Results 61 to 70 of about 78,525 (327)

Esketamine/Ketamine: Dual‐Action Mechanisms and Clinical Prospects beyond Anesthesia in Psychiatry, Immunology, and Oncology

open access: yesAdvanced Science, EarlyView.
Esketamine and ketamine are widely used for perioperative analgesia and anesthesia. Despite their established roles in analgesia, sedation, and anesthesia, as well as emerging antidepressant, anti‐tumor, and anti‐inflammatory effects, their clinical use is limited due to side effects and addiction potential.
Yinxin Wang   +7 more
wiley   +1 more source

Can feeling of incomplete bladder emptying reflect significant postvoid residual urine? Is it reliable as a symptom solely? [PDF]

open access: yesInvestigative and Clinical Urology, 2018
Purpose: The main objective of this study was to reveal the relationship between lower urinary tract symptoms (LUTS) and post-void residual (PVR) urine volume.
Yusuf Özlülerden   +6 more
doaj   +1 more source

The Accessible Toilet Design Resource [PDF]

open access: yes, 2007
This Accessible Toilet Design Resource has been produced from new primary research carried out within VivaCity 2020, a large university-based research consortium that is developing tools and resources to support the design of socially inclusive cities ...
Bichard, Jo-Anne   +2 more
core  

Functioning and disability in multiple sclerosis from the patient perspective [PDF]

open access: yes, 2011
Multiple sclerosis (MS) has a great impact on functioning and disability. The perspective of those who experience the health problem has to be taken into account to obtain an in-depth understanding of functioning and disability.
Alarcos Cieza   +13 more
core   +1 more source

Disrupting CSPG‐Driven Microglia–Astrocyte Crosstalk Enables Scar‐Free Repair in Spinal Cord Injury

open access: yesAdvanced Science, EarlyView.
This study identifies CSPGs as key drivers of glial scar maturation after spinal cord injury by reprogramming microglial metabolism and inducing astrocyte fibrosis. To address this, a reactive oxygen species‐responsive, reactive astrocyte‐targeted ChABC gene delivery system is designed to locally degrade CSPGs, precisely disrupt maladaptive glial ...
Yufei Zheng   +10 more
wiley   +1 more source

A COMPARATIVE STUDY OF THE DIURETIC AND CHOLERETIC ACTIVITY OF POWDERS AND EXTRACTS FROM THE FRUIT OF WILD CARROT AND CARROT SEED

open access: yesСовременная наука и инновации, 2022
In the course of experiments on healthy white rats and rats with paracetamol intoxication established unidirectional choleretic and diuretic effects of alcohol powders and extracts from fruits and seeds of wild carrot, greater than or comparable with the
Svetlana Sergeevna Sigareva   +2 more
doaj  

A rare case of urethral fibroepithelial polyp in a young boy

open access: yesUrology Case Reports, 2023
Urethral fibroepithelial polyps are uncommon benign tumors. The clinical presentation comprises of acute urinary retention, obstructive bladder symptoms such as frequent urination and urination difficulties, and hematuria.
Eyup Burak Sancak   +2 more
doaj   +1 more source

Community Knowledge, Perceptions, and Practices Associated with Urogenital Schistosomiasis among School-Aged Children in Zanzibar, United Republic of Tanzania [PDF]

open access: yes, 2016
Background: On the Zanzibar islands, United Republic of Tanzania, elimination of urogenital schistosomiasis is strived for in the coming years. This qualitative study aimed to better understand community knowledge, perceptions, and practices associated ...
A'Kadir, Faiza M.   +7 more
core   +3 more sources

A Sirtuin‐1‐Targeted Gene‐Activating Tetrahedral DNA Attenuates Bladder Fibrosis by Restoring Mitophagy in Fibroblasts via the SIRT1‐FOXO3‐BNIP3 Axis

open access: yesAdvanced Science, EarlyView.
The SIRT1‐targeted saRNA‐delivering tetrahedral DNA (TSA) treatment effectively upregulates SIRT1 expression, which subsequently promotes FOXO3A deacetylation. This deacetylation event relieves FOXO3A's transcriptional repression on the BNIP3 gene, thereby initiating PINK1‐PARKIN‐dependent mitophagy.
Wei Wang   +10 more
wiley   +1 more source

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