Results 11 to 20 of about 28,484 (289)

Identification of disulfidptosis related subtypes, characterization of tumor microenvironment infiltration, and development of DRG prognostic prediction model in RCC, in which MSH3 is a key gene during disulfidptosis

open access: yesFrontiers in Immunology, 2023
Disulfidptosis is a newly discovered mode of cell death induced by disulfide stress. However, the prognostic value of disulfidptosis-related genes (DRGs) in renal cell carcinoma (RCC) remains to be further elucidated.
Kai Xu   +16 more
doaj   +1 more source

DOT1L Epigenetically Regulates Autophagy and Mitochondria Fusion in Cell Lines of Renal Cancer

open access: yesTechnology in Cancer Research & Treatment, 2023
Objectives DOT1L, a histone methylase, is overexpression in renal cell cancer. However, the role and detailed molecular mechanism of DOT1L involved in renal cancer development remain unknown.
Yanguang Hou MD   +5 more
doaj   +1 more source

Reformation of the chondroitin sulfate glycocalyx enables progression of AR-independent prostate cancer

open access: yesNature Communications, 2022
Chondroitin sulfate (CS) is one of the most abundant glycosaminoglycans in prostate cancers. Here the authors show that inhibition of the androgen receptor pathway leads to the upregulation of CS, which promotes prostate cancer growth and metastasis.
Nader Al-Nakouzi   +25 more
doaj   +1 more source

Publication of original research in urologic journals--a neglected orphan? [PDF]

open access: yesPLoS ONE, 2012
The pathophysiologic mechanisms behind urologic disease are increasingly being elucidated. The object of this investigation was to evaluate the publication policies of urologic journals during a period of progressively better understanding and management
Jens Mani   +6 more
doaj   +1 more source

Internalization and trafficking of CSPG-bound recombinant VAR2CSA lectins in cancer cells

open access: yesScientific Reports, 2022
Proteoglycans are proteins that are modified with glycosaminoglycan chains. Chondroitin sulfate proteoglycans (CSPGs) are currently being exploited as targets for drug-delivery in various cancer indications, however basic knowledge on how CSPGs are ...
Chris Kedong Wang   +16 more
doaj   +1 more source

Trends in urological stone disease [PDF]

open access: yesBJU International, 2011
Study Type – Therapy (case series)Level of Evidence 4What's known on the subject? and What does the study add? Urolithiasis is a major clinical and economic burden for health care systems. International epidemiological data suggest that the incidence and prevalence of stone disease is increasing. This study demonstrates that the number of diagnoses and
Turney, B   +3 more
openaire   +4 more sources

Urologic emergencies in a low-resource setting: A 10-year review from South-Western Nigeria

open access: yesNigerian Journal of Medicine, 2020
Background: Emergency presentations are quite an important aspect of the urologic practice, and prompt attention is necessary to relieve symptoms, limit morbidity, and prevent mortality.
A A Salako   +7 more
doaj   +1 more source

Pharmacotherapeutic approach toward urological medications and vaccination during COVID-19: a narrative review

open access: yesTherapeutic Advances in Urology, 2021
One year after the prevalence of the novel coronavirus pandemic, some aspects of the physiopathology, treatment and progression of coronavirus 2019 disease (COVID-19) have remained unknown.
Mojtaba Shafiekhani   +6 more
doaj   +1 more source

Urobiome: An outlook on the metagenome of urological diseases [PDF]

open access: yesInvestigative and Clinical Urology, 2021
The urinary tract likely plays a role in the development of various urinary diseases due to the recently recognized notion that urine is not sterile. In this mini review, we summarize the current literature regarding the urinary microbiome and mycobiome and its relationship to various urinary diseases.
Rachel Shoemaker, Jayoung Kim
openaire   +3 more sources

Clinical implications of underactive bladder [PDF]

open access: yesInvestigative and Clinical Urology, 2017
Underactive bladder (UAB) is a common urologic condition but a complex disease that causes troublesome lower urinary tract symptoms. Currently, management of UAB remains unsatisfactory. Also, many urological diseases can be combined with UAB.
Kwang Jin Ko, Chung Un Lee, Kyu-Sung Lee
doaj   +1 more source

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