Urogenital abnormalities - Open Access .click

Results 81 to 90 of about 16,967 (166)

Multiparametric Ultrasound Findings of Testicular Sarcoidosis

Journal of Ultrasound in Medicine, Volume 45, Issue 7, Page 1497-1504, July 2026.
Objectives To characterize the multiparametric ultrasound (MPUS) features of testicular sarcoidosis, incorporating greyscale, color Doppler ultrasound (CDUS), contrast‐enhanced ultrasound (CEUS), and strain elastography (SE), and to assess their collective diagnostic value.
Huahui Liu +5 more
wiley +1 more source

Homozygous Loss‐of‐Function Variant in SLC20A1 Coding for Ubiquitous Phosphate Transporter PiT1 Is Associated With Multiple Developmental Abnormalities

Clinical Genetics, Volume 110, Issue 1, Page 64-72, July 2026.
Biallelic SLC20A1 loss‐of‐function variant causes a previously unrecognized multisystem developmental disorder. We report the first homozygous case presenting with tetralogy of Fallot, renal agenesis, polydactyly, and growth impairment. Transcriptome analysis of patient‐derived fibroblasts suggests significant dysregulation of pathways critical for ...
Eugénie Koumakis +9 more
wiley +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, Volume 20, Issue 6, Page 1513-1534, June 2026.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, Volume 16, Issue 6, Page 1102-1114, June 2026.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li +8 more
wiley +1 more source

Fibroblast growth factor 8: Multifaceted role in development and developmental disorder

Genes and Diseases
Fibroblast growth factor 8 (FGF8), a secreted signaling molecule, involves in regulating cell survival, proliferation, migration, and differentiation. It exhibits a highly dynamic gene expression pattern throughout embryonic development, participates in ...
Huamin Yin +4 more
doaj +1 more source

Ophiopogonin D Mediates Therapeutic Effects on Primary Sjögren's Syndrome by Modulating Gut Microbiota and Metabolite Profiles

Biomedical Chromatography, Volume 40, Issue 6, June 2026.
ABSTRACT This study aimed to investigate the mechanism of ophiopogonin D (OD) in treating primary Sjögren's syndrome (pSS) through integrated analysis of gut microbiota and metabolomics. Non‐obese diabetic/LtJ mice, a well‐established pSS model, were used as the model group and treated with OD or hydroxychloroquine.
Fengtao Pang, Xueyan Shan, Yi Kong, Xiaopo Tang +3 more
wiley +1 more source

Identification of a Novel Frameshift variant of the ATRX gene: a Case Report and Review of the genotype–phenotype relationship

BMC Pediatrics
Background X-linked intellectual disability-hypotonic facies syndrome-1 (MRXHF1) and Alpha-thalassemia X-linked intellectual disability (ATR-X) syndrome are caused by pathogenic variant in the ATRX gene, a member of the switch/sucrose non-fermentable ...
Yishan Wang +9 more
doaj +1 more source

Cohort profile: a community‐based prospective cohort study of Alzheimer's disease and related dementias in the Democratic Republic of Congo

Alzheimer's &Dementia: Behavior &Socioeconomics of Aging, Volume 2, Issue 2, June 2026.
Abstract INTRODUCTION The Étude du Vieillissement Cognitif et de Démence en République Démocratique du Congo (EVCD‐RDC) launched in 2024 to investigate socio‐environmental and biological determinants of dementia in Kinshasa. METHODS The study recruited 1000 adults aged ≥65 years across four diagnostic groups – cognitively unimpaired (CU), mild ...
Jean Ikanga +24 more
wiley +1 more source

A Case of Malignant Brenner Tumor With High FDG Uptake

Clinical Case Reports, Volume 14, Issue 6, June 2026.
ABSTRACT Malignant Brenner Tumor (MBT) is a rare malignant neoplasm originating from the ovarian surface epithelium. This type of tumor typically lacks specific clinical manifestations and dedicated tumor markers. In our case, we present a complete set of clinical information, diagnosis and treatment protocols, and follow‐up results of one case of MBT.
Jie Li +3 more
wiley +1 more source

Maxillofacial Cemento‐Ossifying Fibroma: A Rare Case Report

Clinical Case Reports, Volume 14, Issue 6, June 2026.
ABSTRACT Cemento‐ossifying fibroma is a relatively rare lesion affecting the jaws, especially the anterior mandible. The most common clinical presentation is swelling. Diagnosis based on clinical observation only is challenging. Radiological images and histological findings can be misleading due to similitudes with other osteo‐fibrous lesions.
Alix N. Kamina +5 more
wiley +1 more source

hypospadias
case report