New Paradigm for Individualized Continuous Exposure Monitoring

Advanced Science, EarlyView.
Tumor exposomics integrates continuous monitoring of environmental exposures, endogenous biological responses, and behavioral factors within a unified temporal framework. By combining multimodal sensing technologies with AI‐enabled causal modeling, this emerging paradigm reconstructs exposure‐damage trajectories and supports individualized dynamic risk
Kaicheng Shen, Weiyi Wang, Yang Wang, Yiqiang Wu, Xiaohong Liu, Wei Zhang, Juanjuan Ou   +6 more
wiley   +1 more source