Results 231 to 240 of about 427,404 (301)

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Nurses' Evaluation of a Service Robot for Inpatient Care: Technology Acceptance Study. [PDF]

JMIR Nurs
Friese C, Klebbe R, Heimann-Steinert A.
europepmc   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Developing a Cross-Device Platform for Robotic Systems in Nursing Care: Mixed Methods Feasibility Study. [PDF]

JMIR Nurs
Müller P, Veit R, Hofstetter S, Jahn P.
europepmc   +1 more source

Usability Validation of an Integrated Hemodynamic and Pulmonary Monitoring System Using Eye-Tracking Analysis. [PDF]

J Clin Med
Jeong H, Choi H, Kim H, Jang W.
europepmc   +1 more source

FunduScope: a human-centered, machine learning-based interactive tool for training junior ophthalmologists in diabetic retinopathy detection. [PDF]

Front Big Data
Bittner SJ, Barz M, Sonntag D.
europepmc   +1 more source

Evaluation of Wellby, a Cocreated Mobile App and Wearable to Support Stress Management and Overall Well-Being: Mixed Methods Acceptability and Usability Study.

JMIR Hum Factors
Laiti J, Javadpour S, Mullen J, Conway C, Byrne E, Dunne P.   +5 more
europepmc   +1 more source

A Methodology for Evaluating User Experience in Human-Centered Extended Reality Applications. [PDF]

Biomimetics (Basel)
Quiñones D, Rojas LF, Olavarría R, Cubillos C, Muñoz-La Rivera F.   +4 more
europepmc   +1 more source

A municipality implemented behavioural intervention to improve quality of life among older adults: protocol for a mixed-methods pilot case study. [PDF]

Pilot Feasibility Stud
Gerhardsson KM, Brogårdh C, Tornberg ÅB, Hellblom E, Schmidt SM.   +4 more
europepmc   +1 more source