Results 61 to 70 of about 2,543,947 (256)

The Natural Product Corramycin Acts as a DNA Gyrase Poison and Overcomes Fluoroquinolone Resistance in Mycobacterium tuberculosis

Advanced Science, EarlyView.
Corramycin, a myxobacterial natural product antibiotic, exhibits potent bactericidal activity against multidrug‐resistant Mycobacterium tuberculosis. The compound hijacks bacterial transporters such as BacA and OppABCD to enter the cell and inhibits DNA synthesis through a previously unrecognized mode of DNA gyrase poisoning, locking the enzyme in an ...
Franziska Fries, Jennifer Herrmann, Michael Dal Molin, Yaëlle Wormser, Timo Risch, Yunsheng Gao, Gareth Prosser, Francesca Gubellini, Ariel Mechaly, Joshua B. Wallach, Anthony Castro, Arka Banerjee, Sari Rasheed, Alexander Horn, Mathias Müsken, Michael Kurz, Lindsay Sonnenkalb, Viola Dreyer, Stefan Niemann, Sönke Andres, Dirk Schnappinger, Uli Kazmaier, Norbert Reiling, Rolf Müller, Jan Rybniker, Stéphanie Petrella   +25 more
wiley   +1 more source

Gut Microbiota‐Isoallolithocholic Acid Crosstalk Promotes Calcium Oxalate Kidney Stone Formation via PARP1‐Mediated Parthanatos

Advanced Science, EarlyView.
ABSTRACT Bile acids have been implicated in calcium oxalate (CaOx) nephrolithiasis. Here, we employ multi‐omics approaches to identify isoallolithocholic acid (isoalloLCA) as the key bile acid elevated in the feces, serum, kidney, and urine of CaOx rats, confirmed by spatial metabolomics.
Zijian Zhou, Ruixi Yu, Xuan Zhou, Feng Shi, Zeyu Lin, Peng Gao, Lujia Wang, Ninghan Feng, Zhong Wu, Dawei Wang   +9 more
wiley   +1 more source

The Relation between Treated Maternal Urinary Tract Infection and Adverse Maternal, Prenatal Outcomes in Pregnant Women of Ardabil, Iran [PDF]

Background and Objective: ­ Urinary tract infection is one of the most common bacterial infections during pregnancy and has also been implicated as a risk factor for adverse maternal and prenatal ­­outcomes.
مرادی, شهلا, نخستین, بابک, حضرتی, صادق, سلیمی, سوسن, طهماسبی, پریسا, عالی جهان, راحله   +5 more
core  

Natural Product Toosendanin Suppresses the Malignant Development of Skin Melanoma by Targeting BNC2 for Degradation

Advanced Science, EarlyView.
BNC2 exhibits context‐dependent opposing functions across multiple cancer types. This study reveals BNC2 as an oncogenic driver of melanoma proliferation and metastasis through transcriptional activation of PIK3CA. The natural compound TSN simultaneously degrades BNC2 and its oncogenic partner SMAD3 via CRBN‐dependent ubiquitination.
Hui Dai, Xin Mei Zhang, Jing Cheng Zhang, Xu Ting Deng, Qiao Liu, Mustafa Hussein Ali, Fang Zhou Yin, Wu Yin   +7 more
wiley   +1 more source

Urinary tract infections in seniors initiated by Proteus spp.

Journal of Education, Health and Sport, 2019
Background: Urinary tract infection is a bacterial infection of the urinary tract or kidneys. The most common affliction affects the elderly. Depending on the age, gender, and comorbidities, there are many factors that cause UTI.
Mateusz Porada, Jakub Husejko, Natalia Skierkowska, Małgorzata Gajos, Monika Prylińska, Beniamin Szmelcer, Weronika Topka, Mateusz Modrzejewski, Mariusz Wąsicki, O. Wysocka, Michał Wilczyński, Kornelia Kędziora-Kornatowska   +11 more
doaj   +3 more sources

An Urethral Stone Mimicking Urinary Tract Infection in a Twenty-six-month-old Boy

, 2015
A 26-month-old boy, who was misdiagnosed with urinary tract infection, was admitted to our hospital with increasing complaints of uneasiness, vomiting and nausea.
Mehmet Giray Sönmez, Mehmet Giray SönmezCengiz Kara   +1 more
core   +1 more source

Comparison of Minimally Invasive Colectomy Between Intra‐ Versus Extra‐Corporeal Anastomosis Technique (COMMIT Study): Short‐Term Analysis

Annals of Gastroenterological Surgery, EarlyView.
This multicenter propensity score‐matched study of 3213 patients compared intracorporeal (IA) and extracorporeal (EA) anastomosis during minimally invasive colectomy. IA was associated with a significantly lower incidence of intraoperative blood loss ≥ 200 mL (2.5% vs.
Takuya Takami, Takehito Yamamoto, Yoshiro Itatani, Ryosuke Mizuno, Kae Okoshi, Yasunori Deguchi, Keiji Nagata, Tomoaki Okada, Rei Mizuno, Kazutaka Obama   +9 more
wiley   +1 more source

Impact of Postoperative Infectious Complications on Long‐Term Survival After Curative Resection for Colorectal Cancer: A Multicenter Study in the Minimally Invasive Era

Annals of Gastroenterological Surgery, EarlyView.
Postoperative infectious complications (PICs) have been associated with poor long‐term outcomes after colorectal cancer surgery, but evidence in the modern minimally invasive era remains limited. In this multicenter cohort of 5377 patients undergoing curative resection, PICs were independently associated with worse overall survival and relapse‐free ...
Takehito Yamamoto, Ryosuke Mizuno, Yoshiro Itatani, Tetsuya Shiota, Masahiro Yamada, Tadayoshi Yamaura, Mami Yoshitomi, Kazutaka Obama   +7 more
wiley   +1 more source

Risk Factors in Urinary Tract Infection

Gomal Journal of Medical Sciences, 2004
Background: There are many intrinsic and extrinsic factors risk factors which are the leading causes of urinary tract infection. To investigate the relationship of various risk factors to urinary tract infection a study was conducted on one hundred ...
M. Ramzan, S. Bakhsh, A. Salam, G. M. Khan, Ghulam Mustafa   +4 more
doaj   +2 more sources

Mechanistic insights into phage dynamics to overcome intracellular bacterial reservoirs in urinary tract infections

npj Viruses
Recurrent urinary tract infections frequently arise from uropathogenic bacteria invading bladder epithelial cells, where they establish persistent intracellular reservoirs.
Simone C. Lieberknecht-Jouy, Dajana Pavlovic, Carmen Aguilar, Simon Peters, Lucas J. Fein, Mathias Müsken, Tobias Weirauch, Annika Y. Classen, Olaf Tyc, Silvia Würstle, Thomas A. Wichelhaus, Maria J. G. T. Vehreschild   +11 more
doaj   +1 more source