Results 41 to 50 of about 3,350,573 (207)

Semantic data mining and linked data for a recommender system in the AEC industry [PDF]

, 2019
Even though it can provide design teams with valuable performance insights and enhance decision-making, monitored building data is rarely reused in an effective feedback loop from operation to design. Data mining allows users to obtain such insights from
Jensen, Rasmus Lund, Pauwels, Pieter, Petrova, Ekaterina, Svidt, Kjeld   +3 more
core   +2 more sources

4D BIM Application in AEC Industry: Impact on Integrated Project Delivery

, 2015
As project delivery approaches that are supported by Building Information Modelling (BIM) are continuously acknowledged throughout the Architecture, Engineering and Construction (AEC) industry, an innovative modelling approach called 4D BIM is starting ...
U. A. Umar, N. Shafiq, A. Malakahmad, M. Nuruddin, M. Khamidi   +4 more
semanticscholar   +1 more source

DualPG‐DTA: A Large Language Model‐Powered Graph Neural Network Framework for Enhanced Drug‐Target Affinity Prediction and Discovery of Novel CDK9 Inhibitors Exhibiting in Vivo Anti‐Leukemia Activity

Advanced Science, EarlyView.
This study introduces DualPG‐DTA, a framework integrating two pre‐trained models to generate molecular and protein representations. It constructs dual graphs processed by specialized neural networks with dynamic attention for feature fusion, achieving superior benchmark performance.
Yihao Chen, Jindi Huang, Cong Liu, Shipeng Zhang, Xinze Li, Zhang Zhang, Tie‐Gen Chen, Ling Wang   +7 more
wiley   +1 more source

Initial Distance‐Dependent Mean Force Drives Synaptic Vesicle Motion Toward Fusion Sites in Stimulated Hippocampal Neurons

Advanced Science, EarlyView.
Synaptic vesicle (SV) motion and exocytosis dynamics in the presynaptic terminals of live neurons are intimately linked to synaptic transmission during neuronal activity. In this work, it is revealed that, during electrical stimulation, SVs located farther from their fusion sites exhibit greater straightness and experience larger mean forces directed ...
Gyunam Park, Ji‐Hyun Kim, Hunki Lee, Chungwon Park, Sidong Chen, Luke Bates, Jaeyoung Sung, Hyokeun Park   +7 more
wiley   +1 more source

Throughflow centrality is a global indicator of the functional importance of species in ecosystems

, 2012
To better understand and manage complex systems like ecosystems it is critical to know the relative contribution of system components to system functioning. Ecologists and social scientists have described many ways that individuals can be important; This
Abarca-Arenas, Allen, Allesina, Allesina, Allesina, Allesina, Almunia, Bailey, Bailey, Baird, Baird, Baird, Baird, Baird, Baird, Barabási, Baranyi, Bauer, Bodin, Bodini, Bonacich, Bonacich, Borgatti, Borgatti, Borgatti, Borrett, Borrett, Borrett, Borrett, Borrett, Burkhard, Cale, Caswell, Chen, Christian, Dale, Dayton, De Groot, Ellison, Estrada, Estrada, Fann, Fath, Fath, Fath, Fath, Fath, Fath, Fawcett, Finn, Finn, Freeman, Freeman, Friedkin, Gardner, Gondkar, Guimarães, Gunderson, Hahn, Hannon, Heymans, Heymans, Hines, Hooper, Hubbell, Ibarra, Jones, Jordán, Jordán, Jordán, Jørgensen, Jørgensen, Jørgensen, Jørgensen, Kennedy, Koschützki, Krause, Kritz, Lawton, Leontief, Leontief, Lindeman, Link, Loreau, Lotka, Martín González, Miehls, Miehls, Mills, Monaco, Müller, Müller, Newman, Odum, Odum, Odum, Paine, Patten, Patten, Pimm, Pinnegar, Power, Ray, Reed, Rittel, Ruhnau, Saavedra, Salas, Sandberg, Sazima, Scharler, Schneider, Schramski, Scotti, Stuart R. Borrett, Suh, Szyrmer, Ulanowicz, Ulanowicz, Ulanowicz, Ulanowicz, Valente, Walker, Walsh, Wasserman, Whipple, Whittaker, Wilkinson, Zhang, Zhang   +129 more
core   +1 more source

Advanced Human Immune Cell‐Organoid Co‐Cultures for Functional Testing of Cancer Nanovaccines

Advanced Science, EarlyView.
Pancreatic ductal adenocarcinoma remains difficult to treat. We establish an organoid–immune co‐culture using patient‐derived organoids and matched T‐cells to assess cancer vaccines. A mesothelin‐targeted nanovaccine activates antigen‐specific T‐cells, increases IFN‐γ, and targets MSLN+ organoids.
Nathalia Ferreira, David Agorku, Andre Rosa, Julia Roosz, Lena Christ, Nicole Anderle, Ajinkya Kulkarni, Abir Hussein, Sana S. Sayedipour, Omar F. Luna, Tobias Legler, Philipp Ströbel, Fernando Albericio, Luis Cruz, Phillipp Beckhove, Peter Loskill, Frauke Alves, M. Andrea Markus, Fernanda Ramos‐Gomes   +18 more
wiley   +1 more source

Eosinophilic Gastroenteritis Presenting as Intestinal Obstruction - A Case Series. [PDF]

, 2011
Eosinophilic Gastroenteritis is a rare disease characterized by infiltration of the gastrointestinal tract by an increased number of eosinophils as compared to the normal.
Amitha, K, Kumar, AD, Shariff, SA
core   +1 more source

OTUD6A in Airway Epithelial Cells Exacerbates Allergic Asthma by Promoting Airway Inflammation and Airway Remodeling Through Deubiquitination of hResistin/mRELMα

Advanced Science, EarlyView.
This study elucidates a novel mechanistic role of the deubiquitinase OTUD6A in asthma pathogenesis, uncovering its regulatory function in airway inflammation and airway remodeling through the stabilization of hResistin/mRELMα. This study offers a novel regulatory axis (OTUD6A‐hResistin/mRELMα) in asthma pathogenesis and OTUD6A inhibition as a potential
Weiting Pan, Xinru Xi, Wei Dai, Tingfang Xiao, Yeqing Chen, Xuanyu Chen, Xiangting Ge, Chengguang Zhao, Hui Zhang, Yali Zhang, Weixi Zhang   +10 more
wiley   +1 more source

Improved intensifying screen reduces X-ray exposure [PDF]

, 1972
X-ray intensifying screen may make possible radiographic procedures where detection speed and X-ray tube power have been the limiting factors.
Buchanan, R. A.
core   +1 more source

Non‐Targeting shRNA‐Encoded Plasmid DNA Enhances Protective Immunity Through RIDD‐RIG‐I Signaling Pathway in the Zika Virus Animal Model

Advanced Science, EarlyView.
We present a novel DNA vaccine platform featuring intrinsic, non‐targeting dsRNA that significantly enhances immune responses by activating the regulated IRE1‐dependent decay‐RIG‐I signaling pathway. This research elucidates a previously uncharacterized mechanism for dsRNA‐mediated innate immune activation.
Min‐Syuan Huang, Hung‐Chun Liao, Po Peng, Wan‐Ling Wu, Kit Man Chai, Mei‐Yu Chen, Guann‐Yi Yu, Tsung‐Hsien Chuang, Hsin‐Wei Chen, Chuang‐Rung Chang, Shih‐Jen Liu   +10 more
wiley   +1 more source