Results 121 to 130 of about 30,054 (246)

Periodontal Medicine Rewired: Mechanisms Linking Periodontitis to Systemic Diseases

Journal of Periodontal Research, EarlyView.
This review reorganizes decades of research in periodontal medicine into a multi‐dimensional framework, illustrating how periodontitis influences systemic health through at least seven interconnected mechanisms. ABSTRACT Periodontitis is now recognized not merely as a localized oral condition but as a systemic disease linked to over 70 communicable and
Mario Romandini, George Hajishengallis, Mike Curtis, Giacomo Baima   +3 more
wiley   +1 more source

Human Pappilomavirus Genotype in Cervical Tissue of Patients with Cervical Intraepithelial Neoplasia (CIN) 1, CIN 2, and CIN 3 [PDF]

, 2016
Objectives: to determine the genotype of HPV in patients with precancerous lesions of cervical tissue.Materials and Methods: An observational study with cross sectional study of patients paraffin block CIN1, CIN2, CIN3 was conducted in Dr Soetomo ...
Alia, R. (Rahmi), I’tishom, R. (Renny), Mastutik, G. (Gondo), Rahaju, A. S. (Anny), Rahniayu, A. (Alphania)   +4 more
core   +1 more source

Ophiopogonin D Mediates Therapeutic Effects on Primary Sjögren's Syndrome by Modulating Gut Microbiota and Metabolite Profiles

Biomedical Chromatography, Volume 40, Issue 6, June 2026.
ABSTRACT This study aimed to investigate the mechanism of ophiopogonin D (OD) in treating primary Sjögren's syndrome (pSS) through integrated analysis of gut microbiota and metabolomics. Non‐obese diabetic/LtJ mice, a well‐established pSS model, were used as the model group and treated with OD or hydroxychloroquine.
Fengtao Pang, Xueyan Shan, Yi Kong, Xiaopo Tang   +3 more
wiley   +1 more source

Nanoshell Fabrication Techniques for Probiotic Encapsulation: A Comprehensive Review

eFood, Volume 7, Issue 3, June 2026.
ABSTRACT Probiotics, beneficial microorganisms, confer numerous health benefits when administered. However, their efficacy is hindered by harsh gut conditions, including acidity, bile acids, and enzymatic degradation. To overcome these challenges, encapsulation and nanoshell technology have emerged as a pivotal strategy to enhance probiotic stability ...
Tuba Mustafa, Muhammad Afzaal, Farhan Saeed, Amna Shahbaz, Zainab Hira, Ayesha Adil, Tayyaba Sohail, Faiyaz Ahmed, Maryam Amanullah, Hina Sarwar, Noor Akram, Saad Mansoor, Gebremichael Gebremedhin Hailu   +12 more
wiley   +1 more source

Repeated versus single praziquantel dosing regimen in treatment of female genital schistosomiasis: a phase 2 randomised controlled trial showing no difference in efficacy

Frontiers in Tropical Diseases
BackgroundSingle-dose praziquantel (PZQ) for treating urogenital schistosomiasis has been reported as inadequate for achieving significant resolution of female genital schistosomiasis (FGS)-associated cervicovaginal lesions.
Louise Thomsen Schmidt Arenholt, Louise Thomsen Schmidt Arenholt, Louise Thomsen Schmidt Arenholt, Bodo Sahondra Randrianasolo, Tiana Onintsoa Oliva Rabozakandraina, Charles Emile Ramarokoto, Karoline Jøker, Katrina Kæstel Aarøe, Dorthe Brønnum, Caspar Bundgaard Nielsen, Suzette Sørensen, Suzette Sørensen, Suzette Sørensen, Mads Lumholdt, Martin Jensen, Søren Lundbye-Christensen, Jørgen Skov Jensen, Paul Corstjens, Pytsje Hoekstra, Govert J van Dam, Noriko Kobayashi, Noriko Kobayashi, Shinjiro Hamano, Shinjiro Hamano, Peter Derek Christian Leutscher, Peter Derek Christian Leutscher   +25 more
doaj   +1 more source

A Case of Persistent Urogenital Sinus: Pitfalls and challenges in diagnosis

Sultan Qaboos University Medical Journal, 2018
Persistent urogenital sinus (PUGS) is a rare anomaly whereby the urinary and genital tracts fail to separate during embryonic development. We report a three-year-old female child who was referred to the Sabah Women & Children Hospital, Sabah, Malaysia ...
Hooi H. Tan, Shung K. Tan, Rajah Shunmugan, Rozman Zakaria, Zakaria Zahari   +4 more
doaj   +1 more source

Functional Data Strengthen Clinical Validation of PhenoScore Phenotype‐Guided AI for ANKRD11 Missense Variants

Clinical Genetics, Volume 109, Issue 6, Page 1038-1048, June 2026.
PhenoScore, an AI framework integrating facial recognition and clinical phenotype data, accurately identifies pathogenic ANKRD11 missense variants associated with KBG syndrome (AUC 0.95). Validated against functional data, PhenoScore outperforms REVEL and complements AlphaMissense, providing objective phenotypic evidence to reduce variants of uncertain
Evi Andriessen, Elke de Boer, Gholson J. Lyon, Bert B. A. de Vries, Charlotte W. Ockeloen, Alexander J. M. Dingemans   +5 more
wiley   +1 more source

Urological management in a pediatric patient with mixed gonadal dysgenesis

Urology Case Reports
Disorders of sex development are conditions characterized by alterations in gonadal development that lead to discordance between chromosomal sex, gonadal sex, and phenotypic sex. We report the case of a 4 years old patient with ambiguous genitalia and 45,
Wendy Matilde Chipa Beizaga, Luis José Orbegoso Celis, Brandom Juced Torres Marigorda, Miguel Martín Aguilar Ulloque, Kilder Nicolay García Murga, Valeria Linares Vega, Fernando Jeancarlos Imán Izquierdo, Ronald Aquino-Ortega, Juana del Valle-Mendoza, Wilmer Gianfranco Silva-Caso   +9 more
doaj   +1 more source

Laparoscopic Reimplantation for Single-System Ectopic Ureter [PDF]

, 2009
INTRODUCTION Ureteral anomalies, ectopic ureter being one of them, are of the most important urogenital abnormalities because they directly affect kidney function.(1) Several techniques have been used for treatment of ectopic ureter.
Abdi, Hamidreza., Basiri, Abbas., Mahmoudnejad, Nastaran., Mohammad Ali Beigi, Faramarz.   +3 more
core  

KDM2B‐Related Neurodevelopmental Disorder A Case‐Series Supporting the CxxC Domain Phenotype With Emphasis on Ocular and Dermatologic Features

American Journal of Medical Genetics Part A, Volume 200, Issue 5, Page 1098-1104, May 2026.
ABSTRACT The KDM2B‐related neurodevelopmental disorder is a recently identified Mendelian disorder of the epigenetic machinery associated with pathogenic variants in KDM2B. Global developmental delay, intellectual disability, congenital anomalies, and systemic manifestations characterize the disorder.
Adriana Gomes, Álvaro Martín‐Rodríguez, Miguel Del Campo, Lynne M. Bird   +3 more
wiley   +1 more source