Results 241 to 250 of about 381,673 (307)
Abstract Fenofibrate is contraindicated in patients with advanced hepatic fibrosis due to limited clinical data. We evaluated the pharmacokinetics and safety of fenofibrate in participants with mild hepatic impairment (phase 1 study) or advanced fibrosis due to metabolic‐associated fatty liver disease (MAFLD; phase 2a study).
Islam R. Younis+5 more
wiley +1 more source
Effects of Hepatic or Renal Impairment on Pharmacokinetics of Fruquintinib
Abstract Fruquintinib (FRUZAQLATM) is a highly selective tyrosine kinase inhibitor of all three vascular endothelial growth factor receptors (‐1, ‐2, and ‐3). Two Phase 1, open‐label, single‐dose studies investigated the impact of hepatic or renal impairment on the pharmacokinetics and tolerability of fruquintinib.
Martha Gonzalez+8 more
wiley +1 more source
Abstract Background Acute uncomplicated cystitis (AUC) is a urinary tract infection and is generally treated using antimicrobial therapy. Escherichia coli is the main causative agent of AUC. Recently, the prevalence of fluoroquinolone (FQ)‐resistant‐E. coli has demonstrated a noticeable increase. In this study, we aimed to investigate the effectiveness
Takuhisa Nukaya+2 more
wiley +1 more source
Clinical progress note: Pertussis
Abstract Pertussis, commonly known as whooping cough, is a vaccine‐preventable respiratory disease with rising incidence due to declining vaccination rates and waning immunity. The most severe disease course is seen in unvaccinated or incompletely vaccinated infants less than 2 months of age, accounting for the largest burden of hospitalization and ...
Samantha Hanna, Nicole Samies
wiley +1 more source
Standardized hydrostatic enemas improve the intestinal outcome in premature infants. Abstract Objective This study evaluated the safety and efficacy of standardized minimally invasive hydrostatic low‐volume saline enemas in infants with a birth weight ≤1000 g or gestational age ≤28 weeks and delayed meconium passage.
Tabea Stock+4 more
wiley +1 more source
Pharmacists in aged care: outcomes of a national stakeholders meeting
Abstract Background Medicine safety is a critical concern for Australia's growing aged‐care population. Pharmacists play a vital role in improving medicines management, but their integration into aged‐care settings requires careful planning. Aim To report on the outcomes of a national meeting of stakeholders in Australia exploring the integration of ...
Kate Wang+10 more
wiley +1 more source
Complications Following Open Versus Minimally Invasive Resection of Gastric Adenocarcinoma
ABSTRACT Background and Objectives Gastric adenocarcinoma (GA) is commonly treated with open or minimally invasive surgery (MIS). The preferred surgical approach remains unclear. This study sought to assess utilization over time, compare complication rates by surgical approach, and identify predictors of experiencing complications. Methods Patients who
Kelly R. Bates+5 more
wiley +1 more source