Results 91 to 100 of about 51,027,052 (360)

COMPUTER-AIDED PROTEIN DIRECTED EVOLUTION: A REVIEW OF WEB SERVERS, DATABASES AND OTHER COMPUTATIONAL TOOLS FOR PROTEIN ENGINEERING

Computational and Structural Biotechnology Journal, 2012
The combination of computational and directed evolution methods has proven a winning strategy for protein engineering. We refer to this approach as computer-aided protein directed evolution (CAPDE) and the review summarizes the recent developments in ...
Rajni Verma, Ulrich Schwaneberg, Danilo Roccatano   +2 more
doaj   +3 more sources

Support vector machines in structural engineering: a review

Journal of Civil Engineering and Management, 2015
Recent development in data processing systems had directed study and research of engineering towards the creation of intelligent systems to evolve models for a wide range of engineering problems.
Abdulkadir Çevik, Ahmet Emin Kurtoğlu, Mahmut Bilgehan, Mehmet Eren Gülşan, Hasan M. Albegmprli   +4 more
doaj   +1 more source

Surfaceome: a new era in the discovery of immune evasion mechanisms of circulating tumor cells

Molecular Oncology, EarlyView.
In the era of immunotherapies, many patients either do not respond or eventually develop resistance. We propose to pave the way for proteomic analysis of surface‐expressed proteins called surfaceome, of circulating tumor cells. This approach seeks to identify immune evasion mechanisms and discover potential therapeutic targets. Circulating tumor cells (
Doryan Masmoudi, Jérome Vialaret, Christophe Hirtz, Catherine Alix‐Panabières   +3 more
wiley   +1 more source

Usability of AutoProof: a case study of software verification [PDF]

arXiv, 2016
Many verification tools come out of academic projects, whose natural constraints do not typically lead to a strong focus on usability. For widespread use, however, usability is essential. Using a well-known benchmark, the Tokeneer problem, we evaluate the usability of a recent and promising verification tool: AutoProof. The results show the efficacy of
arxiv  

Circulating tumor cells in metastatic breast cancer patients treated with immune checkpoint inhibitors – a biomarker analysis of the ALICE and ICON trials

Molecular Oncology, EarlyView.
In this explorative biomarker analysis, we assessed serial sampling of circulating tumor cells (CTCs) with CellSearch in two randomized trials testing immune checkpoint inhibitors (ICIs) in metastatic breast cancer. Our data demonstrate a prognostic potential of CTCs, most apparent 4 weeks into ICI therapy.
Nikolai Kragøe Andresen, Andreas Hagen Røssevold, Elin Borgen, Cecilie Bendigtsen Schirmer, Bjørnar Gilje, Øystein Garred, Jon Lømo, Marius Stensland, Oddmund Nordgård, Ragnhild Sørum Falk, Randi R. Mathiesen, Hege G. Russnes, Jon Amund Kyte, Bjørn Naume   +13 more
wiley   +1 more source

Circulating tumor cells: advancing personalized therapy in small cell lung cancer patients

Molecular Oncology, EarlyView.
Small cell lung cancer (SCLC) is an aggressive form of lung cancer that spreads rapidly to secondary sites such as the brain and liver. Cancer cells circulating in the blood, “circulating tumor cells” (CTCs), have demonstrated prognostic value in SCLC, and evaluating biomarkers on CTCs could guide treatment decisions such as for PARP inhibitors ...
Prajwol Shrestha, Steven Kao, Veronica K. Cheung, Wendy A. Cooper, Nico van Zandwijk, John E. J. Rasko, Dannel Yeo   +6 more
wiley   +1 more source

Usability Engineering of Games: A Comparative Analysis of Measuring Excitement Using Sensors, Direct Observations and Self-Reported Data [PDF]

arXiv, 2014
Usability engineering and usability testing are concepts that continue to evolve. Interesting research studies and new ideas come up every now and then. This paper tests the hypothesis of using an EDA based physiological measurements as a usability testing tool by considering three measures which are observers opinions, self reported data and EDA based
arxiv  

The water supply of towns and the construction of waterworks. A practical treatise for the use of engineers and students of engineering. [PDF]

, 1894

openalex   +1 more source

A comparative study of circulating tumor cell isolation and enumeration technologies in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells were spiked into donor blood to evaluate the recovery rates of the following circulating tumor cell (CTC) enrichment technologies: CellMag™, EasySep™, RosetteSep™, Parsortix® PR1, and Parsortix® Prototype systems. Each method's advantages and disadvantages are described.
Volga M Saini, Ezgi Oner, Mark P. Ward, Sinead Hurley, Brian David Henderson, Faye Lewis, Stephen P. Finn, Gerard J. Fitzmaurice, John J. O'Leary, Sharon O'Toole, Lorraine O'Driscoll, Kathy Gately   +11 more
wiley   +1 more source

Crowdsourcing: A Framework for Usability Evaluation [PDF]

arXiv
Objective: This research explores using crowdsourcing for software usability evaluation. Background: Usability studies are essential for designing user-friendly software, but traditional methods are often costly and time-consuming. Crowdsourcing offers a quicker, cost-effective alternative for remote usability evaluation, though ensuring quality ...
arxiv