Results 201 to 210 of about 379,515 (350)

Epigenomics‐guided precision oncology: Chromatin variants in prostate tumor evolution

International Journal of Cancer, Volume 158, Issue 2, Page 314-332, 15 January 2026.
Abstract Prostate cancer is a common malignancy that in 5%–30% leads to treatment‐resistant and highly aggressive disease. Metastasis‐potential and treatment‐resistance is thought to rely on increased plasticity of the cancer cells—a mechanism whereby cancer cells alter their identity to adapt to changing environments or therapeutic pressures to create
Kira Furlano, Tina Keshavarzian, Nadine Biernath, Annika Fendler, Maria de Santis, Joachim Weischenfeldt, Mathieu Lupien   +6 more
wiley   +1 more source

From infection to tumor: genetic evidence of viral antibody immune response' role in urologic cancer development. [PDF]

Discov Oncol
Wang C, Zhang Q, Li Q, Wang Y, Chen X.
europepmc   +1 more source

tRNA‐Derived Fragment tRF‐22 Promotes Immunosuppression by Inhibiting HnRNPAB Ubiquitination in Esophageal Squamous Cell Carcinoma

Advanced Science, Volume 13, Issue 1, 5 January 2026.
tRF‐22 fosters an immunosuppressive and pro‐oncogenic tumor microenvironment in ESCC by stabilizing hnRNPAB against TRIM25‐mediated ubiquitination and enhancing TGFβ2 expression, which increases PMN‐MDSCs infiltration and suppresses CD8+ T cells. Targeting tRF‐22 or blocking TGFβ signalling improves anti‐PD1 response, offering a promising therapeutic ...
Ling Pan, Xin Qin, Li Gong, Haining Liu, Bo Cheng, Jing Wang, Yajie Hu, Lingxing Zeng, Yiping Wang, Qingxu Song, Yufeng Cheng   +10 more
wiley   +1 more source

A urinary DNA methylation assay using two genes enables noninvasive detection and prognostic prediction in urothelial carcinoma. [PDF]

Sci Rep
Wang D, Ai L, Tan H, Yan Y, Ye H, He M, Huang CH, Chen P, Liang Y, Wang R.   +9 more
europepmc   +1 more source

SV2B Promotes the Progression of TFE3‐Rearranged Renal Cell Carcinoma by Interacting with HERC2 to Impede the Degradation of NF‐κB Subunits

Advanced Science, Volume 13, Issue 1, 5 January 2026.
TFE3‐rearranged renal cell carcinoma (TFE3‐RCC) lacks clearly defined diagnostic and therapeutic targets. SV2B, a TFE3 target gene, promotes TFE3‐RCC progression by activating the NF‐κB pathway. Targeted inhibition with padsevonil or Withaferin A effectively suppresses tumor progression.
Huayi Feng, Zhuang Xiong, Shaoqing Yu, Junxiao Liu, Shouqing Cao, Kan Liu, Xing Huang, Lequan Wen, Baojun Wang, Qingbo Huang, Tiejun Pan, Xu Zhang, Xin Ma, Xiubin Li   +13 more
wiley   +1 more source

Establishing Standardized Uptake Value Threshold for Urologic Malignancies With New Analytic Software Based on Extended Single-Photon Emission Computed Tomography-Processed Bone Scintigraphy Images. [PDF]

Cureus
Watanabe S, Motoyama D, Tamura K, Goshima S, Inamoto T.   +4 more
europepmc   +1 more source

ZDHHC2‐Dependent Palmitoylation Dictates Ferroptosis and Castration Sensitivity in Prostate Cancer via Controlling ACSL4 Degradation and Lipid Peroxidation

Advanced Science, Volume 13, Issue 1, 5 January 2026.
Our study reveals a novel mechanism by which palmitoylation regulates ferroptosis and enzalutamide resistance in prostate cancer. Under enzalutamide resistance, the FOXA1/CXXC5/TET2 complex induces aberrant upregulation of ZDHHC2, which subsequently suppresses ferroptosis by mediating S‐palmitoylation of USP19 and degradation of ACSL4 protein in CRPC ...
Shuai Shao, Wei Li, Yulong Hong, Ruijiang Zeng, Liang Zhu, Lu Yi, Yuan Li, Yinhuai Wang, Haojie Huang, Xuewen Jiang, Xin Jin   +10 more
wiley   +1 more source

Translational milestones in urologic pathology: integrating molecular diagnostics across cancer types. [PDF]

J Pathol Clin Res
Matoso A, Acosta AM.
europepmc   +1 more source

The decline of radical nephrectomy: Contemporary trends in the treatment of T1 renal cell carcinoma

BJUI Compass, Volume 7, Issue 1, January 2026.
Abstract Introduction The diagnosis of small renal masses is becoming increasingly common. Management recommendations are shifting from radical nephrectomy (RN) toward nephron‐sparing options such as partial nephrectomy (PN), thermal ablation (TA), and active surveillance (AS). This study aims to present current treatment trends in the USA for treating
Zorawar Singh, Dylan Brown, Justin James, Atieh D. Ashkezari, Manish A. Vira, Arun Rai   +5 more
wiley   +1 more source

Beyond tumour suppression: cGAS-STING pathway in urologic malignancies: Context-dependent duality and therapeutic implications. [PDF]

Clin Transl Med
Wei Q, Zhao K, Wu Y, Wu W, Hao N.
europepmc   +1 more source