Deconvoluting heme biosynthesis to target blood-stage malaria parasites [PDF]
, 2015 Heme metabolism is central to blood-stage infection by the malaria parasite Plasmodium falciparum. Parasites retain a heme biosynthesis pathway but do not require its activity during infection of heme-rich erythrocytes, where they can scavenge host heme ...
Crowley, Jan R +3 more
core +2 more sources
Uroporphyrinogen Decarboxylase Is a Radiosensitizing Target for Head and Neck Cancer
Science Translational Medicine, 2011 Uroporphyrinogen decarboxylase inhibition sensitizes head and neck cancer to both radiotherapy and chemotherapy. A Lightning UROD for Head and Neck Cancer They say lightning never strikes the same place twice—unless, of course, that place is a lightning
Emma Ito +19 more
semanticscholar +1 more source
Decarboxylation of porphyrinogens by rat liver uroporphyrinogen decarboxylase [PDF]
Biochemical Journal, 1979 The decarboxylations of uroporphyrinogens I and III and of heptacarboxylic, hexacarboxylic and pentacarboxylic porphyrinogens III by rat liver uroporphyrinogen decarboxylase were compared, and the results suggest that the removal of the first carboxy group from uroporphyrinogen III is a more rapid step than that from isomer I or the other substrates ...
A G, Smith, J E, Francis
openaire +2 more sources
Transcriptome and metabolome reprogramming in tomato plants by Trichoderma harzianum strain T22 primes and enhances defence responses against aphids [PDF]
, 2019 Beneficial fungi in the genus Trichoderma are among the most widespread biocontrol agents of plant pathogens. Their role in triggering plant defences against pathogens has been intensely investigated, while, in contrast, very limited information is ...
Coppola, Mariangela. +8 more
core +1 more source
Patterns in evolutionary origins of heme, chlorophyll a and isopentenyl diphosphate biosynthetic pathways suggest non-photosynthetic periods prior to plastid replacements in dinoflagellates [PDF]
, 2018 BackgroundThe ancestral dinoflagellate most likely established a peridinin-containing plastid, which have been inherited in the extant photosynthetic descendants.
Inagaki Yuji +2 more
core +2 more sources
A case of porphyria cutanea tarda in the setting of hepatitis C infection and tobacco usage [PDF]
, 2019 Porphyria cutanea tarda (PCT) is the most common type of porphyria, presenting in middle-aged patients with a photodistributed vesiculobullous eruption, milia, and scars.
Brinster, NK +4 more
core
Spot urine porphyrins/creatinine ratio profile of healthy Brazilian individuals adjusted for personal habits [PDF]
, 2009 Changes in urinary porphyrin excretion may be the result of hereditary causes and/or from environmental or occupational exposure. The objective of this study was to measure the amount of some porphyrins in spot urine samples obtained from volunteers ...
ALVES, A.N.L. +3 more
core +2 more sources
A comparative genomics perspective on the genetic content of the alkaliphilic haloarchaeon Natrialba magadii ATCC 43099T [PDF]
, 2012 BACKGROUND: Natrialba magadii is an aerobic chemoorganotrophic member of the Euryarchaeota and is a dual extremophile requiring alkaline conditions and hypersalinity for optimal growth. The genome sequence of Nab.
Diego E Sastre +15 more
core +2 more sources
Sporadic porphyria cutanea tarda due to haemochromatosis [PDF]
, 2006 Haemochromatosis is a hereditary iron-overload syndrome caused by increased intestinal iron absorption and characterised by accumulation of potentially toxic iron in the tissues.
Dees, A., Geus, H.R.H. (Hilde) de
core
Metabolic and molecular events occurring during chromoplast biogenesis [PDF]
, 2011 Chromoplasts are nonphotosynthetic plastids that accumulate carotenoids. They derive from other plastid forms, mostly chloroplasts. The biochemical events responsible for the interconversion of one plastid form into another are poorly documented. However,
Barsan, Cristina +8 more
core +2 more sources