Results 261 to 270 of about 23,859,193 (367)

TREM2 Drives Neutrophil Extracellular Traps‐Induced Dendritic Cell Maturation and Contributes to Lupus Progression

Advanced Science, EarlyView.
TREM2 recognizes NETs‐derived MPO to promote DC maturation and antigen presentation, thereby exacerbating the autoimmune response in SLE. Mechanistically, TREM2 activation triggers the DAP12/SYK/ERK cascade and enhances NETs internalization by DCs, which in turn activates the cGAS/STING signaling pathway.
Jingxian Shu, Jiabi Liang, Linda Zeng, Shuping Zhong, Xueling Fang, Yating Xu, Yongjian Wu, Xi Huang   +7 more
wiley   +1 more source

Role of DNA methylation transferase in urinary system diseases: From basic to clinical perspectives (Review). [PDF]

Int J Mol Med
Yang Y, Wang Y, Fan X, Xu X, Wang H, Wang X, Shi T, Tang J, Guan Y, Li S, Wang A.   +10 more
europepmc   +1 more source

Stress‐Induced Activation of Prolactin‐NR4A1‐Midkine Axis Exacerbates Skin Inflammation

Advanced Science, EarlyView.
Chronic psychological stress activates prolactin signaling to reprogram dermal fibroblasts into APCDD1+ inflammatory effectors via NR4A1, driving midkine secretion. This paracrine hub amplifies keratinocyte proliferation and immune recruitment, thus exacerbating skin inflammation.
Zhiguo Li, Huiyi Quan, Wanting Liu, Jiaoling Chen, Mengyang Chu, Xin Tang, Ke Xue, Xuan Liu, Jingyi Ma, Yaxing Bai, Ruina Dong, Bing Li, Junfeng Hao, Wei Guo, Qingyang Li, Erle Dang, Johann E Gudjonsson, Gang Wang, Shuai Shao   +18 more
wiley   +1 more source

Progress and application of intelligent nanomedicine in urinary system tumors. [PDF]

J Pharm Anal
Xiao Y, Zhong L, Liu J, Chen L, Wu Y, Li G.   +5 more
europepmc   +1 more source

Application of the first rechargeable sacral neuromodulation system for treatment of neurogenic lower urinary tract dysfunction in China: a case report.

, 2023
Xinhao Wang, Jiawen Wang, Wei Zhang, Xiaodong Liu, Ze-Hao Yan, Lingfeng Meng, Yaoguang Zhang   +6 more
openalex   +1 more source

The Geometry of Layer 2/3 Cortical Sound Processing in Slow Wave Sleep

Advanced Science, EarlyView.
Sleep is associated with a sensory disconnection whose mechanisms remain elusive. Large neuronal population recordings in the auditory cortex revealed that, in NREM sleep, the neural code for sounds is highly similar to wakefulness, but coordinated modulations of neuron responsiveness intermittently disconnect the local cortical networks from sensory ...
Allan Muller, Anton Filipchuk, Sophie Bagur, Brice Bathellier   +3 more
wiley   +1 more source

Same-Session Bilateral Retrograde Intrarenal Surgery for Upper Urinary System Stones: Safety and Efficacy

Journal of endourology, 2014
E. Alkan, E. Avcı, A. O. Ozkanli, O. Acar, M. Balbay   +4 more
semanticscholar   +1 more source

Burn‐Safe Biodegradable Magnetocaloric Composites for Temperature‐Controlled Biomedical Applications

Advanced Science, EarlyView.
This work investigates a magnetocaloric (Mn,Fe)2(P,Si) compound tailored for precise, self‐regulating heating in biomedical use. With a Curie temperature tuned at 43 °C, it enables therapeutic activation without overheating. Encapsulation in a composite ensures controlled temperature rise under an alternating magnetic field (AMF), with high ...
Pornpawee Uliss, Wuliji Hanggai, Friso Kahler, Elena Aprea, Qi Jia, Vasiliki Gkouzioti, Jean‐Philippe Frimat, Ekkes Brück, Clementine M. Boutry   +8 more
wiley   +1 more source

A Novel FGFR3‐Targeting Antibody‐Drug Conjugate Induces Tumor Cell Apoptosis through the cGAS–STING Pathway in Bladder Cancer

Advanced Science, EarlyView.
LZU‐WZLYCS01 is a novel FGFR3‐targeting ADC for bladder cancer with 7‐ethyl‐9‐fluorocamptothecin (A2) as its cytotoxic payload. LZU‐WZLYCS01 intracellularly releases A2, which targets MAD2L1 to activate the cGAS‐STING pathway and induce tumor cell apoptosis.
Shu Cui, Xiongfei Luo, Guangrui Fan, Jingqi Jiang, Yingru Wang, Enguang Yang, Jinpeng Ma, Ze Zhang, Yuhan Wang, Juan Wang, Dengtuo Wang, Hanzhang Wang, Liang Cheng, Junqiang Tian, Zhilong Dong, Yingqian Liu, Zhiping Wang   +16 more
wiley   +1 more source

Urinary System Diseases Diagnosis Using Machine Learning Techniques

, 2015
S. Medjahed, T. A. Saadi, A. Benyettou
semanticscholar   +1 more source