Results 181 to 190 of about 7,082,252 (307)

Retraction: Machine Learning-Based Data Extraction Tools in Healthcare: A Systematic Review. [PDF]

Cureus
Khalpey Z, Rorvig M, Khalpey ZI, Kumar U, Khaliel FH, King N.   +5 more
europepmc   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

DRIFteRS: A dataset of drift invertebrate densities in streams and rivers across western North America, 1997-2024. [PDF]

Ecology
Toskey EK, Matsuoka T, Kiffney PM, Naman SM, Liermann MC, Bailey J, Beauchamp DA, Bellmore JR, Binckley CA, Blumenshine S, Caldwell TJ, Carey MP, Claeson S, Clawson C, Cox R, Cromwell KJ, Danehy RJ, Dodrill MJ, Duda JJ, Fellman JB, Grimm AZ, Hallbert TB, Jordan CE, Keeley ER, Kennedy BP, Kennedy TA, Kohler AE, Lowery ED, Macneale K, Martens KD, Morley SA, Muehlbauer JD, Neuswanger JB, O'Dowd A, Pneh S, Power M, Rhoades SJ, Rosenfeld J, Rossi G, Sanderson BL, Shelby KK, Starkey-Owens T, Thompson JN, Volk C, Williamshen JS, Wisseman RW.   +45 more
europepmc   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Impact of the hidden curriculum and unprofessionalism on medical student specialty choice. [PDF]

Acad Pathol
George MR, White KL, Puligandla B, Gosnell HL, Lofgreen A, Johnson K, Barak S, Berg MP, Chahar S, Childs JM, Knollmann-Ritschel BEC, Karp JK, McCloskey CB, Bryant BH.   +13 more
europepmc   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Theory of Mind, Emotional Intelligence and Psychopathology.

Revista E-Psi, 2012
MÓNICA JOSÉ ABREU SO USA
doaj  

N-of-1 investigational study of a novel antisense oligonucleotide drug in CHCHD10-related ALS shows early signs of efficacy. [PDF]

Med
Cousin MA, Dagli AI, Mignon L, Shah JS, Prudencio M, Gendron TF, Jain A, Udine E, van Blitterswijk M, Middlebrooks EH, Donahue MH, Dagher JE, Watzlawik JO, Springer W, Parekh T, McEachin ZT, Petrucelli L, Oskarsson B.   +17 more
europepmc   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Author Correction: Cancer-associated fibroblast-derived acetate promotes pancreatic cancer development by altering polyamine metabolism via the ACSS2-SP1-SAT1 axis. [PDF]

Nat Cell Biol
Murthy D, Attri KS, Shukla SK, Thakur R, Chaika NV, He C, Wang D, Jha K, Dasgupta A, King RJ, Mulder SE, Souchek J, Gebregiworgis T, Rai V, Patel R, Hu T, Rana S, Kollala SS, Pacheco C, Grandgenett PM, Yu F, Kumar V, Lazenby AJ, Black AR, Ulahannan S, Jain A, Edil BH, Klinkebiel DL, Powers R, Natarajan A, Hollingsworth MA, Mehla K, Ly Q, Chaudhary S, Hwang RF, Wellen KE, Singh PK.   +36 more
europepmc   +1 more source