Results 181 to 190 of about 752,211 (305)

Assessment of Pharmacokinetic Drug Interaction of Asciminib with Atorvastatin in Healthy Participants

Clinical Pharmacology in Drug Development, EarlyView.
Abstract Asciminib is the first BCR::ABL1 inhibitor that Specifically Targets the ABL Myristoyl Pocket (STAMP) in patients with chronic myeloid leukemia. This phase 1, two‐treatment‐period, drug‐drug interaction study evaluated the effect of steady‐state asciminib on the pharmacokinetics of atorvastatin.
Matthias Hoch, Wendy Weis, Felix Huth, Seshulatha Jamalapuram, Michelle Quinlan, Amarnath Bandaru, Suleyman Eralp Bellibas, Asmae Mirkou, Shruti Kapoor, Shefali Kakar   +9 more
wiley   +1 more source

Descriptive Epidemiology of <i>Klebsiella</i> spp. Urinary Tract Infections in Central Africa. [PDF]

Biomed Res Int
Mayombo Ngoussou E, Mounioko F, Mundunge M, Mabika Mabika R, Zong Minko O, Ondjiangui LF, Yala JF.   +6 more
europepmc   +1 more source

Effects of High‐ and Low‐Fat Meals on the Bioavailability and Pharmacokinetics of Votoplam, a HTT Gene Splicing Modifier

Clinical Pharmacology in Drug Development, EarlyView.
Abstract Votoplam is a novel, orally bioavailable, small molecule HTT gene splicing modifier that is being developed for the treatment of Huntington's disease. This was a single dose, open‐label, two‐period, crossover food effect study that evaluated the effect of high‐ and low‐fat meals on 20 mg votoplam in healthy participants. There was a washout of
Lucy Lee, Amy‐Lee Richards, Nageswara Reddy, Brian Beers, Lee Golden, Ronald Kong   +5 more
wiley   +1 more source

Lower urinary tract symptoms are beyond lower urinary tract

Gynecology and Minimally Invasive Therapy, 2015
Ming-Ping Wu
doaj   +1 more source

Mechanisms of prostatic inflammation-mediated male lower urinary tract symptoms. [PDF]

Am J Clin Exp Urol
Scharpf BR, Vezina CM.
europepmc   +1 more source

Patient-related risk factors for urinary retention following ambulatory general surgery: Asystematic review and meta-analysis [PDF]

, 2015
Mason, SE, Mayer, E, Purkayastha, S, Scott, AJ   +3 more
core   +1 more source

Biomarkers of Drug‐Induced Kidney Injury: Use in Clinical Trials and Recent Examples of Impact on Drug Development

Clinical Pharmacology &Therapeutics, EarlyView.
This manuscript describes the scope of implementation and impact of a regulatory agency‐qualified panel of six urine biomarkers on drug development, the process for which was conducted and funded by the Critical Path Institute, the Foundation for the National Institutes of Health, and the United States Food and Drug Administration.
Tanja S. Zabka, Michael Lawton, Tom Chu, Gary S. Friedman, Katrina Peron, Stefan R. Sultana, Warren E. Glaab, Nicholas M. P. King   +7 more
wiley   +1 more source

Associations of pain in young men presenting with lower urinary tract symptoms. [PDF]

Indian J Urol
Sinha S, Trivedi S, Mittal A, Bora GS, Nayyar R, Vasudeva P, Patel A, Bansal H, Madduri VKS, Kumar N, Mandal S, Kumar V, Jose S, Nelivigi GG, Elhence A, Singh H.   +15 more
europepmc   +1 more source

Guided Sample Pooling in Human Mass Balance Studies: A Recommended Strategic Decision Framework

Clinical Pharmacology &Therapeutics, EarlyView.
Radiolabeled human mass balance studies are crucial for identifying circulating metabolites and understanding drug absorption, excretion, and clearance pathways. Metabolite profiling involves quantifying all drug‐related entities, including parent drug and metabolites in plasma and excreta, using extended liquid chromatography methods coupled with ...
Filip Cuyckens, Wenying Li, Adam M. Auclair, Kenneth C. Cassidy, Cathy Cantalloube, Gary Collins, Alexander D. James, Chris Gibson, Ulrike Glaenzel, Felix Huth, Ping Kang, Patricia Moliner, Mette L. Pedersen, Isabel Piel, Pietro Brunetti, Hanno Schieferstein, David Wagner, Gregory S. Walker, Shuai Wang, Qin Yue, Jason Boer, Cyrus Khojasteh   +21 more
wiley   +1 more source

Synchronous renal clear cell carcinoma and lung adenocarcinoma with adrenal metastasis: A case report

Asian Journal of Surgery
Yijie Xie, Zhengsheng Liu, Bin Chen, Peide Bai   +3 more
doaj   +1 more source