Results 51 to 60 of about 51,027,052 (360)

Ablation of LRP6 in alpha‐smooth muscle actin‐expressing cells abrogates lung inflammation and fibrosis upon bleomycin‐induced lung injury

FEBS Letters, EarlyView.
Low‐density lipoprotein receptor‐related protein 6 (LRP6) is a key receptor for the Wnt antagonist Dickkopf1 (DKK1). DKK1 protein expression is induced in a bleomycin (BLM)‐induced lung injury model. We show that DKK1 induces proinflammatory and profibrotic genes in lung fibroblasts.
Eun‐Ah Sung, Mikhail G. Dozmorov, SuJeong Song, Theingi Aung, Min Hee Park, Patricia J. Sime, Wook‐Jin Chae   +6 more
wiley   +1 more source

How Do Induced Affective States Bias Emotional Contagion to Faces? A Three-Dimensional Model

Frontiers in Psychology, 2020
Affective states can propagate in a group of people and influence their ability to judge others’ affective states. In the present paper, we present a simple mathematical model to describe this process in a three-dimensional affective space.
Andrés Pinilla, Ricardo M. Tamayo, Jorge Neira   +2 more
doaj   +1 more source

Insertion of the FeB cofactor in cNORs lacking metal inserting chaperones

FEBS Letters, EarlyView.
Nitric oxide reductase is an enzyme found in the bacterial denitrification pathway. The NOR active site contains a non‐heme iron, often, but not always inserted with the assistance of chaperones. Here, we study the insertion of FeB in the subfamily of cNORs lacking chaperones and found a putative channel, conserved in the family, perhaps enabling the ...
Sofia Appelgren, Pia Ädelroth
wiley   +1 more source

Evaluation of SPARK C++ Usability: Modular Programming for Mechanical and Civil Engineering Students

Journal of Computing Research and Innovation
Technological innovations have transformed education, offering learning opportunities outside traditional classrooms through online resources. However, self-learning programming remains challenging for beginners.
Azrina Suhaimi, Mohamad Faizal Ab Jabal, Harshida Hasmy, Azyan Yusra Kapi @ Kahbi   +3 more
doaj   +1 more source

Academic Search Engines: Constraints, Bugs, and Recommendation [PDF]

arXiv, 2022
Background: Academic search engines (i.e., digital libraries and indexers) play an increasingly important role in systematic reviews however these engines do not seem to effectively support such reviews, e.g., researchers confront usability issues with the engines when conducting their searches.
arxiv  

Taurine promotes glucagon‐like peptide‐1 secretion in enteroendocrine L cells

FEBS Letters, EarlyView.
Taurine, a sulfur‐containing amino acid, is likely taken up by enteroendocrine L cells via the taurine transporter. This process increases the levels of cytosolic ATP. The increase in intracellular Ca2+ concentrations and glucagon‐like peptide‐1 secretion through membrane depolarization is caused by the closure of ATP‐sensitive potassium channels ...
Yuri Osuga, Kazuki Harada, Takuya Yamauchi, Tetsuya Kitaguchi, Masami Yokota Hirai, Mitsuharu Matsumoto, Takashi Tsuboi   +6 more
wiley   +1 more source

The multiple roles of the NlpC_P60 peptidase family in mycobacteria – an underexplored target for antimicrobial drug discovery

FEBS Letters, EarlyView.
The NlpC_P60 superfamily of peptidases is recognised by its key role in bacterial cell wall homeostasis. Recently, studies have also described the involvement of NlpC_P60‐like enzymes in bacterial competitive mechanisms and pathogenesis across several lineages.
Catharina dos Santos Silva, Marcio Vinicius Bertacine Dias   +1 more
wiley   +1 more source

Understanding Spatial Data Usability

Data Science Journal, 2003
In recent geographical information science literature, a number of researchers have made passing reference to an apparently new characteristic of spatial data known as 'usability'.
Gary J Hunter, Monica Wachowicz, Arnold K Bregt   +2 more
doaj   +1 more source

Integrating Software Engineering and Usability Engineering [PDF]

, 2008
We would like to express our sincere appreciation to all those who have contributed, directly or indirectly, to this work in form of technical or other support. In particular we would like to thank Markus D?chting for his assistance. A special thank to Lennart Gr?tzbach always helping us to find the right words.
Volker Paelke, Karsten Nebe, Dirk Zimmermann   +2 more
openaire   +3 more sources

Unraveling Mycobacterium tuberculosis acid resistance and pH homeostasis mechanisms

FEBS Letters, EarlyView.
Mycobacterium tuberculosis exhibits a remarkable resilience to acid stress. In this Review, we discuss some of the molecular mechanisms and metabolic pathways used by the tubercle bacilli to adapt and resist host‐mediated acid stress. Mycobacterium tuberculosis (Mtb) is a successful pathogen that has developed a variety of strategies to survive and ...
Janïs Laudouze, Stéphane Canaan, Alexandre Gouzy, Pierre Santucci   +3 more
wiley   +1 more source