Results 71 to 80 of about 77,909 (259)

The pharmacokinetics of inulin and urea: a comparison of the dose eliminated from a compartmental model and that eliminated in urine

Journal of Pharmacy and Pharmacology, 1972
Abstract The distribution kinetics of inulin and urea were studied in the male rat to test the validity of a proposed compartmental model. The plasma curves could be adequately described by a biexponential function. For inulin, analysis of the results gave valid parameters in terms of an open two compartment model.
G R, Bourne, H E, Barber
openaire   +2 more sources

Canagliflozin Alleviates Diabetic Glomerular Endothelial Injury via Melibiose in a Microbiota‐Dependent Manner

Advanced Science, EarlyView.
Canagliflozin treatment reshapes the gut microbiota in DKD and elevates levels of melibiose, a metabolite derived from Roseburia intestinalis. Melibiose directly binds to and enhances the enzymatic activity of glyoxalase 1, leading to decreased methylglyoxal accumulation.
Wei Zhang, Yi Song, Changkun Li, Yuanyuan Luo, Mingwei Shao, Feng Guo, Fangyi Wei, Xunjie Fan, Wenwen Guo, Fengmei Xu, Yanhong Sang, Dongming Zhang, Yanhong Zhou, Lianwei Wang, Zhiqiang Kang, Yingjun Yang, Chunhua Song, Yanxia Liu, Xiaojun Ma, Jiao Wang, Chong Li, Shengnan Ma, Lin Zhao, Zhi Qin, Guolan Xing, Qiubo Zhao, Jun Li, Shumin Song, Dan Zhao, Ting Huang, Qingzhu Wang, Yanyan Zhao, Guijun Qin   +32 more
wiley   +1 more source

Study on the Excretion of a New Antihypertensive Drug 221s (2,9) in Rats

Pharmaceuticals
Background/Objectives: The novel compound 221s (2,9), derived from danshensu and ACEI-active proline, exhibits antihypertensive effects (50/35 mmHg SBP/DBP reduction in SHRs) with potential cough mitigation.
Yunmei Chen, Kuan Yang, Shaojing Liu, Lili Yu, Rong Wang, Bei Qin   +5 more
doaj   +1 more source

THE ELIMINATION OF POTASSIUM IODID IN THE URINE [PDF]

Journal of the American Medical Association, 1915
This work was entirely confined to the study of the urinary elimination of potassium iodid after oral or rectal administration. The patients of the general ward type were given 1 gram of potassium iodid and the urine was subsequently examined to determine the total amount of potassium iodid excreted day after day, until the last traces had disappeared.
openaire   +2 more sources

Stress History Establishes a Transient Tolerant State That Shapes Antibiotic Survival Upon Resuscitation

Advanced Science, EarlyView.
High‐throughput single‐cell analysis of resuscitating bacteria reveals a starvation‐history‐dependent transiently tolerant subpopulation that survives β$\beta$‐lactam exposure by temporarily reducing growth. Distinct from classical persisters, these actively growing yet dynamically modulated cells dominate survival across clinically relevant antibiotic
Kieran Abbott, Georgeos Hardo, Ruizhe Li, Jack Bradley, Ashraf Zarkan, Somenath Bakshi   +5 more
wiley   +1 more source

Impact of lactoferrin supplementation on cotrimoxazole pharmacokinetics: A preliminary clinical investigation

ADMET and DMPK
Background and Purpose: Cotrimoxazole, a commonly prescribed antibiotic, has substantial resistance, especially in Indonesia, with its uropathogenic resistance reaching 67% in 2017.
Dion Notario, Angela Marietha Munzir, Yulina Novella, Linawati Hananta   +3 more
doaj   +1 more source

THE ELIMINATION OF ARSPHENAMIN AND NEO-ARSPHENAMIN IN THE URINE [PDF]

Archives of Dermatology and Syphilology, 1922
The need for a simple, and at the same time accurate, means by which the elimination of arsphenamin and its derivatives can be studied in the urine is apparent. In a paper read before the Section on Dermatology and Syphilology of the Thirteenth International Medical Congress held at London in 1913, Vennin, 1 a French army surgeon, has well stated the ...
openaire   +2 more sources

The Development and Pilot Clinical Study of CD147 Targeted Antagonistic Peptide Probe for Tumor Imaging

Advanced Science, EarlyView.
This study establishes [68Ga]Ga‐DOTA‐AP9 as a first‐in‐human CD147‐targeted PET tracer with favorable safety and specific tumor uptake. Tracer accumulation correlates with CD147 expression in patients, enabling noninvasive quantification of CD147‐positive malignancies.
Xiaokun Ma, Rui Guo, Dongfeng Niu, Yufei Song, Zhenyao Zhang, Xiangxi Meng, Lili Mao, Haifeng Huang, Hua Zhu, Zhi Yang, Teli Liu   +10 more
wiley   +1 more source

Metabolism and Excretion of Intravenous, Radio-Labeled Amisulpride in Healthy, Adult Volunteers

Clinical Pharmacology: Advances and Applications, 2019
Gabriel M Fox,1 Ad F Roffel,2 Jan Hartstra,2 Linda A Bussian,3 Sjoerd P van Marle2 1Department of Clinical Development, Acacia Pharma Ltd, Cambridge, UK; 2PRA Health Sciences, Groningen, the Netherlands; 3Comedica Ltd, Cambridge, UKCorrespondence ...
Fox GM, Roffel AF, Hartstra J, Bussian LA, van Marle SP   +4 more
doaj  

TME/NIR Dual‐Responsive Zinc‐Based Targeted Nanoagonist for Multimodal Amplification of STING‐Mediated Cancer Immunotherapy

Advanced Science, EarlyView.
A multifunctional nanoagonist (cDZ@IP) enables nano‐metabolite–driven multimodal activation of the STING pathway and enhanced immune recognition, achieving potent antitumor immunity and suppressing tumor growth and metastasis. This strategy highlights the rational design of therapeutic metabolites and establishes a new paradigm bridging nanomedicine ...
Kepeng Hu, Jiawei Wang, Wei Zhang, Zhixuan Wu, Jing Chen, Yujing He, Xiyue Duan, Yaoting He, Xin Xin, Haoyi Xiang, Yijing Wang, Chengwei Wu, Yang Yi, Qing Meng, Yuqian Qiao, Kui Cheng, Xiaojun Long, Zhangfa Song   +17 more
wiley   +1 more source