Results 131 to 140 of about 13,757 (279)

Guideline of guidelines: a critical appraisal of the evidence for PSA retesting intervals

open access: yesBJU International, Volume 136, Issue 3, Page 372-384, September 2025.
Objectives To summarise the recommendations for prostate‐specific antigen (PSA) retesting intervals and to evaluate the evidence cited by each guideline by conducting a systematic review of clinical practice guidelines. Methods We searched PubMed and the Turning Research into Practice (TRIP) database for guidelines written in English and developed or ...
Kiana K. Collins   +4 more
wiley   +1 more source

Adverse prognosis gene expression patterns in metastatic castration‐resistant prostate cancer

open access: yesMolecular Oncology, Volume 19, Issue 8, Page 2348-2365, August 2025.
We aggregated a cohort of 1012 mCRPC tissue samples from 769 patients and investigated the association of gene expression‐based pathways with clinical outcomes. Loss of AR signaling, high proliferation, and a glycolytic phenotype were independently prognostic for poor outcomes, and an adverse transcriptional feature score incorporating these pathways ...
Marina N. Sharifi   +26 more
wiley   +1 more source

Systematic Characterization of Splicing Dysregulation in Pan Solid Tumor Transcriptome

open access: yesAdvanced Science
Splicing dysregulation arising from spliceosomal mutations contributes to disease progression and treatment resistance, mostly in hematologic malignancy. Whereas spliceosomal mutations are less common in solid tumors, splicing disorders are pervasive and
Jingru Sui   +7 more
doaj   +1 more source

Thermal proteome profiling and proteome analysis using high‐definition mass spectrometry demonstrate modulation of cholesterol biosynthesis by next‐generation galeterone analog VNPP433‐3β in castration‐resistant prostate cancer

open access: yesMolecular Oncology, Volume 19, Issue 8, Page 2292-2309, August 2025.
Elevated level of cholesterol is positively correlated to prostate cancer development and disease severity. Cholesterol‐lowering drugs, such as statins, are demonstrated to inhibit prostate cancer. VNPP433‐3β interrupts multiple signaling and metabolic pathways, including cholesterol biosynthesis, AR‐mediated transcription of several oncogenes, mRNA 5′
Retheesh S. Thankan   +10 more
wiley   +1 more source

Impact of magnetic resonance imaging visibility of prostate cancer on partial gland ablation

open access: yesBJUI Compass, Volume 6, Issue 8, August 2025.
Abstract Objectives To evaluate the outcomes of partial gland ablation (PGA) according to prostate cancer (PCa) visibility on magnetic resonance imaging (MRI). Subjects and Methods Consecutive patients with localized PCa diagnosed by MRI‐informed prostate biopsy (PBx), who underwent hemi‐gland Cryoablation (CRYO) or hemi‐gland High‐Intensity Focused ...
Masatomo Kaneko   +11 more
wiley   +1 more source

Identification and Evaluation of the Urinary Microbiota Associated With Bladder Cancer

open access: yesCancer Innovation, Volume 4, Issue 4, August 2025.
Urinary microbiota in Chinese bladder cancer patients reveals distinct profiles between non‐muscle‐invasive and muscle‐invasive diseases, with potential biomarkers like Peptoniphilus spp. in high‐risk MIBC, suggesting a role in cancer progression. Dysbiosis may serve as a stratification marker for bladder cancer risk. ABSTRACT Background Bladder cancer
Nannan Li   +11 more
wiley   +1 more source

Impact of Hypertension on Cancer Stage at Diagnosis Among French Women: The E3N Prospective Cohort

open access: yesCancer Medicine, Volume 14, Issue 15, August 2025.
Time from hypertension onset and anti‐hypertensive drugs were important determinants in the cancer stage at diagnosis in the French E3N cohort. Treated hypertension increased the odds of metastatic thyroid cancer diagnosis, whereas it lowered those odds for lung cancer.
Aviane Auguste   +6 more
wiley   +1 more source

Disability-adjusted life-years (DALYs) for 315 diseases and injuries and healthy life expectancy (HALE) in Iran and its neighboring countries, 1990–2015 [PDF]

open access: yes, 2017
BACKGROUND: Summary measures of health are essential in making estimates of health status that are comparable across time and place. They can be used for assessing the performance of health systems, informing effective policy making, and monitoring the ...
Afshin, A. (Ashkan)   +37 more
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