Results 61 to 70 of about 306,928 (307)

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Mechanism of the blood pressure-lowering effect of sodium-glucose cotransporter 2 inhibitors in obese patients with type 2 diabetes

BMC Pharmacology and Toxicology, 2017
Background Sodium-glucose cotransporter 2 (SGLT2) inhibitors are reported to have BP-lowering effect in addition to blood glucose-lowering effect, however, its mechanism is still unknown.
Shin Kawasoe, Yukiko Maruguchi, Shoko Kajiya, Hitoshi Uenomachi, Masaaki Miyata, Mariko Kawasoe, Takuro Kubozono, Mitsuru Ohishi   +7 more
doaj   +1 more source

Establishing an assay to evaluate d‐amino acid oxidase enzyme kinetics and inhibition using WST‐8 redox dye

FEBS Open Bio, EarlyView.
This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake, Yuki Enoki, Yuka Nakazawa, Kazuaki Taguchi, Kazuaki Matsumoto   +4 more
wiley   +1 more source

Prostate Volume and Urinary Discomforts in Elderly

Collegium antropologicum, 2015
Occasional doubts about the real effect of the prostate volume on the urinary discomforts that elderly have been experiencing required additional assessment of these parameters. The aim of this study was to re-evaluate relationship between the urinary discomforts of the elderly and the prostate volume in comparison with age.
Tadin, Tomislav, Španjol, Josip, Muškardin, Ivo, Fučkar, Željko   +3 more
openaire   +3 more sources

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Metabolic investigation in patients with nephrolithiasis

Einstein (São Paulo)
: Objective: To evaluate the prevalence of metabolic disorders associated with nephrolithiasis in a female population. Methods: A retrospective study on 1,737 patients with evidence of recent formation of renal stones, being 54% females. The laboratory
Francilayne Moretto dos Santos, Aline Krampe Peres, Michel Roberto Mandotti, Luis Alberto Batista Peres   +3 more
doaj   +1 more source

Movement Disorders in Aicardi–Goutières Syndrome and Response to Immunomodulation

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT This study characterizes movement disorders and treatment responses in seven children with Aicardi–Goutières syndrome (AGS). We retrospectively evaluated motor phenotypes, neuroimaging, and interferon signatures in patients treated with baricitinib or anifrolumab. Spasticity affected all patients, while dystonia was present in 4/7.
Enrique Gonzalez Saez‐Diez, Monica Ferrer Socorro, Kathryn Yang, Nicole Battaglia, Zainab Zaman, Mariko Bennett, Adeline Vanderver, Pui Y. Lee, Lauren A. Henderson, Milena M. Andzelm, Darius Ebrahimi‐Fakhari   +10 more
wiley   +1 more source

USO DE LA EXCRECIÓN DE CREATININA COMO MÉTODO ALTERNATIVO A LA COLECTA TOTAL DE ORINA EN VACAS HOLSTEIN USE OF THE CREATININE EXCRETION AS ALTERNATIVE METHOD TO TOTAL URINE COLLECTION IN HOLSTEIN COWS

Revista Facultad Nacional de Agronomía Medellín, 2010
La investigación en producción animal requiere la recolección total de orina, para estimar la excreción de compuestos nitrogenados y derivados púricos, lo cual trae grandes dificultades, siendo necesario buscar técnicas alternas.
Libardo Escobar Puerta, Diana María Bolívar Vergara, Diana Espinoza García   +2 more
doaj  

DEVELOPMENT OF BLADDER CAPACITY, NOCTURNAL URINARY VOLUME AND URINARY BEHAVIOR IN NONENURETIC AND ENURETIC CHILDREN

The Japanese Journal of Urology, 1993
Bladder capacity, nocturnal urinary volume and nocturnal urinary behavior were investigated in 1751 nonenuretic and 282 enuretic children in two primary schools and four kindergartens. The results were as follows: 1. A statistically significant linear correlation was observed between the age and the bladder capacity in the morning and daytime, as well ...
Kawauchi, Akihiro, Watanabe, Hiroki, Nakagawa, Shuichi, Miyoshi, Kunio   +3 more
openaire   +3 more sources

Influence of nutrition on feline calcium oxalate urolithiasis with emphasis on endogenous oxalate synthesis

, 2011
The prevalence of calcium oxalate (CaOx) uroliths detected in cats with lower urinary tract disease has shown a sharp increase over the last decades with a concomitant reciprocal decrease in the occurrence of struvite (magnesium ammonium phosphate ...
Plantinga, E.A., Baal, J., van, Dijcker, J.C., Hendriks, W.H.   +3 more
core   +1 more source