Results 31 to 40 of about 16,503 (187)

Urogenital abnormalities in men exposed to diethylstilbestrol in utero: a cohort study

Environmental Health, 2009
Background Diethylstilbestrol (DES), a synthetic estrogen widely prescribed to pregnant women during the 1940s–70s, has been shown to cause reproductive problems in the daughters.
Palmer Julie R, Herbst Arthur L, Noller Kenneth L, Boggs Deborah A, Troisi Rebecca, Titus-Ernstoff Linda, Hatch Elizabeth E, Wise Lauren A, Strohsnitter William C, Hoover Robert N   +9 more
doaj   +1 more source

Endothelial PDGF Signaling Dysregulation Impairs Testicular Interstitial Homeostasis in Diabetes

Advanced Science, EarlyView.
Testicular endothelial cells (TECs) function as central signaling hubs that coordinate interstitial homeostasis. Diabetes disrupts TEC‐derived PDGF signaling, silences the JUND‐MCL1 survival program in Leydig cells, and impairs peritubular function, leading to fibrosis and testosterone insufficiency.
Wenxiu Zhang, Kai Hong, Yanling Tang, Lina Cui, Xiaojian Lu, Jianxing Cheng, Yangyi Fang, Qiaoling Jiang, Ziyan Zhuang, Songzhan Gao, Hui Jiang, Qiang Liu, Jingtao Guo, Zhe Zhang, Xiaoyan Wang   +14 more
wiley   +1 more source

Comparison of the Surgical Results of Ventral and Dorsal Dartos Flaps in Tubularized Incised Plate Urethroplasty for Distal Hypospadias: A Randomized Clinical Trial

Urology Research and Practice
Objective: Hypospadias is one of the most common congenital anomalies of the uro genital system. Various surgical methods exist to repair this condition, all aiming to create a straight penis, ensure proper placement of the meatus, and achieve a ...
Fateme Tahmasbi, Javad Aliasgarzadeh, Mohsen Mohammad-Rahimi, Behzad Lotfi   +3 more
doaj   +1 more source

Abnormal development of urogenital organs in Dlgh1-deficient mice [PDF]

Development, 2007
Dlgh1 (discs large homolog 1) is a mammalian homolog of the Drosophila tumor suppressor Discs large 1, and is a member of the membrane-associated guanylate kinase (MAGUK) scaffolding proteins that contain three PSD-95/Dlg/ZO-1 (PDZ) domains. Discs large 1 is involved in epithelial polarization and cell-cell adhesion complex formation during Drosophila ...
Akiko, Iizuka-Kogo, Takefumi, Ishidao, Tetsu, Akiyama, Takao, Senda   +3 more
openaire   +2 more sources

Therapeutic Gases in Biomedicine: Updates on Nitric Oxide and Beyond

Advanced Science, EarlyView.
Therapeutic gases, including NO, CO, H2S, H2, CO2, O2, and Xe, play vital roles in cellular signaling and repair. This review highlights the emerging carriers and delivery systems that enable controlled, localized gas release for diagnostic and therapeutic applications.
Syed Muntazir Andrabi, Navatha Shree Sharma, Imran Ibn Gani Rather, S. M. Shatil Shahriar, Jingwei Xie   +4 more
wiley   +1 more source

Complete dorsal pancreatic agenesis and unilateral renal agenesis

Radiology Case Reports, 2018
Dorsal pancreatic agenesis is a very rare congenital anomaly. Unilateral renal agenesis, on the other hand, is a relatively common congenital anomaly, although its etiology is not fully understood.
Adriana Moreira, MD, André Carvalho, MD, Inês Portugal, MD, José Miguel Jesus, MD   +3 more
doaj   +1 more source

Herlyn-Werner-Wunderlich syndrome with double hematocolpos in one side hemivagina

Clinical and Experimental Obstetrics & Gynecology, 2022
Background: Herlyn-Werner-Wunderlich syndrome (HWWS) is an extremely rare Mullerian anomaly consisting of uterus didelphys with obstructed hemivagina and ipsilateral renal agenesis.
You Jin Kim, Jung Bo Yang, Ye Won Jung, Soo Youn Song, Geon Woo Lee, Heon Jong Yoo   +5 more
doaj   +1 more source

Differentiating the Clinical and Variant Spectrum of Hardikar Syndrome From Other MED12‐Related Developmental Disorders

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT The rare X‐linked female‐restricted Hardikar syndrome (HDKR, OMIM # 301068) is characterized by multiple congenital anomalies including orofacial clefts, gastrointestinal, genitourinary, and cardiac anomalies, but cognitive and neurobehavioral development is rarely impaired.
Tinne Warmoeskerken, Miel Theunis, Kris Van den Bogaert, Koenraad Devriendt, Jeroen Breckpot   +4 more
wiley   +1 more source

Assessment of quality of life based on psychological, somatovegetative, and urogenital health problems among postmenopausal women in Urban Puducherry, South India: A cross-sectional observational study

Journal of Mid-Life Health, 2018
Background: An average Indian woman spends almost one-third of her lifespan in the postmenopausal phase enduring the consequences of hormonal decline. This can have a significant impact on quality of life (QOL).
Yuvaraj Krishnamoorthy, Gokul Sarveswaran, Venkatachalam Jayaseelan, Manikandanesan Sakthivel, Yashodha Arivarasan, N Bharathnag   +5 more
doaj   +1 more source

KDM2B‐Related Neurodevelopmental Disorder A Case‐Series Supporting the CxxC Domain Phenotype With Emphasis on Ocular and Dermatologic Features

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT The KDM2B‐related neurodevelopmental disorder is a recently identified Mendelian disorder of the epigenetic machinery associated with pathogenic variants in KDM2B. Global developmental delay, intellectual disability, congenital anomalies, and systemic manifestations characterize the disorder.
Adriana Gomes, Álvaro Martín‐Rodríguez, Miguel Del Campo, Lynne M. Bird   +3 more
wiley   +1 more source