Results 71 to 80 of about 2,991,346 (289)
Advanced Science, EarlyView.The SIRT1‐targeted saRNA‐delivering tetrahedral DNA (TSA) treatment effectively upregulates SIRT1 expression, which subsequently promotes FOXO3A deacetylation. This deacetylation event relieves FOXO3A's transcriptional repression on the BNIP3 gene, thereby initiating PINK1‐PARKIN‐dependent mitophagy.
Wei Wang +10 more
wiley +1 more source
Disease modifying therapy for multiple system atrophy – Parkinsonian Type [PDF]
, 2017 BACKGROUND: Multiple System Atrophy –Parkinsonian Type (MSA-P) is a rare, rapidly progressive neurodegenerative disease without any current treatment.
Dwyer, Sean Sullivan
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Australian Journal of Social Issues, EarlyView.ABSTRACT This study explores youth violence towards police officers in Australia through the Power Threat Meaning Framework (PTMF) to better understand the underlying factors contributing to such violence; focusing on power dynamics, childhood adversity, and trauma.
Dimitra Lattas +4 more
wiley +1 more source
Heliyon, 2023 Purpose: To compare the safety, feasibility, and effectiveness of transvaginal natural orifice transluminal endoscopic sacrocolpopexy (vNOTES-SC) and laparoendoscopic single-site sacrocolpopexy (LESS-SC) for pelvic organ prolapse (POP).
Yan Chen +7 more
doaj +1 more source
Invisible Wounds: The Impact of Six Years of War on the Mental Health of Syria's Children [PDF]
, 2017 The TDR Results Report illustrates progress made against the 23 key performance indicators that are part of the monitoring and evaluation matrix, in line with the current Performance Assessment Framework.The report shows progress made on various ...
Alun McDonald
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, 2014 Neurotoxicity refers to the direct or indirect effect of chemicals that disrupt the nervous system of humans or animals. Numerous chemicals can produce neurotoxic diseases in humans, and many more are used as experimental tools to disturb or damage the ...
Brust +15 more
core +2 more sources
Interdisciplinary Medicine, EarlyView.Under hyperglycemic conditions, mitochondrial dysfunction in retinal endothelial cells triggers excessive reactive oxygen species/reactive nitrogen species production, barrier protein degradation, and endothelial barrier breakdown in diabetic retinopathy.
Siyu Gui +12 more
wiley +1 more source
Interdisciplinary Medicine, EarlyView.Organoids and organ‐on‐a‐chips are advancing reproductive system research. In the female reproductive system, applications include cancer organoid models, placental chips, and hormone simulation models. For the male reproductive system, research focuses on drug resistance mechanisms, co‐culture platforms, and infertility studies. These refined in vitro
Hongqi Zhang +6 more
wiley +1 more source
Type 2 diabetes mellitus patients’ lived experience at a tertiary hospital in Ekiti State, Nigeria
Scientific Reports, 2022 Diabetes mellitus is a complex and chronic metabolic disorder that is associated with multiple complications and disabilities. This contributes to increased mortality and poor quality of life among affected individuals.
Anthonia I. Okurumeh +3 more
doaj +1 more source
Effectiveness of Acuyoga (Accupresure and Yoga) Antenatal and Pregnancy Massage Against Intensity of Back Pain and Sleep Disturbance in Third Trimester Pregnant Woman in Dr.Aisyatul Mukminah Sp.OG (K)'s Practice in Tulungagung [PDF]
, 2017 Various physiological changes occur in the mother's body during pregnancy which can affect the occurrence of low back pain and sleep disturbance during pregnancy trimester 3.
Indasah, I. (Indasah) +2 more
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